- What goes in the regulatory clinical pharmacology package for an oncolytic virus?
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Yum SY, Jang K, Castro FAd, Manon A
- KMID: 2552413
- Transl Clin Pharmacol.
- 2023 Sep;31(3):125-130.
- doi: 10.12793/tcp.2023.31.e14
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- Transforming clinical trials: the emerging roles of large language models
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Ghim JL, Ahn S
- KMID: 2552414
- Transl Clin Pharmacol.
- 2023 Sep;31(3):131-138.
- doi: 10.12793/tcp.2023.31.e16
Clinical trials are essential for medical research, but they often face challenges in matching patients to trials and planning. Large language models (LLMs) offer a promising solution, signaling a transformative... -
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- Effects of rifampin coadministration on the pharmacokinetics of digoxin: a real-world data approach
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Oh J, Kim B, Lee S
- KMID: 2552424
- Transl Clin Pharmacol.
- 2023 Sep;31(3):148-153.
- doi: 10.12793/tcp.2023.31.e13
Digoxin, a cardiac glycoside, is commonly prescribed to treat heart failure and atrial fibrillation. Because digoxin acts as a substrate of P-glycoprotein (P-gp), its blood concentration may be reduced by... -
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- Quantification of OATP1B1 endogenous metabolites coproporphyrin I and III in human urine
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Jang Y, Kang J, Hwang S, Chung JY, Cho JY
- KMID: 2552415
- Transl Clin Pharmacol.
- 2023 Sep;31(3):139-147.
- doi: 10.12793/tcp.2023.31.e12
Coproporphyrin (CP)-I and CP-III are the markers of organic anion-transporting polypeptides’ (OATPs) activities, and they are porphyrin metabolites that originate from heme synthesis. Furthermore, CP-I and CP-III, which are OATP1B endogenous... -
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- Response surface analyses of antihypertensive effects of angiotensin receptor blockers and amlodipine or hydrochlorothiazide combination therapy in patients with essential hypertension
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Cho M, Oh E, Ahn B, Yoon M
- KMID: 2552425
- Transl Clin Pharmacol.
- 2023 Sep;31(3):154-166.
- doi: 10.12793/tcp.2023.31.e15
While previous studies have examined the dose-response characteristics of certain antihypertensive drugs alone or in combination, response surface analysis for combination therapies involving angiotensin receptor blockers (ARBs) and either amlodipine... -
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