- Melatonin and melatonergic drugs in sleep disorders
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Kim HK, Yang KI
- KMID: 2538878
- Transl Clin Pharmacol.
- 2022 Dec;30(4):163-171.
- doi: 10.12793/tcp.2022.30.e21
Melatonin is an endogenous chronobiological regulator secreted mainly from the pineal gland, which has been used as a dietary supplement in the treatment of sleep problems, including insomnia, parasomnia, and... -
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- Building and analyzing machine learning-based warfarin dose prediction models using scikit-learn
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Ahn S
- KMID: 2538879
- Transl Clin Pharmacol.
- 2022 Dec;30(4):172-181.
- doi: 10.12793/tcp.2022.30.e22
For personalized drug dosing, prediction models may be utilized to overcome the inter-individual variability. Multiple linear regression has been used as a conventional method to model the relationship between patient... -
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- Common ABCB1 SNP, C3435T could affect systemic exposure of dapagliflozin in healthy subject
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Hwang JG, Jeong SI, Kim YK, Lee Y, Ji SC, Lee S, Park MK
- KMID: 2538883
- Transl Clin Pharmacol.
- 2022 Dec;30(4):212-225.
- doi: 10.12793/tcp.2022.30.e23
P-glycoprotein (P-gp) is a transporter that plays an excretory role in epithelial cells. It is encoded by ABCB1, and single nucleotide polymorphisms (SNPs) in this gene can affect systemic drug... -
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- Factors influencing decision making and antibiotic prescribing patterns for the treatment of carbapenem-resistant Enterobacteriaceae (CRE) among non-infectious physicians in Thailand: a qualitative study
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Soontaros S, Leelakanok N, Mepradis Y, Auamnoy T
- KMID: 2538881
- Transl Clin Pharmacol.
- 2022 Dec;30(4):187-200.
- doi: 10.12793/tcp.2022.30.e18
The treatment of carbapenem-resistant Enterobacteriaceae (CRE) is diverse in each region due to the difference in local resistant patterns of CRE. We aimed to explore how physicians in Thailand decide... -
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- A case of sinus arrest in atrial fibrillation with pulmonary embolism after flecainide ingestion
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Jeong HK, Kim SS, Kim HK, Ki YJ, Park KH, Choi DH
- KMID: 2538880
- Transl Clin Pharmacol.
- 2022 Dec;30(4):182-186.
- doi: 10.12793/tcp.2022.30.e19
A 76-year-old female visited the emergency department with complaining of dizziness and syncope. She had a history of paroxysmal atrial fibrillation (AF) and had been prescribed flecainide 50 mg and... -
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- Predicting the systemic exposure and lung concentration of nafamostat using physiologically-based pharmacokinetic modeling
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Jeong HC, Chae YJ, Shin KH
- KMID: 2538882
- Transl Clin Pharmacol.
- 2022 Dec;30(4):201-211.
- doi: 10.12793/tcp.2022.30.e20
Nafamostat has been actively studied for its neuroprotective activity and effect on various indications, such as coronavirus disease 2019 (COVID-19). Nafamostat has low water solubility at a specific pH and... -
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