- The use of real-world data in drug repurposing
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Park K
- KMID: 2525613
- Transl Clin Pharmacol.
- 2021 Sep;29(3):117-124.
- doi: 10.12793/tcp.2021.29.e18
Drug repurposing, or repositioning, is to identify new uses for existing drugs. Significantly reducing the costs and time-to-market of a medication, drug repurposing has been an alternative tool to accelerate... -
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- Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform
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Kim B, Yoon DY, Lee S, Jang IJ, Yu KS, Cho JY, Oh J
- KMID: 2525616
- Transl Clin Pharmacol.
- 2021 Sep;29(3):135-149.
- doi: 10.12793/tcp.2021.29.e14
Genetic polymorphisms of enzymes and transporters associated with the absorption, distribution, metabolism, and elimination (ADME) of drugs are one of the major factors that contribute to interindividual variations in drug... -
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- Comparison of the pharmacokinetics and pharmacodynamics of YH4808 in healthy subjects for defining an appropriate dosing regimen
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Yoon S, Oh E, Park MS, Jang SB, Byun HM, Park H, Kim H, Kim CO
- KMID: 2525612
- Transl Clin Pharmacol.
- 2021 Sep;29(3):150-159.
- doi: 10.12793/tcp.2021.29.e15
YH4808 is a novel potassium-competitive acid blocker developed for gastric acid-related disorders. Previous studies indicate its potential to improve symptoms of gastric acid-related disorders. The current study was aimed to... -
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- Validation of LC-MS/MS method for determination of rosuvastatin concentration in human blood collected by volumetric absorptive microsampling (VAMS)
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Moon SJ, Lee SE, Kwak YG, Kim MG
- KMID: 2525617
- Transl Clin Pharmacol.
- 2021 Sep;29(3):125-134.
- doi: 10.12793/tcp.2021.29.e13
In light of the shift toward patient-centric clinical trials, a measure of simplifying blood collection process and minimizing the volume of blood samples is on the rise. Volumetric absorptive microsampling... -
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- The possibility of low isomerization of β-lapachone in the human body
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Lee KM, Gwon MR, Lee HW, Seong SJ, Yoon YR
- KMID: 2525615
- Transl Clin Pharmacol.
- 2021 Sep;29(3):160-170.
- doi: 10.12793/tcp.2021.29.e16
β-Lapachone has been reported to have anticancer and various other therapeutic effects, but is limited in clinical applications by its low bioavailability. pH-Dependent isomerization can be suggested as one plausible... -
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- Pharmacokinetic properties and bioequivalence of gefitinib 250 mg in healthy Korean male subjects
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Moon SJ, Kim Y, Jeon JY, Park SJ, Kwak YG, Kim MG
- KMID: 2525614
- Transl Clin Pharmacol.
- 2021 Sep;29(3):171-179.
- doi: 10.12793/tcp.2021.29.e17
Gefitinib is an anti-cancer drug used to treat non-small cell lung cancer. The objective of this study was to compare the pharmacokinetics and evaluate the bioequivalence of 2 orally administered... -
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