- Brief introduction to parametric time to event model
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Lim HS
- KMID: 2525600
- Transl Clin Pharmacol.
- 2021 Mar;29(1):1-5.
- doi: 10.12793/tcp.2021.29.e7
This tutorial explains the basic concept of parametric time to event (TTE) models, focusing on commonly used exponential, Weibull, and log-logistic model. TTE data is commonly used as endpoint for... -
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- Comparative pharmacokinetics between tenofovir disoproxil phosphate and tenofovir disoproxil fumarate in healthy subjects
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Lee S, Kim E, Moon SJ, Jung J, Lee S, Yu KS
- KMID: 2525602
- Transl Clin Pharmacol.
- 2021 Mar;29(1):45-52.
- doi: 10.12793/tcp.2021.29.e4
Tenofovir is the representative treatment for human immunodeficiency virus and hepatitis B virus infection. This study was conducted to assess the pharmacokinetics (PKs) and safety characteristics after a single administration... -
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- Physiologically-based pharmacokinetic model for clozapine in Korean patients with schizophrenia
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Lee J, Kim MG, Jeong HC, Shin KH
- KMID: 2525605
- Transl Clin Pharmacol.
- 2021 Mar;29(1):33-44.
- doi: 10.12793/tcp.2021.29.e3
Clozapine has been used as a treatment of schizophrenia. Despite its large interindividual variability, few reports addressed the physiologically-based pharmacokinetic modeling and simulation (PBPK M&S) of clozapine in patients. This... -
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- A meta-analysis: efficacy and safety of anti-epileptic drugs prescribed in Korea as monotherapy and adjunctive treatment for patients with focal epilepsy
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Jeon J, Oh J, Yu KS
- KMID: 2525604
- Transl Clin Pharmacol.
- 2021 Mar;29(1):6-20.
- doi: 10.12793/tcp.2021.29.e1
Focal epilepsy is the most common type of epilepsy in Korea, and anti-epileptic drugs (AEDs) are the main treatment option for patients. This study aimed to compare the efficacy and... -
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- Pharmacokinetic comparison between a fixed-dose combination of fimasartan/amlodipine/ hydrochlorothiazide 60/10/25 mg and a corresponding loose combination of fimasartan/amlodipine 60/25 mg and hydrochlorothiazide 25 mg in healthy subjects
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Jung J, Lee S, Oh J, Lee S, Jang IJ, Lee D, Yu KS
- KMID: 2525603
- Transl Clin Pharmacol.
- 2021 Mar;29(1):53--64.
- doi: 10.12793/tcp.2021.29.e5
For the treatment of hypertension, fixed-dose combinations (FDCs) of antihypertensive drugs can provide complementary benefits from improved compliance and cost-effectiveness compared with loose combinations of corresponding drugs. A new FDC... -
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- Comparison of pharmacokinetics and safety characteristics between two olopatadine hydrochloride 5 mg tablet formulations in healthy Korean subjects
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Kim JH, Lee M, Kim N, Oh TY, Nam SK, Choi YS, Kwon IS, Jung JG, Hong JH
- KMID: 2525601
- Transl Clin Pharmacol.
- 2021 Mar;29(1):65-72.
- doi: 10.12793/tcp.2021.29.e6
Histamine acts by binding to four histamine receptors (H1 to H4), of which the H1 is known to participate in dilate blood vessels, bronchoconstriction, and pruritus. Olopatadine hydrochloride blocks the... -
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- Cognitive improvement effect of gintonin might be associated with blood-brain barrier permeability enhancement: dynamic contrastenhanced MRI pilot study
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Lee WJ, Shin YW, Chang H, Shin HR, Kim WW, Jung SW, Choi SH, Kim M, Nah SY
- KMID: 2525606
- Transl Clin Pharmacol.
- 2021 Mar;29(1):21-32.
- doi: 10.12793/tcp.2021.29.e2
Along with the multiple neuroprotective effect, recent studies suggest that gintonin might increase the blood brain barrier permeability. We evaluated the effect of gintonin on the vascular permeability changes in... -
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