- The Heterochromatin-1 Phosphorylation Contributes to TPA-Induced AP-1 Expression
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Choi WJ
- KMID: 2170624
- Biomol Ther.
- 2014 Jul;22(4):308-313.
Activator protein-1 (AP-1) is an inducible transcription factor that contributes to the generation of chronic inflammation in response to oxidative and electrophilic stress. Previous studies have demonstrated that the PI3K/Akt1... -
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- Effects of dopamine and haloperidol on morphine-induced CREB and AP-1 DNA binding activities in differentiated SH-SY5Y human neuroblastoma cells
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Kim SK, Kwon GY
- KMID: 2071825
- Korean J Physiol Pharmacol.
- 1998 Dec;2(6):671-676.
In the present study, we first examined whether the changes in the DNA binding activities of the transcription factors, cAMP response element binding protein (CREB) and activator protein-1 (AP-1) mediate the long-term effects... -
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- The Effect of All-Trans-Retinoic Acid and Ursolic Acid on the Ultraviolet A Radiation Induced AP-1 (Fos/Jun) Activity in Cultured Human Dermal Fibroblasts
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Kim HC, Yang JS, Chae YS, Suh KS, Kim ST
- KMID: 2425604
- Korean J Dermatol.
- 1997 Dec;35(6):1136-1142.
BACKGROUND: Recently, UVB irradiation was found to activate AP-1, which is known to be a major enhancer factor of the collagenase gene. However, tbe effect of UVA irradiation on the... -
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- The Effect of an AP-1 decoy on Collagen Synthesis in Wound Healing on Rat Skin: The use of Gene Therapy to Minimise Scarring
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Park SJ, Lee KS
- KMID: 2302636
- Korean J Dermatol.
- 2005 Apr;43(4):435-441.
BACKGROUND: The wound healing process is composed of inflammation, cellular growth, migration, angiogenesis and an extracellular matrix composition. In this process, fibroblasts proliferate but leave scarring due to their excessive... -
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- Cooperative effect of Alternaria and rhinovirus on the activation of nasal polyp epithelial cells
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Shin SH, Ye MK, Jeon BG, Jang YJ
- KMID: 2132060
- J Rhinol.
- 2012 Nov;19(2):112-118.
BACKGROUND AND OBJECTIVES: The nasal epithelium is the first barrier encountered by airborne allergens and is an active participant in airway inflammation. The aim of this study was to determine... -
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- STP-A11, an oncoprotein of Herpesvirus saimiri augments both NF-kappaB and AP-1 transcription activity through TRAF6
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Jeong S, Cho IR, An WG, Jhun BH, Lee BS, Park K, Chung YH
- KMID: 1103681
- Exp Mol Med.
- 2007 Feb;39(1):56-64.
Herpesvirus saimiri (HVS), a member of the gamma-herpesvirus family, encodes an oncoprotein called Saimiri Transforming Protein (STP) which is required for lymphoma induction in non-human primates. However, a detailed mechanism... -
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- Gliotoxin induces the Apoptosis in HL-60 Cells
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Chung HT, Park RK, Choi YK, Lee SR, Kim YH, Cho KH, Jang YW
- KMID: 1557245
- Korean J Immunol.
- 1998 Dec;20(4):397-403.
Many fungi including Penicillium, Aspergillus, Gliocladium, and Thermoascus produce an epipolythiodioxopiperazine class of fungal metabolite, gliotoxin, which contirbutes the pathogenesis of fungal infection as an immunomodulator and cytotoxic agent. This... -
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- The Effect of UVB on the NF-kB and AP-1 Activity in Cultured Human Keratinocytes and Fibroblasts
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Koo BS, Ryoo YW, Lee KS
- KMID: 2303452
- Korean J Dermatol.
- 1997 Jun;35(3):411-417.
BACKGROUND: Ultraviolet B(UVB) light, which can cause severe damage like induction and promotion of cancer, cutaneous inflammation and immunosuppression, represents one of the most important environmental impacts for humans. Keratinocytes... -
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- Growth Regulation of Ovarian Cancer Cells through the Inactivation of AP-1 by Retinoid Derivatives
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Koh YM, Park JS, Namkoong S, Lee SY, Kim SA, Hong KJ, Um SJ
- KMID: 2329189
- J Korean Cancer Assoc.
- 2000 Dec;32(6):1043-1049.
PURPOSE: The growth regulatory effect of retinoid derivatives could be mediated by the transcriptional inactivation of AP-1 oncogenic transcription factor. By using ovarian cancer cell lines we were to investigate... -
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- Effects of Multiple Cyclic Episodes with Short Ischemia and Reperfusion on the Distribution of NF-kappa B, AP-1, Bcl-2, and Bax in Rectus Femoris Muscles of Rats
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Seo YK, Paik DJ, Nam YS, Kweon TH, Kim TS
- KMID: 2283202
- Korean J Phys Anthropol.
- 2005 Mar;18(1):45-55.
The present study was designed to observe the expression patterns of NF-kappa B and AP-1, redox-sensitive transcription factors, and Bcl-2 and Bax, apoptosis repressing and promoting factors, respectively, upon repetitive... -
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- Activation of NF-κB and AP-1 Mediates Hyperproliferation by Inducing β-Catenin and c-Myc in Helicobacter pylori-Infected Gastric Epithelial Cells
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Byun E, Park B, Lim JW, Kim H
- KMID: 2374084
- Yonsei Med J.
- 2016 May;57(3):647-651.
- doi: 10.3349/ymj.2016.57.3.647
PURPOSE: In the gastric mucosa of Helicobacter pylori (H. pylori)-infected patients with gastritis or adenocarcinoma, proliferation of gastric epithelial cells is increased. Hyperproliferation is related to induction of oncogenes, such... -
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- IL-10 Inihibits VEGF Production in the Synovial Fibroblasts of RA Patients via Down-regulation of the ERK and AP-1 Pathways
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Lee SY, Cho ML, Park MK, Oh HJ, Park SH, Kim HY
- KMID: 2334866
- J Korean Rheum Assoc.
- 2009 Sep;16(3):213-222.
OBJECTIVE: Interleukin (IL)-10 has been demonstrated to have anti-inflammatory and anti-tumour activity. Because aberrant angiogenesis is a significant pathogenic component of tumor growth and chronic inflammation, we investigated the effect... -
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- Activation of NF-kappaB and AP-1 in Peripheral Blood Mononuclear Cells Isolated from Patients with Diabetic Nephropathy
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Nam J, Cho MH, Park JS, Lee GT, Kim HJ, Kang ES, Lee YM, Ahn CW, Cha BS, Lee EJ, Lim SK, Kim KR, Ha HJ, Lee HC
- KMID: 1523015
- J Korean Diabetes Assoc.
- 2007 May;31(3):261-273.
- doi: 10.4093/jkda.2007.31.3.261
BACKGROUND: We evaluated the role of oxidative stress in diabetic nephropathy by measuring intracellular reactive oxygen species (ROS) and redox-sensitive transcription factors in isolated peripheral mononuclear cells (PBMC). METHODS: From... -
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- Inhibition of Lipopolysaccharide-stimulated Inflammatory Cytokine Production by LY303511 in Human Macrophagic THP-1 Cells
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Kim SH, Paek YW, Kang IC
- KMID: 2394580
- Int J Oral Biol.
- 2017 Sep;42(3):117-121.
- doi: 10.11620/IJOB.2017.42.3.117
We have previously shown that the specific phosphatidylinositol 3-kinase inhibitor LY294002 (LY29), and its inactive analog LY303511 (LY30), inhibit a monocyte chemoattractant protein-1 (MCP-1) expression in human umbilical vein endothelial... -
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- Role of Activation of NF- B and AP-1 by Oxidative Stress in Atherosclerosis in Diabetic Patients
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Kim CS, Lee GT, Park J, Cho MH, Nam JY, Park JS, Kim DM, Ahn CW, Cha BS, Lim SK, Kim KR, Lee HC
- KMID: 2008154
- J Korean Diabetes Assoc.
- 2004 Aug;28(4):255-264.
BACKGROUND: The aim of this study was to evaluate the possible role of NF- B activation and AP-1 by oxidative stress in atherosclerosis in diabetic patients by measuring the carotid... -
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- Mapping of Human Cytomegalovirus IE1 Responsive Elements in the c-jun Promoter
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Kim DJ, Kim JH, Choi SB, Han TH, Park CG, Hwang ES, Cha CY
- KMID: 1551995
- J Korean Soc Virol.
- 1998 Sep;28(3):267-274.
Human cytomegalovirus (HCMV) has the ability to activate the espremission of many viral and cellular genes. Among various viral proteins, the immediate early proteins (IE1-72kDa, IE2-86kDa) have been known to... -
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- Studies on the Mechanism of Hypoxic Increase of VEGF Expression in the Hep3B Human Hepatoma Cells
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Kwon YW, Bae SK, Kim JA, Kim KW, Park BC
- KMID: 2175458
- J Korean Cancer Assoc.
- 1997 Apr;29(2):220-226.
PURPOSE: Hepatocellular carcinoma (HCC), a typical hypervasculized tumor is very sensitive to hypoxia and vascular endothelial growth factor (VEGF) has previously been identified to be up-regulated in response to hypoxia... -
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- The Regulation of AP-1 DNA Binding Activity by Long-term Nicotine Stimulation in Bovine Adrenal Medullary Chromaffin Cells: Role of Second Messengers
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Lee JK, Choi SS, Suh HW
- KMID: 1615000
- Korean J Physiol Pharmacol.
- 2002 Apr;6(2):109-112.
The signal pathways involved in the regulation of AP-1 DNA binding activity in long-term nicotine stimulated bovine adrenal medullary chromaffin (BAMC) cells have not been well characterized. To understand the... -
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- Signal transduction of cytokines in inducing matrix metalloproteinas-9 in myometrial smooth muscle cells from term pregnant women
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Seo YS, Baek GH, Heo JH, Yang SH, Kim JH, Bae DS, Roh CR
- KMID: 2076259
- Korean J Obstet Gynecol.
- 2001 May;44(5):938-945.
OBJECTIVE: To explore the intracellular signal transduction pathways of IL-1beta and TNF-alpha in inducing matrix metalloproteinase-9 (MMP-9) in human myometrial smooth muscle cells. METHODS: We studied the expression of MMP-9 induced... -
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- High Glucose Induces MCP-1 Expression in Cultured Human Mesangial Cells Partly Via Tyrosine Kinase-AP-1 Pathway
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Chang SP, Kim CS, Kim MJ, Kim SB, Lee SK, Park JS
- KMID: 2079179
- Korean J Nephrol.
- 2001 Jul;20(4):613-623.
Infiltration of circulating monocytes into glomeruli has been implicated in the pathogenesis of glomerular injury in many human and experimental forms of glomerulonephritis. Monocyte chemoattractant protein-1(MCP-1), a potent chemokine with... -
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