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Retinal Tissue Bioengineering, Materials and Methods for the Treatment of Glaucoma

Behtaj S, O¨ chsner A, Anissimov YG, Rybachuk M

BACKGROUND: Glaucoma, a characteristic type of optic nerve degeneration in the posterior pole of the eye, is a common cause of irreversible vision loss and the second leading cause of...
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Evaluation of Collagen Gel-Associated Human Nasal Septum- Derived Chondrocytes As a Clinically Applicable Injectable Therapeutic Agent for Cartilage Repair

Lim MH, Jeun JH, Kim DH, Park SH, Kim SJ, Lee WS, Hwang SH, Lim JY, Kim SW

BACKGROUND: Articular cartilage injury has a poor repair ability and limited regeneration capacity with therapy based on articular chondrocytes (ACs) implantation. Here, we validated the hypothesis that human nasal septum-derived...
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Channeling Effect and Tissue Morphology in a Perfusion Bioreactor Imaged by X-Ray Microtomography

Beauchesne CC, Chabanon M, Smaniotto B, Ladoux B, Goyeau B, David B

BACKGROUND: Perfusion bioreactors for tissue engineering hold great promises. Indeed, the perfusion of culture medium enhances species transport and mechanically stimulates the cells, thereby increasing cell proliferation and tissue formation....
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Correction to: Preconditioning of Human Decidua Basalis Mesenchymal Stem/Stromal Cells with Glucose Increased Their Engraftment and Anti-diabetic Properties

Basmaeil Y, Rashid MA, Khatlani T, AlShabibi M, Bahattab E, Abdullah ML, Abomaray F, Kalionis B, Massoudi S, Abumaree M

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Anti-Inflammatory Effect of Adipose-Derived Stromal Vascular Fraction on Osteoarthritic Temporomandibular Joint Synoviocytes

Kim H, Lee BK

BACKGROUND: Osteoarthritis (OA) in the temporomandibular joint (TMJ) in the TMJ (TMJ-OA) is difficult to treat, and new alternative treatments are needed. Recently, adipose-derived stem cells (ASCs) have been introduced...
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Hypoxia Pretreatment Promotes Chondrocyte Differentiation of Human Adipose-Derived Stem Cells via Vascular Endothelial Growth Factor

Hwang OK, Noh YW, Hong JT, Lee JW

BACKGROUND: Human adipose tissue-derived stem cells (ADSCs) are attractive multipotent stem cell sources with therapeutic potential in various fields requiring repair and regeneration, such as acute and chronically damaged tissues....
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Vitrified Human Umbilical Arteries as Potential Grafts for Vascular Tissue Engineering

Mallis P, Katsimpoulas M, Kostakis A, Dipresa D, Korossis S, Papapanagiotou A, Kassi E, Stavropoulos-Giokas C, Michalopoulos E

BACKGROUND The development of a biological based small diameter vascular graft (d\6 mm), that can be properly stored over a long time period at - 196 C, in order to...
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Multi-Spheroid-Loaded Human Acellular Dermal Matrix Carrier Preserves Its Spheroid Shape and Improves In Vivo Adipose- Derived Stem Cell Delivery and Engraftment

Kim JH, Lee JY

BACKGROUND: Current in vivo adult stem cell delivery presents limited clinical effects due to poor engraftment and survival. To overcome current challenges in cell delivery and promote surgical cell delivery...
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Engineered M13 Peptide Carrier Promotes Angiogenic Potential of Patient-Derived Human Cardiac Progenitor Cells and In Vivo Engraftment

Jang WB, Ji ST, Park JH, Kim YJ, Kang S, Kim DY, Lee NK, Kim JS, Lim HJ, Choi J, Le THV, Ly TTG, Rethineswaran VK, Kim DH, Ha JS, Yun J, Baek SH, Kwon SM

BACKGROUND: Despite promising advances in stem cell-based therapy, the treatment of ischemic cardiovascular diseases remains a big challenge due to both the insufficient in vivo viability of transplanted cells and...
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A Combinational Therapy of Articular Cartilage Defects: Rapid and Effective Regeneration by Using Low-Intensity Focused Ultrasound After Adipose Tissue-Derived Stem Cell Transplantation

Song BW, Park JH, Kim B, Lee S, Lim S, Kim SW, Choi JW, Lee J, Kang M, Hwang KC, Chae DS, Kim IK

BACKGROUND: Although low-intensity pulsed ultrasound has been reported to be potential cartilage regeneration, there still unresolved treatment due to cartilage fibrosis and degeneration by a lack of rapid and high-efficiency...
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Osteoblast-Based Therapy—A New Approach for Bone Repair in Osteoporosis: Pre-Clinical Setting

Mahmoud NS, Mohamed MR, Ali MAM, Aglan HA, Amr KS, Ahmed HH

BACKGROUND: Osteoporosis is a metabolic bone disease characterized by low bone density resulting in increased fracture susceptibility. This research was constructed to uncover the potential therapeutic application of osteoblasts transplantation,...
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Combination of Filtered Bone Marrow Aspirate and Biomimetic Scaffold for the Treatment of Knee Osteochondral Lesions: Cellular and Early Clinical Results of a Single Centre Case Series

Veber M, Vogler J, Knezˇevic´ M, Barlicˇ A, Drobnicˇ M

BACKGROUND: Osteochondral injury is a very common orthopaedic pathology, mainly affecting young, active population, with limited current treatment options. Herein we are presenting cellular and early clinical data of a...
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