- The effect of Thymidylate Synthetase extression in stomach cancer tissues on the prognosis
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Hong YS
- KMID: 2306300
- Korean J Med.
- 1999 Jun;56(6):782-782.
No abstract available. -
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- Effects of Lovastatin in Combination with 5-FU on Stomach Cancer Cells
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Park C, Kang WK
- KMID: 2059145
- J Korean Cancer Assoc.
- 1997 Oct;29(5):785-790.
No abstract available -
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- Expression of Thymidylate Synthase in Gastric Cancer
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Ko DG, Park CH, Ha DW, Seou HC, Kim DH
- KMID: 2209325
- J Korean Surg Soc.
- 2000 Dec;59(6):738-745.
PURPOSE: 5-fluorouracil is one of the widely used chemotherapeutic agent whose metabolic product forms tight covalent binding complex with thymidylate synthase (TS) and thereby blocks the DNA synthesis process. Expression... -
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- A practical approach for assessing chemosensitivity in colorectal cancer cell lines by comparative analysis of cell viability and thymidylate synthase mRNA expression
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Hwang HY
- KMID: 1437752
- J Korean Surg Soc.
- 2012 Jan;82(1):28-34.
- doi: 10.4174/jkss.2012.82.1.28
PURPOSE: The purpose of this study is to suggest a probable problem in chemosensitivity tests performed in practice and to speculate on practicable measures for more accurate chemosensitivity evaluation. METHODS: Three... -
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- Genetic Polymorphism of Thymidylate Synthase Enhancer Region (TSER) in Patients with Silent Brain Infarction
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Kim KK, Kim HS, Koo YH, Kim DG, Kim WC, Kim OJ, Kim NK
- KMID: 2343253
- J Korean Neurol Assoc.
- 2007 Aug;25(3):338-343.
BACKGROUND: Hyperhomocysteinemia is an independent risk factor for silent brain infarction (SBI). The plasma homocysteine (pHcy) level is influenced by the activities of enzymes such as 5,10-methylenetetrahydrofolate reductase (MTHFR). Thymidylate... -
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- The Expression of Thymidylate Synthase in Breast Cancer
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Park JK, Kim JS, Kim KH, Jeon HM, Suh YJ, Park WC, Oh SC, Jung SS, Kim JS, Im SA
- KMID: 2173618
- J Korean Breast Cancer Soc.
- 1999 Dec;2(2):227-239.
- doi: 10.4048/jkbcs.1999.2.2.227
Fluorouracil is well known as a standard chemotherapeutic drug in breast cancer and other cancers that is converted to flurodeoxyuridine monophosphate (FdUMP) and leads to the inhibition of thymidylate synthase... -
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- The Relationship between Thymidylate Synthase Expression and Prognosis in Gastric Adenocarcinoma
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Nam EM, Im SA, Lee SN, Koo HS
- KMID: 2080692
- Korean J Med.
- 1999 Mar;56(3):339-346.
OBJECTIVE: Gastric carcinoma is one of the most common cause of death in Korea with limited effectiveness of chemotherapy. Thymidylate synthase(TS) is a critical therapeutic target for the fluoropyrimidine cytotoxic drugs, that... -
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- The Relation between Microsatellite Instability and the Thymidylate Synthase Expression in Gastric Cancer
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Ko HS, Ahn CW, Kang HY, Kim KI, Hong SP, Ahn DH
- KMID: 2372914
- J Korean Gastric Cancer Assoc.
- 2008 Dec;8(4):169-175.
PURPOSE: The main target of 5-fluorouracil (5-FU) is thymidylate synthase (TS). A high TS expression has been identified as promoting resistance to 5-FU. For colorectal cancers, the response to 5-FU... -
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- Gastric Cancer Susceptibility according to Methylenetetrahydrofolate Reductase and Thymidylate Synthase Gene Polymorphism
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Jung H, Lee JI, Lee HH, Kim SH, Hur H, Jeon HM
- KMID: 1455484
- J Korean Surg Soc.
- 2010 Jul;79(1):27-34.
- doi: 10.4174/jkss.2010.79.1.27
PURPOSE: The genetic polymorphism and intracellular activity of methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) is clinically associated with carcinogenesis and biological therapeutic effect in gastrointestinal malignancies. We aimed to... -
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- A High Thymidylate Synthase Expression is Related to Better Outcome for Advanced Gastric Cancer Patients Treated with 5-FU Chemotherapy after Curative Resection
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Cho MY, Yi SY, Eom MS, Zhang SP, Kim HS, Lee JI, Kim DS
- KMID: 2277682
- Korean J Pathol.
- 2006 Apr;40(2):128-136.
BACKGROUND: The expressions of thymidylate synthase (TS), E2F-1, pRb, and p53 are correlated with DNA synthesis. The significance of their expressions is still controversial for predicting the outcome of 5-fluorouracil... -
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- Drug Resistance to 5 - Fluorouracil and Overexpression of Thymidylate Synthase mRNA in Human Gastrointestinal Malignancies
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Kim TY, Ryoo BY, Im YH, Kang YK, Lee SJ, Bang YJ, Kim NK
- KMID: 2137110
- J Korean Cancer Assoc.
- 2000 Feb;32(1):44-52.
PURPOSE: The cytotoxicity by 5-fluorouracil (5-FU) is mediated by inhibition of thymi- dylate synthase (TS), which is a rate-limiting enzyme for DNA synthesis. To test whether the resistance to 5-FU would be... -
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- Thymidylate Synthase Expression Using Immunohistochemical Staining in Colorectal Cancer
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An CH, Seo HJ, Kim KH, Oh ST, Kim JS, Jeon HM, Lim KW, Lee EJ
- KMID: 2026070
- J Korean Soc Coloproctol.
- 2001 Dec;17(6):316-323.
PURPOSE: Thymidylate synthase (TS) is a critical enzyme in the DNA synthesis and an important target of cancer chemotherapeutic agents, such as 5-fluorouracil (5-FU). Recent studies suggest that TS expression... -
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- Relationship between Expression of Thy- midylate Synthase mRNA and Resistance of Colon and Gastric Cancer Cells to 5-FU
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Cho SH, Min YD, Lee TB, Choi SM, Byun IG, Choi CH, Kim KJ
- KMID: 2334297
- J Korean Soc Coloproctol.
- 2003 Apr;19(2):67-73.
PURPOSE: Thymidylate synthase (TS) is an important target for chemotherapeutic drugs such as 5-fluorouracil (5-FU). Overexpression of TS has been linked to chemotherapy resistance, but their relationship was not completely... -
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- Efficacy of Pemetrexed in Relapsed Non-Small Cell Lung Cancer and Thymidylate Synthase Expression
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Park CK, Kim KS, Oh IJ, Tseden-Ish M, Choi YD, Kwon YS, Kim YI, Lim SC, Kim YC
- KMID: 2319223
- Tuberc Respir Dis.
- 2009 Sep;67(3):191-198.
BACKGROUND: Pemetrexed, a multi-targeted antifolate has been used as a second line treatment against non-small cell lung cancer (NSCLC). We aimed to clarify the efficacy and survival according to line... -
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- Expression of Thymidylate Synthase in Non-Small Cell Lung Cancer
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Yoo J, Kim S, Shim BY, Kim SH, Song SH, Cho DG, Ahn MI, Kim CH, Cho KD, Kang SJ, Kim HK
- KMID: 2073756
- Korean J Pathol.
- 2005 Dec;39(6):412-417.
BACKGROUND: Thymidylate synthase (TS) catalyzes the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), and this is an essential step in DNA biosynthesis. The present investigation was designed... -
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- Significance of Thymidylate Synthase Expression in Colorectal Cancer
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Min BW, Hong JH, Lee KB, Moon HY
- KMID: 2324979
- J Korean Surg Soc.
- 2002 May;62(5):408-414.
PURPOSE: Thymidylate synthase (TS) is the target enzyme for 5-fluorouracil (5-FU). It is known that TS is related to response, and resistance, following chemotherapy due to colorectal cancer. The object... -
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- Thymidylate Synthase Gene Polymorphism as a Prognostic Factor for the Colorectal Cancer
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Kim JH, Kim YB, Choi JH, Kim JM, Jeong SH, Suh KW
- KMID: 1835445
- J Korean Soc Coloproctol.
- 2004 Jun;20(3):151-156.
PURPOSE: Thymidylate synthase (TS) expression in colorectal cancer is regarded as both a prognostic marker and a predictor of response to fluoropyrimidine-based therapies targeting TS. However, results from immunohistochemical staining... -
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- Fibroblast growth factor-induced Thymidylate Synthase activity and expression in the serum-starved UMR 106-01 osteoblast cells
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Kim SW, Hwang OY, Lee JD, Song KY, Kim DH, Hong HN, Chang JS, Um KH, Lee SJ
- KMID: 2199131
- J Korean Orthop Res Soc.
- 2000 Oct;3(2):140-147.
PURPOSE: In the present study, the effects of bFGF on the early responses of proliferation of UMR 106-01 osteoblast cells during cell cycle reentry from the latent(G0/G1) to the proliferative... -
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- Genetic Analysis of Epstein-Barr Virus Latent Membrane Protein 1 and Immunohistochemical Expression of Transforming Growth Factor (TGF)-beta1, TGF-betaRII, p21, p16, E2F1, Thymidylate Synthase, and NF-kappaB in Epstein-Barr Virus Encoded RNA-positive Gastric Adenocarcinoma
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Cho MY, Eom M, Park KH, Kim MD, Sung SH, Kim MS, Kim DS, Choi SJ
- KMID: 2277664
- Korean J Pathol.
- 2006 Jun;40(3):176-184.
BACKGROUND :Although clinicopathologic differences have been described between Epstein-Barr virus (EBV)-positive and negative gastric adenocarcinomas, the pathogenetic basis for these differences remains unclear. In this study, efforts were made to... -
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- The Relationship of Methylenetetrahydrofolate Reductase(MTHFR) C677T, Thymidylate Synthase(TS) Gene Polymorphism and Epilepsy
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Lee IH, Kim HS, Kim WC, Kim NK, Han IB, Kim SH, Kwak YT, Kim OJ
- KMID: 1816504
- J Korean Epilepsy Soc.
- 2006 Jun;10(1):11-17.
PURPOSE: Thymidylate synthase (TS) gene encodes a tightly regulated enzyme that catalyzes the conversion of deoxyuridylate to thymidylate, and contains a tandem repeat polymorphism, of which a triple repeat is... -
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