- Development of inhibitors of pyrimidine metabolism
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Cha S
- KMID: 1105559
- Yonsei Med J.
- 1989 Dec;30(4):315-326.
- doi: 10.3349/ymj.1989.30.4.315
Benzylacyclouridines were developed as specific and potent competitive inhibitors of uridine phosphorylase with Ki values in the nanomolar range. These compounds have no activity against thymidine phosphorylase, uridine kinase,... -
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- Immunohistochemical Study on the Expression of Thymidine Phosphorylase and Ki-67 in the Uterine Cervical Neoplasia
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Jun S, Han HS, Kim CJ, Bae DH, Kim MK
- KMID: 2270300
- Korean J Obstet Gynecol.
- 2002 Jun;45(6):1033-1039.
OBJECTIVE: We evaluated the relationship between the expression of Ki-67 and thymidine-phosphorylase (TP) according to the cancerous progression of uterine cervical cancer with immunohistochemical method. METHODS: The material was obtained... -
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- Expression of thymidine phosphorylase in cervical neoplasia: correlation with clinicopathological prognostic factors
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Choi EK, Kim JW, Lee YJ, Lee JG, Kim DK, Kim YT, Cho NH
- KMID: 2076203
- Korean J Obstet Gynecol.
- 2001 Mar;44(3):550-557.
OBJECTIVES: Angiogenesis is a critical factor in the progression of solid tumors, including cervical cancer. However, the association between the expression of thymidine phosphorylase(TP) and clinicopathological factors has scarcely been... -
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- Thymidine Phosphorylase Expression in Progression of Cervical Lesions: Histological Features and Microvessel Density
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Yoon JH, Choi H, Lee SK, Kim SH, Lee JH, Kim SB
- KMID: 2077520
- Korean J Obstet Gynecol.
- 2005 Dec;48(12):2857-2866.
OBJECTIVE: The object of this study was to clarify the association of thymidine phosphorylase (TP) assessed in cancer cells and in stromal cells, with clinico-pathological factors including tumor angiogenesis and... -
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- The Schedule Dependency for Induction of Thymidine Phosphorylase Activity and the Enhancement of Capecitabine Efficacy by Docetaxel on the SNU-484 Gastric Cancer Cell Line That was Injected into Xenografted Nude Mice
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Suh SB, Suh BJ, Kim JH, Yoo HJ
- KMID: 2211126
- J Korean Surg Soc.
- 2007 Oct;73(4):294-301.
PURPOSE: Docetaxel (Taxotere(R)) and capecitabine are used in combination to treat advanced gastric cancer. Thymidine phosphorylase (TP) is an essential enzyme for the activation of capecitabine in tumors. This study... -
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- Expression of Thymidine Phosphorylase in Human Gastric Carcinoma
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Kim KH, Park CH, Kim JS, Lim KW
- KMID: 1844193
- J Korean Surg Soc.
- 2004 Jul;67(1):18-24.
PURPOSE: Angiogenesis plays an important role in the growth and metastasis of solid tumors. It has been recently reported that thymidine phosphorylase (dThdPase) is identical to platelet-derived endothelial cell growth... -
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- Expression of vascular endothelial growth factor and thymidine phosphorylase in cervical neoplasia and its clinical implication
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Choi EK, Kim JW, Kim YT, Kim DK, Cho NH, Jeong CJ
- KMID: 2262339
- Korean J Obstet Gynecol.
- 2001 Aug;44(8):1426-1436.
OBJECTIVES: The objective of this study is to evaluate the expression of vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP), and to correlate them with clinicopathological factors in uterine... -
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- Functional Modification of a Specific RNA with Targeted Trans-Splicing
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Park YH, Kim SC, Kwon BS, Jung HS, Kimm K, Lee SW
- KMID: 1974010
- Genomics Inform.
- 2004 Mar;2(1):45-52.
The self-splicing group I intron from Tetrahymena thermophila has been demonstrated to perform splicing reaction with its substrate RNA in the trans configuration. In this study, we explored the potential... -
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- Nutrition Therapy for Mitochondrial Neurogastrointestinal Encephalopathy with Homozygous Mutation of the TYMP Gene
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Wang J, Chen W, Wang F, Wu D, Qian J, Kang J, Li H, Ma E
- KMID: 2279359
- Clin Nutr Res.
- 2015 Apr;4(2):132-136.
- doi: 10.7762/cnr.2015.4.2.132
Mitochondrial neurogastrointestinal encephalopathy (MNGIE) is characterized by significant gastrointestinal dysmotility. Early and long-term nutritional therapy is highly recommended. We report a case of MNGIE in a patient who was undergoing... -
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- Choice of Capecitabine or S1 in Combination with Oxaliplatin based on Thymidine Phosphorylase and Dihydropyrimidine Dehydrogenase Expression Status in Patients with Advanced Gastric Cancer
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Xu R, He X, Wufuli R, Su Y, Ma L, Chen R, Han Z, Wang F, Liu J
- KMID: 2466029
- J Gastric Cancer.
- 2019 Dec;19(4):408-416.
- doi: 10.5230/jgc.2019.19.e40
PURPOSE: To study the efficacy of capecitabine or S-1 plus oxaliplatin (CAPOX or SOX) for treating thymidine phosphorylase (TP)- or dihydropyrimidine dehydrogenase (DPD)-positive advanced gastric cancer. MATERIALS AND METHODS: Eighty-six patients... -
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- Thymidylate Synthase, Thymidine Phosphorylase, VEGF and p53 Protein Expression in Primary Colorectal Cancer for Predicting Response to 5-fluorouracil-based Chemotherapy
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Ahn MJ, Choi JH, Oh HS, Lee YY, Kim IS, Choi IY, Lee KH, Song KW, Park CK
- KMID: 1804574
- Cancer Res Treat.
- 2005 Aug;37(4):216-222.
PURPOSE: In the treatment of advanced metastatic colorectal cancer, several new agents, such as irinotecan and oxaliplatin, have been developed, which have improved both disease free and overall survivals. Among... -
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- The Expression of Thymidine Phosphorylase in Cancer-infiltrating Inflammatory Cells in Stomach Cancer
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Jang JS, Lee WS, Lee JS, Kim HW, Ko GH, Ha WS
- KMID: 1785798
- J Korean Med Sci.
- 2007 Sep;22(Suppl):S109-S114.
- doi: 10.3346/jkms.2007.22.S.S109
Thymidine phosphorylase (TP) has shown to be up-regulated in several cancers and to play a role in angiogenesis and invasion. Most studies regarding TP have focused on cancer cells. Recently,... -
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- Inhibition of Tumor Growth and Angiogenesis by KJ3, Betulinic Acid, and Fumagillin in Mouse Neuroblastoma
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Choi SH, Lee JH, Hwang EH
- KMID: 2328692
- J Korean Assoc Pediatr Surg.
- 2002 Dec;8(2):101-106.
The antiangiogenic effects of novel agent KJ3, Betulinic acid, and Fumagillin on the neovascularization were studied by examining ultrastructural alterations in the vasculature of synthetic gelform and mouse neuroblastoma C1300.... -
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- Thymidine phosphrylase (TP) in cancer-infiltrating inflammatory cells in stomach cancer: the significance of TP in prognosis and tumor angiogenesis
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Lee WS, Kim DH, Kang KM, Kim HW, Jang JS, Lee JS, Ko GH, Ha WS
- KMID: 2252434
- Korean J Med.
- 2005 May;68(5):504-510.
BACKGROUND: Thymidine phosphorylase (TP) is an enzyme catalyzing the reversible phosphorolysis of thymidine to thymine and 2-deoxyribose-1-phosphate. TP plays a role in angiogenesis. Evidences suggest that infiltrating inflammatory cells adjacent... -
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- The Efficacy of Oral Combination Chemotherapy of 5'-DFUR and Cyclophosphamide for Metastatic Breast Cancer
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Park MH, Yoon JH, Jegal YJ
- KMID: 2286656
- J Breast Cancer.
- 2006 Sep;9(3):249-253.
- doi: 10.4048/jbc.2006.9.3.249
PURPOSE: A sufficient response rate and good compliance are both important for instituting chemotherapy to treat metastatic breast cancer. Effective oral chemotherapy regimens have long been studied to improve patients'... -
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- ERCC1 Can Be a Prognostic Factor in Hilar Cholangiocarcinoma and Extrahepatic Bile Duct Cancer, But Not in Intrahepatic Cholangiocarcinoma
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Park KW, Jung ES, Kim DG, Yoo YK, Hong TH, Lee IS, Koh YH, Kim JH, Lee MA
- KMID: 2167609
- Cancer Res Treat.
- 2013 Mar;45(1):63-69.
PURPOSE: There are three types of bile duct cancer, intrahepatic cholangiocarcinoma (ICC), hilar cholangiocarcinoma (HC), and extrahepatic cholangiocarcinoma (EHC). Despite different clinical presentation, the same protocol has been used in... -
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- Expression of Vascular Endothelial Growth Factor and Platelet-Derived Endothelial Cell Growth Factor in Head and Neck Squamous Cell Carcinoma and It's Relation to Angiogensis
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Choi HS, Kim YB, Song YH, Hong NP, Ahn HY, Kim YH
- KMID: 2274748
- Korean J Otolaryngol-Head Neck Surg.
- 2000 Aug;43(8):854-861.
BACKGROUND AND OBJECTIVES: Tumor angiogenesis is an essential process required for growth and metastasis in cancer. Vascular endothelial growth Factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) are known... -
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- Expression of VEGF and PD-ECGF, and Proliferative Activity of Ki-67 according to Clinicopathologic Feature in Cervical Tumor
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Lee MG, Koo TB, Park IS
- KMID: 1980071
- Korean J Gynecol Oncol Colposc.
- 2000 Sep;11(3):290-300.
OBJECTIVE: The objective of this study is to evaluate the expressions, microvessel counts and angiogenic pathway of VEGF and PD-ECGF and proliferative activity of Ki-67 according to clinicopathologic feature... -
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- Expression of Basic Fibroblast Growth Factor(bFGF), Vascular Endothelial Growth Factor(VEGF), and Platelet-Derived Endothelial Cell Growth Factor(PD-ECGF) in Nasal Polyps
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Park SK, Heo KW
- KMID: 1923197
- Korean J Otolaryngol-Head Neck Surg.
- 2001 Dec;44(12):1275-1282.
BACKGROUND AND OBJECTIVES : The etiology of polyp is still largely unknown. Vascular remodelling, with local angiogenesis and plasma leakage, could play a role in the growth process of nasal... -
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- Relationship between the Expression of Platelet-Derived Endothelial Cell Growth Factor(PD-ECGF), Basic Fibroblast Growth Factor(bFGF), Vascular Endothelial Growth Factor(VEGF) and Clinical Stage in Squamous Cell Carcinoma of Larynx
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Kim HS, Heo KW, Lee MH, Park SG, Eom JW
- KMID: 1610882
- Korean J Otolaryngol-Head Neck Surg.
- 2002 May;45(5):488-494.
BACKGROUND AND OBJECTIVES: Normal angiogenesis occurs as a part of the body's repair processes like the healing of wounds and fractures. By contrast, uncontrolled angiogenesis can often be pathological. Vascular... -
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