- Glycogen Synthase Kinase 3 Inactivation Induces Cell Senescence through Sterol Regulatory Element Binding Protein 1-Mediated Lipogenesis in Chang Cells
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Kim YM, Song I, Seo YH, Yoon G
- KMID: 2169308
- Endocrinol Metab.
- 2013 Dec;28(4):297-308.
- doi: 10.3803/EnM.2013.28.4.297
BACKGROUND: Enhanced lipogenesis plays a critical role in cell senescence via induction of expression of the mature form of sterol regulatory element binding protein 1 (SREBP1), which contributes to an... -
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- Quercetin induces cell death in cervical cancer by reducing O-GlcNAcylation of adenosine monophosphate-activated protein kinase
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Ali A, Kim MJ, Kim MY, Lee HJ, Roh GS, Kim HJ, Cho GJ, Choi WS
- KMID: 2430195
- Anat Cell Biol.
- 2018 Dec;51(4):274-283.
- doi: 10.5115/acb.2018.51.4.274
Hyper-O-GlcNAcylation is a general feature of cancer which contributes to various cancer phenotypes, including cell proliferation and cell growth. Quercetin, a naturally occurring dietary flavonoid, has been reported to reduce... -
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- Carnosic Acid Inhibits Lipid Accumulation in 3T3-L1 Adipocytes Through Attenuation of Fatty Acid Desaturation
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Park MY, Sung MK
- KMID: 2171316
- J Cancer Prev.
- 2015 Mar;20(1):41-49.
- doi: 10.15430/JCP.2015.20.1.41
BACKGROUND: Excess body fat accumulation contributes to the development of metabolic disorders that can cause adverse health effects. Carnosic acid (CA), a major bioactive component of rosemary (Rosemarinus officinalis), has... -
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- The Effects of Genistein to Expression of Fatty Acid Synthase in Breast Cancer Cells
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Ra YM, Yim JS, Song KH, Ko DG, Choi IS, Choi WJ, Yoon DS
- KMID: 1745053
- J Breast Cancer.
- 2007 Jun;10(2):127-133.
- doi: 10.4048/jbc.2007.10.2.127
PURPOSE: The relatively low incidence of breast cancer in Asian countries with cultures which traditionally eat a large amount of soy is worth noticing in research fields. Genistein is a... -
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- Leucrose, a Sucrose Isomer, Suppresses Hepatic Fat Accumulation by Regulating Hepatic Lipogenesis and Fat Oxidation in High-fat Diet-induced Obese Mice
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Lee J, Kim E, Kim Y, Yoo SH
- KMID: 2417374
- J Cancer Prev.
- 2018 Jun;23(2):99-106.
- doi: 10.15430/JCP.2018.23.2.99
Obesity is currently one of the most serious public health problems and it can lead to numerous metabolic diseases. Leucrose, d-glucopyranosyl-α-(1-5)-d-fructopyranose, is an isoform of sucrose and it is naturally... -
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- The effects of black garlic (Allium satvium) extracts on lipid metabolism in rats fed a high fat diet
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Ha AW, Ying T, Kim WK
- KMID: 2313806
- Nutr Res Pract.
- 2015 Feb;9(1):30-36.
- doi: 10.4162/nrp.2015.9.1.30
BACKGROUD/OBEJECTIVES: The mechanism of how black garlic effects lipid metabolism remains unsolved. Therefore, the objectives of this study were to determine the effects of black garlic on lipid profiles and... -
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- Over-expression of Liver X Receptor-alpha(LXR alpha by TO901317 Exaggerated the Production of Mesangial Matrix
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Chin HJ, Fu YY, Song YR, Lee ES, Lee YM, Kim SG, Na KY, Kim S, Chae DW
- KMID: 2253063
- Korean J Nephrol.
- 2010 Mar;29(2):189-197.
PURPOSE: To provide the insight into the role of LXR alpha on the progression of diabetic nephropathy, we measured the production of extracellular matrix in the cultured mesangial cells treated... -
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- The effect of fucoxanthin rich power on the lipid metabolism in rats with a high fat diet
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Ha AW, Kim WK
- KMID: 2313682
- Nutr Res Pract.
- 2013 Aug;7(4):287-293.
This study determined the effects of fucoxanthin on gene expressions related to lipid metabolism in rats with a high-fat diet. Rats were fed with normal fat diet (NF, 7% fat)... -
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- Picroside II attenuates fatty acid accumulation in HepG2 cells via modulation of fatty acid uptake and synthesis
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Dhami-Shah H, Vaidya R, Udipi S, Raghavan S, Abhijit S, Mohan V, Balasubramanyam M, Vaidya A
- KMID: 2429085
- Clin Mol Hepatol.
- 2018 Mar;24(1):77-87.
- doi: 10.3350/cmh.2017.0039
BACKGROUND/AIMS: Hepatic steatosis is caused by an imbalance between free fatty acids (FFAs) uptake, utilization, storage, and disposal. Understanding the molecular mechanisms involved in FFAs accumulation and its modulation could... -
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- Cilostazol inhibits insulin-stimulated expression of sterol regulatory binding protein-1c via inhibition of LXR and Sp1
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Jung YA, Kim HK, Bae KH, Seo HY, Kim HS, Jang BK, Jung GS, Lee IK, Kim MK, Park KG
- KMID: 2155338
- Exp Mol Med.
- 2014 Jan;46(1):e73.
- doi: 10.1038/emm.2013.143
Hepatic steatosis is common in obese individuals with hyperinsulinemia and is an important hepatic manifestation of metabolic syndrome. Sterol regulatory binding protein-1c (SREBP-1c) is a master regulator of lipogenic gene... -
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- Effects of Lonicera caerulea extract on adipocyte differentiation and adipogenesis in 3T3-L1 cells and mouse adipose-derived stem cells (MADSCs)
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Park M, Lee C, Lee HJ
- KMID: 2466679
- J Nutr Health.
- 2019 Feb;52(1):17-25.
- doi: 10.4163/jnh.2019.52.1.17
PURPOSE: Obesity is a major health problem of global significance because it is clearly associated with an increased risk of health problems, such as nonalcoholic fatty liver disease (NAFLD), diabetes,... -
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- Ethanol extract of Allium fistulosum inhibits development of non-alcoholic fatty liver disease
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Hwang JT, Shin EJ, Chung MY, Park JH, Chung S, Choi HK
- KMID: 2407807
- Nutr Res Pract.
- 2018 Apr;12(2):110-117.
- doi: 10.4162/nrp.2018.12.2.110
BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and is closely associated with metabolic syndrome. In the present study, we observed the effect of... -
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- Bioconversion of Citrus unshiu peel extracts with cytolase suppresses adipogenic activity in 3T3-L1 cells
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Lim H, Yeo E, Song E, Chang YH, Han BK, Choi HJ, Hwang J
- KMID: 2313883
- Nutr Res Pract.
- 2015 Dec;9(6):599-605.
- doi: 10.4162/nrp.2015.9.6.599
BACKGROUND/OBJECTIVES: Citrus flavonoids have a variety of physiological properties such as anti-oxidant, anti-inflammation, anti-cancer, and anti-obesity. We investigated whether bioconversion of Citrus unshiu with cytolase (CU-C) ameliorates the anti-adipogenic effects... -
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- Effects of Alpha-lipoic Acid on SREBP-1c Expression in HepG2 Cells
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Yun TS, Min AK, Kim NK, Kim MK, Cho HC, Kim HS, Hwang JS, Ryu SY, Park KG, Lee IK
- KMID: 2063547
- J Korean Endocr Soc.
- 2008 Feb;23(1):27-34.
- doi: 10.3803/jkes.2008.23.1.27
BACKGROUND: Non-alcoholic fatty liver disease is common in patients with insulin resistance. Sterol regulatory element binding protein-1c (SREBP-1c) is a member of a family of transcription factors that have been... -
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- Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice
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Kim KE, Kim H, Heo RW, Shin HJ, Yi CO, Lee DH, Kim HJ, Kang SS, Cho GJ, Choi WS, Roh GS
- KMID: 2285590
- Korean J Physiol Pharmacol.
- 2015 Sep;19(5):451-460.
- doi: 10.4196/kjpp.2015.19.5.451
Sirtuin 1 (SIRT1) is a mammalian NAD+-dependent protein deacetylase that regulates cellular metabolism and inflammatory response. The organ-specific deletion of SIRT1 induces local inflammation and insulin resistance in dietary and... -
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- Effects of Panicum miliaceum L. extract on adipogenic transcription factors and fatty acid accumulation in 3T3-L1 adipocytes
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Park MY, Seo DW, Lee JY, Sung MK, Lee YM, Jang HH, Choi HY, Kim JH, Park DS
- KMID: 2313517
- Nutr Res Pract.
- 2011 Jun;5(3):192-197.
The dietary intake of whole grains is known to reduce the incidence of chronic diseases such as obesity, diabetes, cardiovascular disease, and cancer. To investigate whether there are anti-adipogenic activities... -
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- Red pepper seed water extract inhibits preadipocyte differentiation and induces mature adipocyte apoptosis in 3T3-L1 cells
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Kim HJ, You MK, Lee YH, Kim HJ, Adhikari D, Kim HA
- KMID: 2448694
- Nutr Res Pract.
- 2018 Dec;12(6):494-502.
- doi: 10.4162/nrp.2018.12.6.494
BACKGROUND/OBJECTIVES: Reducing the number of adipocytes by inducing apoptosis of mature adipocytes as well as suppressing differentiation of preadipocytes plays an important role in preventing obesity. This study examines the... -
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- Histone deacetylase inhibition attenuates hepatic steatosis in rats with experimental Cushing's syndrome
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Kim M, Lee HA, Cho HM, Kang SH, Lee E, Kim IK
- KMID: 2398552
- Korean J Physiol Pharmacol.
- 2018 Jan;22(1):23-33.
- doi: 10.4196/kjpp.2018.22.1.23
Cushing's syndrome (CS) is a collection of symptoms caused by prolonged exposure to excess cortisol. Chronically elevated glucocorticoid (GC) levels contribute to hepatic steatosis. We hypothesized that histone deacetylase inhibitors... -
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- Pear pomace water extract inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes
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Rhyu J, Kim MS, You MK, Bang MA, Kim HA
- KMID: 2313708
- Nutr Res Pract.
- 2014 Feb;8(1):33-39.
Obesity occurs when a person's calorie intake exceeds the amount of energy burns, which may lead to pathologic growth of adipocytes and the accumulation of fat in the tissues. In... -
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- Reciprocal Deletion and Duplication of 17p11.2-11.2: Korean Patients with Smith-Magenis Syndrome and Potocki-Lupski Syndrome
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Lee CG, Park SJ, Yun JN, Yim SY, Sohn YB
- KMID: 2157987
- J Korean Med Sci.
- 2012 Dec;27(12):1586-1590.
- doi: 10.3346/jkms.2012.27.12.1586
Deletion and duplication of the -3.7-Mb region in 17p11.2 result in two reciprocal syndrome, Smith-Magenis syndrome and Potocki-Lupski syndrome. Smith-Magenis syndrome is a well-known developmental disorder. Potocki-Lupski syndrome has recently... -
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