- E1B-19k does not Localize in Mitochondria nor Dimerize Bax even with the Staurosporine
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Yoon SH, Kim JY, Park SW, Ahn YH, Ahn YM, Cho KH, Cho KG
- KMID: 1547606
- J Korean Neurosurg Soc.
- 2000 Jun;29(6):725-730.
No abstract available. -
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- Staurosporine Induces ROS-Mediated Process Formation in Human Gingival Fibroblasts and Rat Cortical Astrocytes
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Lee HG, Kim DS, Moon SA, Kang JW, Seo JT
- KMID: 1789366
- Int J Oral Biol.
- 2015 Mar;40(1):27-33.
- doi: 10.11620/IJOB.2015.40.1.027
In the present study, we investigated the effect of staurosporine on the formation of cellular processes in human gingival fibroblasts and rat astrocytes. Staurosporine caused a rapid induction of process... -
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- Staurosporine and cytochalasin D induce chondrogenesis by regulation of actin dynamics in different way
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Kim M, Song K, Jin EJ, Sonn J
- KMID: 1389731
- Exp Mol Med.
- 2012 Sep;44(9):521-528.
Actin cytoskeleton has been known to control and/or be associated with chondrogenesis. Staurosporine and cytochalasin D modulate actin cytoskeleton and affect chondrogenesis. However, the underlying mechanisms for actin dynamics regulation... -
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- Calcium overload is essential for the acceleration of staurosporine-induced cell death following neuronal differentiation in PC12 cells
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Seo SR, Seo JT
- KMID: 1088602
- Exp Mol Med.
- 2009 Apr;41(4):269-276.
- doi: 10.3858/emm.2009.41.4.030
Differentiation of neuronal cells has been shown to accelerate stress-induced cell death, but the underlying mechanisms are not completely understood. Here, we find that early and sustained increase in cytosolic... -
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- The Changes of Cell Cycle Phase Fractions and Expression of p53 by the Treatment of Staurosporine in MCF-7 Cell Line
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Nam J, Yea KA, Lee HN, Jo HH, Ryu KS, Lew YO, Rha JG, Han KT
- KMID: 2076195
- Korean J Obstet Gynecol.
- 2001 Mar;44(3):501-505.
OBJECTIVE: We investigated the effects on the cell cycle and p53 expression by the treatment of various concentrations of staurosporine to elucidate the molecular mechanism of staurosporine induced cell cycle... -
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- PKC-Independent Stimulation of Cardiac Na+/Ca2+ Exchanger by Staurosporine
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Kang TM
- KMID: 1486108
- Korean J Physiol Pharmacol.
- 2008 Oct;12(5):259-265.
- doi: 10.4196/kjpp.2008.12.5.259
[Ca2+]i transients by reverse mode of cardiac Na+/Ca2+ exchanger (NCX1) were recorded in fura-2 loaded BHK cells with stable expression of NCX1. Repeated stimulation of reverse NCX1 produced a long-lasting... -
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- Effect of staurosporine on the long-term secretion of catecholamines induced by various secretagogues in cultured bovine adrenal medullary chromaffin cells
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Choi SS, Suh HW
- KMID: 1607139
- Korean J Physiol Pharmacol.
- 2001 Dec;5(6):503-510.
Long-term treatment of cultured bovine adrenal medullary chromaffin (BAMC) cells with arachidonic acid (100 muM), angiotesnin II (100 nM), prostaglandin E2 (PGE2; 10 muM), veratridine (2 muM) or KCl (55... -
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- Selective Protection of Normal Proliferationg Cells Against Anti-Neoplastic Chemotherapy by Stausporine Pretreatment
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Jung SH, Kwon MK, Jo YS, Song MK, Ryu KS, Rha JG, Han KT
- KMID: 2272150
- Korean J Obstet Gynecol.
- 2003 Sep;46(9):1680-1692.
OBJECTIVE: A major limiting factor in human cancer chemotherapy is toxicity in normal cells and tissues. Our goal was to determine whether normal proliferating cells could be protected from chemotherapeutic... -
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- Ischemic Preconditioning and the Role of Protein Kinase C in Cultured Retinal Ganglion Cell Line
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Na KD, Kang SY, Seong GJ, Hong S, Chun MJ, Kim CY
- KMID: 2110880
- J Korean Ophthalmol Soc.
- 2008 Jun;49(6):979-986.
- doi: 10.3341/jkos.2008.49.6.979
PURPOSE: To investigate the cellular protective effects of hypoxic preconditioning against oxidative stress in a staurosporine-differentiated RGC-5 cell line and the relevance of protein kinase C subtype expression. METHODS: The minimum... -
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- Calbindin-D28K Prevents Staurosporin-induced Bax Cleavage and Membrane Permeabilization
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Choi WS, Oh YJ
- KMID: 2165519
- Exp Neurobiol.
- 2014 Jun;23(2):173-177.
- doi: 10.5607/en.2014.23.2.173
Calbindin-D28K has been implicated in the regulation of neuronal cell death. Previously, we demonstrated that calbindin-D28K prevents staurosporine (STS)-induced caspase activation and subsequent apoptosis in a neuronal cell line. However,... -
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- Effect of Protein Kinase C Inhibitor (Staurosporine) in Human Invasive Bladder Tumor Cells
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Kim CS, Choi EH, Park HK, Kim KS, Hwang O, Lee I
- KMID: 2060602
- Korean J Urol.
- 1995 Aug;36(8):795-801.
Protein Kinase C which is a Ca++ -activated, phospholipid - dependent enzyme phosphorylates numerous protein substrates and participates in intracellular signaling processes. Protein kinase C is associated with a wide... -
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- Comparison of regulatory action of cAMP and cGMP on the activation of neutrophil responses
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Han CH, Yoon YC, Shin YK, Han ES, Lee CS
- KMID: 2285164
- Korean J Physiol Pharmacol.
- 1997 Feb;1(1):97-105.
The regulatory role of cyclic nucleotides in the expression of neutrophil responses has been examined. fMLP-stimulated superoxide production in neutrophils was inhibited by dibutyryl adenosine 3',5'-cyclic monophosphate (DBcAMP), histamine, adenosine + theophylline, cAMP elevating... -
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- Effects of Protein kinase C Modulators on the Ischemic Damage of PC12 Cell
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Chung JY, Lee SH, Kim Y, Cho IC, Lee KY
- KMID: 1807456
- Chonnam Med J.
- 2000 Jun;36(2):149-157.
Ischemia-induced cellular responses are now major concern over various medical fields such as organ transplantation, brain apoplexy, and coronary arterial diseases, etc. PKC pathway, a major component of signal transductions,... -
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- Tetrachloroauric acide depresses the activation processes of phagocytic cells
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Lee CS
- KMID: 1849846
- Korean J Physiol Pharmacol.
- 1998 Jun;2(3):377-384.
Gold compounds depress phagocytic cell responses, including chemotaxis, and respiratory burst. However, the effects of gold compounds on the function of phagocytic cells are variable according to the preparation of medicine. In this... -
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- Both R(-)- and S(+)-Citalopram Attenuate Neuronal Apoptosis in Murine Cortical Cell Culture
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Eu MY, Chung YK, Noh JS
- KMID: 2287390
- Korean J Psychopharmacol.
- 2009 Nov;20(6):301-306.
OBJECTIVE: Several lines of evidence have shown that neuronal injury might represent a possible pathway to mood disorders. The present study was performed to examine the possibility that the neuroprotective... -
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- Depression of Ca2+ influx in complement C5a-stimulated neutrophils by calmodulin inhibitors
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Ham DS, Kim HH, Han ES, Lee CS
- KMID: 2071531
- Korean J Physiol Pharmacol.
- 1998 Feb;2(1):109-117.
Role of Ca2+/calmodulin complex in intracellular Ca2+ mobilization in neutrophils has not been clearly elucidated. In this study, effects of chlorpromazine, trifluoperazine and imipramine on the intracellular Ca2+ mobilization, including Ca2+ influx, in... -
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- Effect of Galectin-3 Gene Transfer for the Apoptosis and Cell Growth of the Prostate Cancer Cell Line (LNCaP Cells)
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Kim DS, Cho ST, Cho MJ, Lee YG
- KMID: 2293816
- Korean J Urol.
- 2005 Dec;46(12):1354-1359.
PURPOSE: Galectin-3 is a member of a large family of beta-galactoside- binding animal lectins. It is thought that galectin-3 can be a suppressor of apoptosis because of its significant sequence... -
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- Intracellular signal transduction of interleukin-6 production bylipopolysaccharide-stimulated fibroblasts
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Joo JH, Ki SY, Moon SH, Jung SH, Kim HT, Uh ST, Kim YH, Park CS
- KMID: 2143163
- Korean J Med.
- 1998 Mar;54(3):415-422.
OBJECTIVES: Stimulation of cell results in a variety of early biochemical events, known as signal transduction pathway and ultimately leads to final outcome like cell proliferation or cytokine production. The... -
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- Phorbol Esters Attenuate The Action of Isoproterenol on Vascular Smooth Muscle
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Kim BY, Lee YW
- KMID: 2187899
- J Korean Neurosurg Soc.
- 1995 Jul;24(7):743-752.
The effects of phorbol esters were studied in rabbit carotid artery to evaluate the action of protein kinase C on the regulation of vascular tone by isoproterenol. The vascular rings,... -
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- Regulation of RANTES and MCP Expression in Human Nasal Mucosal Fibroblasts
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Ha YC, Cho JJ, Yoo YC, Yang WY
- KMID: 2167972
- Immune Netw.
- 2003 Mar;3(1):61-68.
- doi: 10.4110/in.2003.3.1.61
BACKGROUND: Fibroblast functions both as a structural element and as a vital immunoregulatory cell. Fibroblasts regulate inflammation through governing of chemokine expression. In order to elucidate the mechanisms by which... -
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