- TWIK-Related Spinal Cord K+ Channel Expression Is Increased in the Spinal Dorsal Horn after Spinal Nerve Ligation
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Hwang HY, Zhang E, Park S, Chung W, Lee S, Kim DW, Ko Y, Lee W
- KMID: 2163622
- Yonsei Med J.
- 2015 Sep;56(5):1307-1315.
- doi: 10.3349/ymj.2015.56.5.1307
PURPOSE: The TWIK-related spinal cord K+ channel (TRESK) has recently been discovered and plays an important role in nociceptor excitability in the pain pathway. Because there have been no reports... -
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- The Interaction of Gabapentin and N(6)-(2-phenylisopropyl)-adenosine R-(-)isomer (R-PIA) on Mechanical Allodynia in Rats with a Spinal Nerve Ligation
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Park JY, Jun IG
- KMID: 1785829
- J Korean Med Sci.
- 2008 Aug;23(4):678-684.
- doi: 10.3346/jkms.2008.23.4.678
We examined the antiallodynic interaction between gabapentin and adenosine A1 receptor agonist, N(6)-(2-phenylisopropyl)-adenosine R-(-)isomer (R-PIA), in a rat model of nerve ligation injury. Rats were prepared with ligation of left... -
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- The Effect of Intrathecal Gabapentin on Mechanical and Thermal Hyperalgesia in Neuropathic Rats Induced by Spinal Nerve Ligation
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Cho HS, Kim MH, Choi DH, Lee JI, Gwak MS, Hahm TS
- KMID: 648681
- J Korean Med Sci.
- 2002 Apr;17(2):225-229.
- doi: 10.3346/jkms.2002.17.2.225
Gabapentin decreases the level of glutamate and elevates that of garmma-amino-butyric acid in the central nervous system. Gabapentin was shown to have antinociceptive effects in several facilitated pain models. Intrathecal... -
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- Intrathecal Lamotrigine Attenuates Mechanical Allodynia and Suppresses Microglial and Astrocytic Activation in a Rat Model of Spinal Nerve Ligation
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Choi YS, Jun IG, Kim SH, Park JY
- KMID: 1503892
- Yonsei Med J.
- 2013 Mar;54(2):321-329.
- doi: 10.3349/ymj.2013.54.2.321
PURPOSE: Lamotrigine, a novel anticonvulsant, is a sodium channel blocker that is efficacious in certain forms of neuropathic pain. Recently, microglial and astrocytic activation has been implicated in the development... -
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