- Effect of ezetimibe and simvastatin combination in Korean hypercholesterolemic patients
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Park JH
- KMID: 2252428
- Korean J Med.
- 2005 May;68(5):473-475.
No abstract available. -
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- Effects of simvastatin on the proliferation and apoptosis of human endometrial stromal cells from women with endometriosis
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Moon SH, Lee SE, Kim HG, Choi OH, Lee KS, Na YJ
- KMID: 2273837
- Korean J Obstet Gynecol.
- 2010 Feb;53(2):160-168.
- doi: 10.5468/kjog.2010.53.2.160
OBJECTIVE: To evaluate the effects of simvastatin on the proliferation and apoptosis of human endometrial cells from women with endometriosis. METHODS: Endometrial tissues were obtained from four women with endometriosis. The... -
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- Two Cases of Simvastatin-induced Acute Myopathy
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Kim SM, Oh YM, Sunwoo IN, Park KJ
- KMID: 2342915
- J Korean Neurol Assoc.
- 2001 Jul;19(4):435-437.
Among the side effects of simvastatin, elevated liver enzyme or creatine kinase activity has been occasionally report-ed, but overt myopathy is rare. We report two cases of simvastatin-induced myopathy with... -
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- Effects of Simvastatin on the Expression of VEGF in Human Retinal Pigment Epithelial Cells
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Kim KJ, Kim KS, Kim NR, Chin HS
- KMID: 2338204
- J Korean Ophthalmol Soc.
- 2012 Jun;53(6):849-855.
PURPOSE: To examine the effect of simvastatin on vascular endothelial growth factor (VEGF) expression in cultured human retinal pigment epithelial (RPE) cells under oxidative stress. METHODS: RPE cell viability was measured... -
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- Osteogenic potential of adult stem cells from human maxillary sinus membrane by Simvastatin in vitro: preliminary report
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Yun KI, Kim DJ, Park JU
- KMID: 2471095
- J Korean Assoc Oral Maxillofac Surg.
- 2013 Aug;39(4):150-155.
OBJECTIVES: The objective of this study is to determine the adequate concentration and to evaluate the osteogenic potential of simvastatin in human maxillary sinus membrane-derived stem cells (hSMSC). MATERIALS AND METHODS:... -
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- The Nuclear Orphan Receptor NR4A1 is Involved in the Apoptotic Pathway Induced by LPS and Simvastatin in RAW 264.7 Macrophages
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Kim YC, Song SB, Lee SK, Park SM, Kim YS
- KMID: 2168022
- Immune Netw.
- 2014 Apr;14(2):116-122.
- doi: 10.4110/in.2014.14.2.116
Macrophage death plays a role in several physiological and inflammatory pathologies such as sepsis and arthritis. In our previous work, we showed that simvastatin triggers cell death in LPS-activated RAW... -
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- Simvastatin/Ezetimibe Therapy for Recalcitrant Alopecia Areata: An Open Prospective Study of 14 Patients
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Choi JW, Suh DW, Lew BL, Sim WY
- KMID: 2395184
- Ann Dermatol.
- 2017 Dec;29(6):755-760.
- doi: 10.5021/ad.2017.29.6.755
BACKGROUND: Simvastatin belongs to the statin family, whose members have immunomodulatory activities. Ezetimibe have synergetic effects when co-administered with simvastatin. In several case reports, alopecia totalis and alopecia universalis were... -
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- The Effect of Simvastatin on the Expression of Catalase in Human Retinal Pigment Epithelial Cells
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Kang MG, Lee SY, Chin HS
- KMID: 2216875
- J Korean Ophthalmol Soc.
- 2014 Oct;55(10):1535-1542.
- doi: 10.3341/jkos.2014.55.10.1535
PURPOSE: To evaluate the effects of simvastatin on the catalase expression in human retinal pigment epithelium. METHODS: Retinal pigment epithelial (RPE) cells were incubated for 6 hours and 24 hours with... -
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- Effect of Conventional Dose of Simvastatin on Plaque Regression and Vascular Remodeling in the Peristent Reference Segments of Normocholesterolemic Patients: A Serial Intravascular Ultrasound Assessment
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Hong YJ, Jeong MH, Ahn Y, Moon JY, Kim KH, Park HW, Kim JH, Cho JG, Park JC, Kang JC
- KMID: 2227049
- Korean Circ J.
- 2007 Oct;37(10):483-488.
- doi: 10.4070/kcj.2007.37.10.483
BACKGROUND AND OBJECTIVES: This study aimed to assess the effect of simvastatin therapy on plaque regression and vascular remodeling in peristent reference segments of normocholesterolemic patients by using serial intravascular... -
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- Evaluation of short-term Hypolipidemic Effect and Safety of Simvastatin(Zocor(R)) in Patients with Hyperlipidemia
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Kim MK, Park YH, Park JS, Shin DG, Kim YJ, Kim GS
- KMID: 2049760
- Yeungnam Univ J Med.
- 2003 Dec;20(2):152-159.
- doi: 10.12701/yujm.2003.20.2.152
BACKGROUND: Hyperlipidemia is the one of the major risk factors causing the atherosclerosis of coronary arteries. Treatment of hyperlipidemia with drugs has been confirmed the effects of therapy showing a... -
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- Simvastatin and Losartan Differentially and Synergistically Inhibit Atherosclerosis in Apolipoprotein E-/- Mice
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Lee BS, Choi JY, Kim JY, Han SH, Park JE
- KMID: 2225004
- Korean Circ J.
- 2012 Aug;42(8):543-550.
- doi: 10.4070/kcj.2012.42.8.543
BACKGROUND AND OBJECTIVES: Since statins and angiotensin receptor blockers are a frequently prescribed combination in patients with atherosclerotic cardiovascular diseases, we tested the interactive effects of simvastatin and losartan on... -
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- The Effects of Simvastatin on Bone Healing in Mandible Fractured Rats
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Jeong JO, Kwon YS, Kim SK, Lee KC
- KMID: 2322197
- J Korean Soc Plast Reconstr Surg.
- 2009 Sep;36(5):525-530.
PURPOSE: The hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) are widely used in the treatment of dyslipidemia for lowering of cholesterol level. And the studies in simvastatins have shown to enhance... -
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- Changes of Pulmonary Pathology and Gene Expressions After Simvastatin Treatment in the Monocrotaline-Induced Pulmonary Hypertension Rat Model
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Lee YH, Kim KC, Cho MS, Hong YM
- KMID: 2094104
- Korean Circ J.
- 2011 Sep;41(9):518-527.
- doi: 10.4070/kcj.2011.41.9.518
BACKGROUND AND OBJECTIVES: Simvastatin's properties are suggestive of a potential pathophysiologic role in pulmonary hypertension. The objectives of this study were to investigate changes of pulmonary pathology and gene expressions,... -
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- Screening study for genetic polymorphisms affecting pharmacokinetics of simvastatin
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Im S, Kim BH, Lee K, Kwack K, Yim SV
- KMID: 2383599
- Transl Clin Pharmacol.
- 2016 Mar;24(1):43-54.
- doi: 10.12793/tcp.2016.24.1.43
Simvastatin reduces plasma cholesterol by inhibiting HMG-CoA reductase (HMGR) and is widely used in the treatment of hypercholesterolemia. To screening the possible genetic factors affecting the pharmacokinetics (PK) of simvastatin,... -
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- Effects of the polymorphic MDR1 genotype on the single-dose simvastatin pharmacokinetics in healthy subjects
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Sung JH, Han SS, Lee ME, Ha KS, Kim WJ
- KMID: 2258576
- Korean J Med.
- 2009 Aug;77(2):211-217.
BACKGROUND/AIMS: Simvastatin has dramatically reduced cardiovascular disease due to elevated cholesterol. The human multidrug resistance 1 gene (MDR1) encodes a 170-kDa transmembrane glycoprotein (P-glycoprotein), which plays an important role in... -
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- Methimazole-Induced Acute Cholestatic Hepatitis in a Patient with History of Simvastatin-Induced Liver Injury
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Kwak MK, Kim SR, Park JW, Han SJ, Kim MJ, Jin SY, Kim HJ, Jang JY, Byun DW, Park HK
- KMID: 2317748
- Soonchunhyang Med Sci.
- 2014 Dec;20(2):163-167.
- doi: 10.0000/sms.2014.20.2.163
Methimazole and prophylthiouracil are commonly prescribed for patients with hyperthyroidism. The serious side effect of toxic hepatitis caused by these two drugs is well known. According to recent Korean and... -
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- The safety and efficacy of ezetimibe and simvastatin combination therapy in Korean patients with primary hypercholesterolemia
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Bae JW, Kim HS, Lee SC, Han KH, Jeon ES
- KMID: 2252431
- Korean J Med.
- 2005 May;68(5):487-497.
BACKGROUND: The prevalence of hypercholesterolemia in Korea is growing. In spite of the wide use of HMG-CoA reductase inhibitors (statins), some patients don't reach optimal cholesterol reduction and suffer hepatotoxicity... -
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- Clinical Effects of Simvastatin in Patients with Hypercholesterolemia
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Jeong MH, Cha KS, Park JC, Seo JP, Park JH, Cho JG, Park JG, Suh SP, Park JC, Kang JC
- KMID: 2229056
- Korean Circ J.
- 1997 Apr;27(4):417-425.
- doi: 10.4070/kcj.1997.27.4.417
BACKGROUND: To evaluate the clinical efficacy of Simvastatin, a HMG-CoA reductase inhibitor, We ibsweved the changes of clinical characteristics and lipid profiles after Simvastatin administration in patients with hypercholesterolemia. METHODS... -
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- Simvastatin as a Modulator of Tissue Remodeling through Inhibition of Matrix Metalloproteinase (MMP) Release from Human Lung Fibroblasts
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Ra JE, Lee JK, Kim HJ
- KMID: 2319550
- Tuberc Respir Dis.
- 2011 Sep;71(3):172-179.
BACKGROUND: Statins can regulate the production of pro-inflammatory cytokines and inhibit MMP production or activation in a variety of types of cells. This study evaluated whether statins would inhibit MMP... -
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- Synergistic Effect of Sulindac and Simvastatin on Apoptosis in Lung Cancer A549 Cells through AKT-Dependent Downregulation of Survivin
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Kim YS, Seol CH, Jung JW, Oh SJ, Hwang KE, Kim HJ, Jeong ET, Kim HR
- KMID: 2380394
- Cancer Res Treat.
- 2015 Jan;47(1):90-100.
- doi: 10.4143/crt.2013.194
PURPOSE: Non-steroidal anti-inflammatory drugs (NSAIDs) and statins are potential chemopreventive or chemotherapeutic agents. The mechanism underlying the deregulation of survivin by NSAIDs and statins in human non-small cell lung cancer... -
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