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Comparative Analysis of Phospholipase D2 Localization in the Pancreatic Islet of Rat and Guinea Pig

Ryu GR, Kim MJ, Song CH, Min DS, Rhie DJ, Yoon SH, Hahn SJ, Kim MS, Jo YH

  • KMID: 2285289
  • Korean J Physiol Pharmacol.
  • 2003 Aug;7(4):211-216.
To examine the localization pattern of phospholipase D2 (PLD2) in the pancreatic islet (the islet of Langerhans) depending on species, we conducted a morphological experiment in the rat and guinea...
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Hypoxia Increases β-Cell Death by Activating Pancreatic Stellate Cells within the Islet

Kim JJ, Lee E, Ryu GR, Ko SH, Ahn YB, Song KH

Background Hypoxia can occur in pancreatic islets in type 2 diabetes mellitus. Pancreatic stellate cells (PSCs) are activated during hypoxia. Here we aimed to investigate whether PSCs within the islet are...
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Altered Secretory Pattern of Pancreatic Enzymes and Gastrointestinal Hormones in Streptozotocin-induced Diabetic Rats

Kim MJ, Ryu GR, Yi SY, Min DS, Rhie DJ, Yoon SH, Hahn SJ, Kim MS, Jo YH

  • KMID: 1615198
  • Korean J Physiol Pharmacol.
  • 2002 Dec;6(6):311-317.
This study was performed to investigate the pancreatic exocrine dysfunction in streptozotocin- induced diabetic rats. Changes in pancreatic enzymes secretion and in pancreatic enzymes content were observed. The output and...
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Decreased Expression and Induced Nucleocytoplasmic Translocation of Pancreatic and Duodenal Homeobox 1 in INS-1 Cells Exposed to High Glucose and Palmitate

Ryu GR, Yoo JM, Lee E, Ko SH, Ahn YB, Song KH

BACKGROUND: Type 2 diabetes mellitus (T2DM) is often accompanied by increased levels of circulating fatty acid. Elevations in fatty acids and glucose for prolonged periods of time have been suggested...
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Electrophysiological and Morphological Classification of Inhibitory Interneurons in Layer II/III of the Rat Visual Cortex

Rhie DJ, Kang HY, Ryu GR, Kim MJ, Yoon SH, Hahn SJ, Min DS, Jo YH, Kim MS

  • KMID: 1607516
  • Korean J Physiol Pharmacol.
  • 2003 Dec;7(6):317-323.
Interneuron diversity is one of the key factors to hinder understanding the mechanism of cortical neural network functions even with their important roles. We characterized inhibitory interneurons in layer II/III...
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Altered Cholecystokinin-induced Calcium Signal in Streptozotocin-induced Diabetic Rat Pancreatic Acini

Kim MJ, Ryu GR, Sung JH, Min DS, Rhie DJ, Yoon SH, Hahn SJ, Jo YH, Kim MS

  • KMID: 1066043
  • Korean J Gastroenterol.
  • 2003 Dec;42(6):519-526.
BACKGROUND/AIMS: Pancreatic acini of streptozotocin (STZ)-induced diabetic rats release amylase less than normal acini on cholecystokinin (CCK) stimulation. Pancreatic enzyme secretion has been closely related to the intracellular calcium...
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Protective Effect of Heme Oxygenase-1 on High Glucose-Induced Pancreatic beta-Cell Injury

Lee EM, Lee YE, Lee E, Ryu GR, Ko SH, Moon SD, Song KH, Ahn YB

BACKGROUND: Glucose toxicity that is caused by chronic exposure to a high glucose concentration leads to islet dysfunction and induces apoptosis in pancreatic beta-cells. Heme oxygenase-1 (HO-1) has been identified...
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The Role of cAMP/PKA Activation on Exendin-4-Induced Cyclin D1 Expression in INS-1 Cell

Ryu GR, Kang JH, Jang HI, Ko SH, Jeong IK, Rhie DJ, Yoon SH, Hahn SJ, Jo YH, Kim MS, Kim MJ

  • KMID: 2177757
  • J Korean Diabetes Assoc.
  • 2005 Jul;29(4):295-303.
BACKGROUND: Glucagon-like peptide-1(GLP-1) and exendin-4(EX-4) have been known to induce pancreatic islet proliferation and increases in the betacell mass. Cyclin D1 is a key protein responsible for the entry of...
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Immunocytochemical Study on the Change of the Activated T Cells in Peripheral Blood of the Pulmonary Tuberculosis Patients

Ryu GR, Park CH, Park US, Jeoung PJ, Hwang YS, Lee YJ, Chang GY

  • KMID: 2317950
  • Tuberc Respir Dis.
  • 1995 Dec;42(6):823-830.
BACKGROUND: It has been found that Helper T cells in the peripheral blood are decreased in the cell mediated immunity in the pulmonary tuberculosis But it has not been confirmed...
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Transdifferentiation of Enteroendocrine K-cells into Insulin-expressing Cells

Lee E, Yu JM, Lee MK, Ryu GR, Ko SH, Ahn YB, Moon SD, Song KH

BACKGROUND: Despite a recent breakthough in human islet transplantation for treating type 1 diabetes mellitus, the limited availability of donor pancreases remains a major obstacle. Endocrine cells within the gut...
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The Inhibitory Effect of Epicatechin on IL-1beta -induced iNOS Expression and NO Production in RINm5F Cell

Ryu GR, Min DS, Rhie DJ, Yoon SH, Hahn SJ, Kim MS, Jo YH, Kim MJ

  • KMID: 2008132
  • J Korean Diabetes Assoc.
  • 2003 Dec;27(6):456-466.
BACKGROUND: Interleukin-1beta (IL-1beta ) stimulates the expression of inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO), lead to NO-mediated insulin, which produces cell damage. Within...
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The Effect of Epicatechin on the High Glucose-induced TSP-1 Expression and MMP-2 Activity in Rat Vascular Smooth Muscle Cells

Ryu GR, Kang JH, Hong KJ, Jeong IK, Jang HI, Rhie DJ, Yoon SH, Hahn SJ, Kim MS, Jo YH, Kim MJ

BACKGROUND: The incidence of atherosclerosis is well correlated with the progression of type 2 diabetes mellitus. High plasma glucose in uncontrolled diabetic patients evokes many vascular complications such as atherosclerosis....
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Differentiation of Pancreatic beta Cells from Human Pancreatic Duct Cells Derived from a Partial Pancreas Tissue

Song KH, Kim MM, Lee MK, Ryu GR, Ko SH, Moon SD, Ahn YB, Yoon KH, Cha BY, Lee KW, Son HY, Kang SK, Chin HM

BACKGROUND: Despite a recent breakthrough in human islet transplantation for treating diabetes mellitus, the limited availability of insulin-producing tissue is still a major obstacle. This has led to a search...
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