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The role of H1- and H2-receptors in the effect of compound 48/80 in the asphyxiation and body temperature of mice

Ulugol A, Karadag H, Dokmeci D, Dokmeci I

Contribution of histamine H1- and H2-receptors to the effect of compound 48/80, a potent histamine releaser, upon asphyxiation and body temperature in mice was investigated in the present experiments. Compound...
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Block of hERG K+ Channel by Classic Histamine H1 Receptor Antagonist Chlorpheniramine

Hong HK, Jo SH

Chlorpheniramine is a potent first-generation histamine H1 receptor antagonist that can increase action potential duration and induce QT prolongation in several animal models. Since block of cardiac human ether-a-go-go-related gene...
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Olopatadine ophthalmic solution suppresses substance P release in the conjunctivitis models

Tamura T

BACKGROUND: Olopatadine hydrochloride ophthalmic solutions are treated for allergic conjunctival diseases that are a selective histamine H1 receptor antagonist and an inhibitor of the release of mediators including histamine from...
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Effects of Antidepressants on Sleep

Kim GH, Yang CK

  • KMID: 2287190
  • Korean J Psychopharmacol.
  • 2006 Jul;17(4):325-334.
The diverse effects of antidepressants on sleep are mediated by their agonistic or antagonistic properties on specific neurotransmitters: the catecholamine, serotonergic, cholinergic, and histaminergic neurotransmitter systems, which also regulate the...
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Investigation of the antiallergic activity of olopatadine on rhinitis induced by intranasal instillation of antigen in sensitized rats using thermography

Tamura T

BACKGROUND: The main symptoms of allergic rhinitis (AR) are sneezing, rhinorrhea and nasal obstruction. It was reported that the nasal skin temperature after intranasal administration of histamine or grass pollen...
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