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Induction of c-Jun mRNA without changes of estrogen and progesterone receptor expression in myometrium during human labor

Roh CR, Lee BL, Oh WJ, Whang JD, Choi DS, Yoon BK, Lee JH

To elucidate the endocrine mechanism of human parturition, the expression of c-Jun and c-Fos mRNA were examined in relation to estrogen receptor (ER) and progesterone receptor (PR) in human myometrium....
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Clinicopathlogic and Immunohistochemical Characteristics of Triple Negative Invasive Lobular Carcinoma

Koo JS, Jung W

PURPOSE: Our study is performed to find out clinicopathlogic and immunohistochemical (IHC) characteristics of triple negative invasive lobular carcinoma (ILC), as has been demonstrated in their invasive ductal counterparts. MATERIALS...
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Heterogeneity of Invasive Ductal Carcinoma: Proposal for a Hypothetical Classification

Jo BH, Chun YK

To investigate what heterogeneity exists in breast cancer, 228 consecutive patients with operable invasive duetal carcinoma (IDC), not otherwise specified, were categorized on the basis of the horizontal progression model...
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Effects of cyclosporin A on sex hormone and estrogen receptor in male rat with special reference to cyclosporin A-induced osteoporosis

Shin WY, Li SZ, Chung SS, Lee HC, Huh KB, Lim SK

The mechanisms of high turnover bone loss induced by Cyclosporin A (CsA) are not clearly understood. Deficiencies in sex hormones result in high turnover osteoporosis, and not only androgen but...
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Immunophenotypes of Glycogen Rich Clear Cell Carcinoma

Kim SE, Koo JS, Jung WH

PURPOSE: Glycogen rich clear cell carcinoma (GRCC) of the breast is a rare subtype of invasive ductal carcinoma and involves a poor prognosis. In the literature, less than 150 cases...
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Sonography of Invasive Apocrine Carcinoma of the Breast in Five Cases

Seo KJ, An YY, Whang IY, Chang ED, Kang BJ, Kim SH, Park CS, Kim JS, Hong H

OBJECTIVE: To evaluate the sonographic features of invasive apocrine carcinoma (IAC) of the breast. MATERIALS AND METHODS: This study included five pathologically proven cases of IAC, and their sonographic features were...
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Correlations of bcl-2 expression with clinicopathological features in breast cancer

Lee HD, Koo JY, Jung WH

To evaluate the prognostic significance of bcl-2, we investigated the correlation of bcl-2 expression with the established indicators of prognosis and tumor behavior in breast cancer. This study included a...
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Clinicopathological Significance of Maspin Expression in Breast Cancer

Lee MJ, Suh CH, Li ZH

Maspin is a unique serine proteinase inhibitor that has tumor suppressor activity. It has been reported that maspin is expressed in normal human mammary epithelial cells and it is down-regulated...
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Is There a Correlation between the Presence of a Spiculated Mass on Mammogram and Luminal A Subtype Breast Cancer?

Liu S, Wu XD, Xu WJ, Lin Q, Liu XJ, Li Y

OBJECTIVE: To determine whether the appearance of a spiculated mass on a mammogram is associated with luminal A subtype breast cancer and the factors that may influence the presence or...
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The Role of Microsatellite Instability at Chromosome 11p15.5 in the Progression of Breast Ductal Carcinoma

Kim DJ, Park JY, Lee MH, Sohn YK

The study of microsatellite instability (MSI) has provided the evidence to support asequential, progressive pathway for the development of cancer. In this study, we analyzed the role of MSI at...
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Conservative therapy with metformin plus megestrol acetate for endometrial atypical hyperplasia

Shan W, Wang C, Zhang Z, Gu C, Ning C, Luo X, Zhou Q, Chen X

OBJECTIVE: To compare the efficacy of metformin plus megestrol acetate (MA) with that of MA alone for treating endometrial atypical hyperplasia (EAH). METHODS: This pilot study included 16 EAH patients who...
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Prognostic Value of p53 and bcl-2 Expression in Patients Treated with Breast Conservative Therapy

Kim K, Chie EK, Han W, Noh DY, Park IA, Oh DY, Im SA, Kim TY, Bang YJ, Ha SW

Prognostic value of p53 and bcl-2 expression on treatment outcome in breast cancer patients has been extensively evaluated, but the results were inconclusive. We evaluated the prognostic significance of these...
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Estrogen receptor independent neurotoxic mechanism of bisphenol A, an environmental estrogen

Lee YM, Seong MJ, Lee JW, Lee YK, Kim TM, Nam SY, Kim DJ, Yun YW, Kim TS, Han SY, Hong JT

Bisphenol A (BPA), a ubiquitous environmental contaminant, has been shown to cause developmental toxicity and carcinogenic effects. BPA may have physiological activity through estrogen receptor (ER) -alpha and -beta, which...
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A Case of Breast Cancer in a Male Patient with Cryptogenic Cirrhosis

Shin SR, Lee MS, Park SH, Choi JS, Lee KM, Kim JB, Kim HS, Kim JW

Breast cancer is a rare disease in men. We report a case of 53-year-old obese male, with known cryptogenic cirrhosis and hepatocellular carcinoma, presenting a tender mass on left breast....
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