- The Effects of Insulin-like Growth Factor-I (IGF-I) in Mouse Lung Cancer Cells
-
Kwak SM, Kim SK, Kim SK, Cho CH
- KMID: 1972954
- Cancer Res Treat.
- 2002 Apr;34(2):122-127.
PURPOSE: Insulin-like growth factor-I (IGF-I) is an important mitogen in many types of malignancies. The purpose of this study was to evaluate the role of the IGF system on cell... -
- CITED
-
- Close
- SHARE
-
- Close
- A case of acromegaly with mixed papillary-follicular thyroid carcinoma
-
Lee CH, Cheon NI, Hong SI, Chung JO, Yoon IS, Cho DH, Kang HC, Chung DJ, Chung MY
- KMID: 1927518
- Korean J Med.
- 2002 Mar;62(3):307-312.
Patients with acromegaly have high incidence of benign or malignant neoplasia than general population and many investigators suggest the stimulatory effect of GH and IGF-1 on mesenchymal cells. Both normal... -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of Insulin-Like Growth Factor-1 on Proliferation of Human Corpus Cavernosal Smooth Muscle Cells
-
Kim MK, Park K, Lee HS, Ahn K, Lee HC
- KMID: 2145844
- Korean J Androl.
- 2003 Apr;21(1):18-22.
PURPOSE: Insulin-like growth factor-1 (IGF-1) promotes the proliferation and migration of penile cavernous smooth muscle cells in the rat. The goals of this study were to evaluate the expression of... -
- CITED
-
- Close
- SHARE
-
- Close
- Correlation between Expression of Insulin-like Growth Factor-I Receptor and Clinicopathologic Prognostic Factors in Invasive Ductal Carcinoma of the Breast
-
Oh SY, Kang MJ, Moon WS, Choi HY
- KMID: 2173559
- J Korean Breast Cancer Soc.
- 2002 Jun;5(2):118-124.
- doi: 10.4048/jkbcs.2002.5.2.118
PURPOSE: The insulin-like growth factor-I receptor (IGF-IR) is a member of the transmembrane tyrosine kinase family that regulates various biological processes. These processes include maintaining optimal cell growth, establishing and... -
- CITED
-
- Close
- SHARE
-
- Close
- A Case of Non-islet Cell Tumor Hypoglycemia
-
Chae YT, Hwang IJ, Ryu KH, Ko EH, Rue JI, Kim SK, Park SW, Kim YR, Cho YW, Choi YK, Lee SJ
- KMID: 2200670
- J Korean Soc Endocrinol.
- 2006 Feb;21(1):74-78.
- doi: 10.3803/jkes.2006.21.1.74
Mesenchymal tumors including hemangiopericytomas, hepatocellular tumors, adrenal carcinomas, and a variety of other large tumors have been reported to produce excessive amounts of insulin-like growth factor (IGF) type II precursor,... -
- CITED
-
- Close
- SHARE
-
- Close
- Correlation between Expression of Insulin-like Growth Factor-I Receptor and Clinicopathologic Prognostic Factors in Invasive Ductal Carcinoma of the Breast
-
Oh SY, Kang MJ, Moon WS, Choi HY
- KMID: 2324977
- J Korean Surg Soc.
- 2002 May;62(5):396-402.
PURPOSE: The insulin-like growth factor-I receptor (IGF-IR) is a member of the transmembrane tyrosine kinase family that regulates various biological processes. These processes include maintaining optimal cell growth, establishing and... -
- CITED
-
- Close
- SHARE
-
- Close
- The effect of Insulin like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) on cellular proliferation in mouse 3T3 fibroblast cells
-
Cho CH, Kwak SM, Moon TH, Cho JH, Ryu JS, Lee HL
- KMID: 2318244
- Tuberc Respir Dis.
- 1999 Nov;47(5):618-628.
BACKGROUND: Cell growth is a balance between cell proliferation and cell death. Insulin-like growth factor-I(IGF-I), which binds IGF-I receptor (IGF-IR), mediates cellular proliferation as a potent mitogen. IGF binding protein-3... -
- CITED
-
- Close
- SHARE
-
- Close
- Anticarcinogenic effect of quercetin by inhibition of insulin-like growth factor (IGF)-1 signaling in mouse skin cancer
-
Jung M, Bu SY, Tak KH, Park JE, Kim E
- KMID: 2313692
- Nutr Res Pract.
- 2013 Dec;7(6):439-445.
It has been shown that dysregulation of IGF-1 signaling is associated with tumor incidence and progression, whereas blockade of the signaling can effectively inhibit carcinogenesis. Although several mechanisms of anticancer... -
- CITED
-
- Close
- SHARE
-
- Close
- Mitogenic effects of nicotine to human periodontal ligament(PDL) cells in vitro
-
Row J, Chun YS
- KMID: 2271780
- Korean J Orthod.
- 1997 Dec;27(6):955-961.
Nicotine is one of the major components of cigafette smoking which causes various systemic and local diseases to human body. Mitrogenic effects of nicotine to systemic disease are interesting factors... -
- CITED
-
- Close
- SHARE
-
- Close
- Klotho plays a critical role in clear cell renal cell carcinoma progression and clinical outcome
-
Kim JH, Hwang KH, Lkhagvadorj S, Jung JH, Chung HC, Park KS, Kong ID, Eom M, Cha SK
- KMID: 2285602
- Korean J Physiol Pharmacol.
- 2016 May;20(3):297-304.
- doi: 10.4196/kjpp.2016.20.3.297
Klotho functions as a tumor suppressor predominantly expressed in renal tubular cells, the origin of clear cell renal cell carcinoma (ccRCC). Altered expression and/or activity of growth factor receptor have... -
- CITED
-
- Close
- SHARE
-
- Close
- Two Cases of Growth Hormone Therapy in Idiopathic Dilated Cardiomyopathy
-
Shin JW, Kil HR, Yu JH
- KMID: 2207425
- J Korean Pediatr Soc.
- 2001 Aug;44(8):942-947.
Growth hormone receptor gene is expressed in the myocardium and growth hormone(GH) administration has been shown to increase cardiac insulin-like growth factor-I(IGF-1) contents. The cardiac myocyte express IGF-I receptors and... -
- CITED
-
- Close
- SHARE
-
- Close
- Clinical significance of insulin-like growth factor-1 receptor expression in stage I non-small-cell lung cancer: immunohistochemical analysis
-
Lee CY, Jeon JH, Kim HJ, Shin DH, Roh TW, Ahn CM, Chang YS
- KMID: 759967
- Korean J Intern Med.
- 2008 Sep;23(3):116-120.
- doi: 10.3904/kjim.2008.23.3.116
BACKGROUND/AIMS: The insulin-like growth factor (IGF) system has been implicated in tumor growth, invasion, and metastasis. However, reports on the IGF-1 receptor (IGF-1R) based on radioimmunoassays are conflicting, and... -
- CITED
-
- Close
- SHARE
-
- Close
- Simvastatin Induces Apoptosis and Suppresses Insulin-Like Growth Factor 1 Receptor in Bile Duct Cancer Cells
-
Lee J, Hong EM, Jang JA, Park SW, Koh DH, Choi MH, Jang HJ, Kae SH
- KMID: 2363978
- Gut Liver.
- 2016 Mar;10(2):310-317.
- doi: 10.5009/gnl15195
BACKGROUND/AIMS: Statins act as antineoplastic agents through the inhibition of cell proliferation. This study sought to demonstrate the effects of statins on extrahepatic bile duct cancer cell apoptosis and to... -
- CITED
-
- Close
- SHARE
-
- Close
- Insulin-like Growth Factor-1 Receptor Dictates Beneficial Effects of Treadmill Training by Regulating Survival and Migration of Neural Stem Cell Grafts in the Injured Spinal Cord
-
Hwang DH, Park HH, Shin HY, Cui Y, Kim BG
- KMID: 2430107
- Exp Neurobiol.
- 2018 Dec;27(6):489-507.
- doi: 10.5607/en.2018.27.6.489
Survival and migration of transplanted neural stem cells (NSCs) are prerequisites for therapeutic benefits in spinal cord injury. We have shown that survival of NSC grafts declines after transplantation into... -
- CITED
-
- Close
- SHARE
-
- Close
- Differential Expression of Neuronal Death-related Factors in Aged Rat Cerebellum
-
Park BJ, Chung YH, Kim SS, Kim KY, Lee WB
- KMID: 2376075
- Korean J Phys Anthropol.
- 2007 Jun;20(2):145-155.
In the present study, we investigated the expression of apoptosis-associated proteins in the cerebellum of aged rats: IGF-I receptor (IGF-IR), nitrotyrosine (NT), p53, key pro-apoptotic gene ICH-1 (caspase-2), c-Fos and... -
- CITED
-
- Close
- SHARE
-
- Close
- Malignant solitary fibrous tumor of the pleura causing recurrent hypoglycemia; immunohistochemical stain of insulin-like growth factor i receptor in three cases
-
Chang ED, Lee EH, Won YS, Kim JM, Suh KS, Kim BK
- KMID: 648261
- J Korean Med Sci.
- 2001 Apr;16(2):220-224.
- doi: 10.3346/jkms.2001.16.2.220
We present three cases of malignant solitary fibrous tumors of the pleura (SFTP) that produced recurrent hypoglycemia. Removal of the tumors produced normoglycemia. The tumors were well circumscribed and lobulated,... -
- CITED
-
- Close
- SHARE
-
- Close
- Growth Hormone-Releaser Diet Attenuates Cognitive Dysfunction in Klotho Mutant Mice via Insulin-Like Growth Factor-1 Receptor Activation in a Genetic Aging Model
-
Park SJ, Chung YH, Lee JH, Dang DK, Nam Y, Jeong JH, Kim YS, Nabeshima , Shin EJ, Kim HC
- KMID: 2169471
- Endocrinol Metab.
- 2014 Sep;29(3):336-348.
- doi: 10.3803/EnM.2014.29.3.336
BACKGROUND: It has been recognized that a defect in klotho gene expression accelerates the degeneration of multiple age-sensitive traits. Accumulating evidence indicates that aging is associated with declines in cognitive... -
- CITED
-
- Close
- SHARE
-
- Close
- PTEN/MMAC1 enhances the growth inhibition by anticancer drugs with downregulation of IGF-II expression in gastric cancer cells
-
Hwang PH, Kim SY, Lee JC, Kim SJ, Yi HK, Lee DY
- KMID: 1089448
- Exp Mol Med.
- 2005 Oct;37(5):391-398.
PTEN/MMAC1 is a tumor suppressor gene that is mutated in a variety of advanced and metastatic cancers. Its major function is likely to be the phosphatase activity that regulates the... -
- CITED
-
- Close
- SHARE
-
- Close
- Prognostic Significance of p53, mTOR, c-Met, IGF-1R, and HSP70 Overexpression after the Resection of Hepatocellular Carcinoma
-
Kang GH, Lee BS, Lee ES, Kim SH, Lee HY, Kang DY
- KMID: 1774532
- Gut Liver.
- 2014 Jan;8(1):79-87.
BACKGROUND/AIMS: The current study examines the expression of molecular biomarkers in hepatocellular carcinoma (HCC) and whether these findings correlate with the clinicopathologic features of the disease and patient survival. METHODS: We... -
- CITED
-
- Close
- SHARE
-
- Close
- Gene Expression Profiles of Uterine Normal Myometrium and Leiomyoma and Their Estrogen Responsiveness In Vitro
-
Lee EJ, Bajracharya P, Lee DM, Cho KH, Kim KJ, Bae YK, Kim MJ, Lee KH, Kim HJ, Song GH, Chun SS, Choi I
- KMID: 1837531
- Korean J Pathol.
- 2010 Jun;44(3):272-283.
BACKGROUND: Uterine leiomyomas are common benign smooth muscle tumors among the reproductive aged-women. The research has been aimed to identify the differentially expressed genes between normal myometrium and leiomyoma and... -
- CITED
-
- Close
- SHARE
-
- Close
