- Two-Week Repeated Dose Toxicity of Atractylodis Rhizoma Alba in F344 Rats
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Han HY, Yang YS, Kim SN, Han SC, Lee JH, Jeong JY, Roh HS, Seok JH, Lee JS, Kim JA, Min BS
- KMID: 2355143
- Nat Prod Sci.
- 2016 Sep;22(3):180-186.
- doi: 10.20307/nps.2016.22.3.180
This research is to estimate the toxicity of Atractylodis Rhizoma Alba (ARA) in F344 rats and to find a dose level for the 13 weeks toxicity study. A hot water... -
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- Effects of a soluble dietary fibre NUTRIOSE(R) on colonic fermentation and excretion rates in rats
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Guerin-Deremaux L, Ringard F, Desailly F, Wils D
- KMID: 2313482
- Nutr Res Pract.
- 2010 Dec;4(6):470-476.
The resistant dextrin NUTRIOSE(R), developed from starch, is expected to act as a prebiotic. The aim of this study was to determine the effects of NUTRIOSE(R) on cecal parameters, short-chain... -
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- The Enhancing Effect of Ethanol on the Development of Glutatione S-Transferase Placental Form-Positive Foci Induced by Diethylnitrosamine in F344 Rat
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Cho KJ, Myung NH, Jang JJ
- KMID: 1421473
- J Korean Med Sci.
- 1990 Mar;5(1):13-17.
- doi: 10.3346/jkms.1990.5.1.13
The effects of ethyl alcohol and pig serum administration on the development of preneoplastic hepatic enzyme-altered foci were examined in an in vivo mid-term assay system. Rats were initially given... -
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- Modifying Effect of Indole-3-carbinol on the Rat Colon Carcinogenesis
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Jo H, Han BS, Kang JS, Jang DD, Kim K, Ahn B, Kim DJ
- KMID: 2114701
- Lab Anim Res.
- 2010 Dec;26(4):339-343.
- doi: 10.5625/lar.2010.26.4.339
Indole-3-carbinol (I3C) found in various cruciferous vegetables has been shown to exert anti-carcinogenic activity in several target organs. Our study was conducted to assess the modifying effect of I3C on... -
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- Effect of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor on the Goblet Cell Production in Ovalbumin-sensitized Rats
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Lee HM, Hwang SJ, Lee SH
- KMID: 2074239
- Korean J Otolaryngol-Head Neck Surg.
- 2001 Apr;44(4):376-380.
BACKGROUND AND OBJECTIVES: Hypertrophic and metaplastic changes of goblet cells associated with mucus hypersecretion are common characteristics of airway inflammation. The purposes of this study were to observe goblet cell... -
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- A 14-Day Repeated Dose Toxicity of Epimedii Herba Aqueous Extract Administered by Oral Gavage in F344 Rats
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Han HY, Yang YS, Kim SN, Han SC, Han KH, Lee JH, Jeong JY, Roh HS, Seok JH, Kim JA, Min BS
- KMID: 2409597
- Nat Prod Sci.
- 2015 Mar;21(1):34-41.
- doi: 10.0000/nps.2015.21.1.34
The objective of this study is to characterize a toxicity of Epimedii Herba (EH) in F344 rats and to find a dose levels for the 13 weeks toxicity study. EH... -
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- Colon Cancer Chemoprevention With Ginseng and Other Botanicals
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Wargovich
- KMID: 1721180
- J Korean Med Sci.
- 2001 Dec;16(Suppl):S81-S86.
- doi: 10.3346/jkms.2001.16.S.S81
Colorectal cancer is becoming increasingly common in Asian countries and still remains the second leading cause of cancer deaths in the United States. Efforts to prevent colon cancer have targeted... -
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- Impact of Long-Term Proton Pump Inhibitor Therapy on Gut Microbiota in F344 Rats: Pilot Study
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Shin CM, Kim N, Kim YS, Nam RH, Park JH, Lee DH, Seok YJ, Kim YR, Kim JH, Kim JM, Kim JS, Jung HC
- KMID: 2412094
- Gut Liver.
- 2016 Nov;10(6):896-901.
- doi: 10.5009/gnl15529
BACKGROUND/AIMS: To evaluate changes in gut microbiota composition following long-term proton pump inhibitor (PPI) treatment. METHODS: Twenty-four-week-old F344 rats were fed diets with (n=6) or without (n=5) lansoprazole for 50 weeks.... -
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- Impaired DNA Synthesis by Copper Cytotoxicity in LEC Mutant Rat
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Kim JK, Kwon YM, Oh JM
- KMID: 2092853
- Korean J Anat.
- 2004 Dec;37(6):565-570.
Long-Evans Cinnamon (LEC) mutant rat, which spontaneously develops a necrotizing hepatic injury at 4 ~5 months of age, reveals an excess hepatic copper accumulation and is a good model for... -
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- A Single Intraperitoneal Injection of Endotoxin Changes Glial Cells in Rats as Revealed by Positron Emission Tomography Using [¹¹C]PK11195
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Ota M, Ogura J, Ogawa S, Kato K, Matsuda H, Kunugi H
- KMID: 2414813
- Nucl Med Mol Imaging.
- 2018 Jun;52(3):224-228.
- doi: 10.1007/s13139-017-0510-9
PURPOSE: Intracranial administration of lipopolysaccharide (LPS) is known to elicit a rapid innate immune response, activate glial cells in the brain, and induce depression-like behavior. However, no study has focused... -
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- Comparison of Changes in the Interstitial Cells of Cajal and Neuronal Nitric Oxide Synthase-positive Neuronal Cells With Aging Between the Ascending and Descending Colon of F344 Rats
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Lee SM, Kim N, Jo HJ, Park JH, Nam RH, Lee HS, Kim HJ, Lee MY, Kim YS, Lee DH
- KMID: 2395429
- J Neurogastroenterol Motil.
- 2017 Oct;23(4):592-605.
- doi: 10.5056/jnm17061
BACKGROUND/AIMS: Neuronal degeneration and changes in interstitial cells of Cajal (ICCs) are important mechanisms of age-related constipation. This study aims to compare the distribution of ICCs and neuronal nitric oxide... -
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- The Effect of Cochinchina momordica Seed Extract on Gastric Acid Secretion and Morphologic Change in Aged Rat Stomach
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Jo HJ, Kim N, Nam RH, Chang H, Kim JH, Park JH, Kang JM, Lee DH, Jung HC
- KMID: 1806673
- Gut Liver.
- 2013 Sep;7(5):560-568.
BACKGROUND/AIMS: Cochinchina momordica seed extract (SK-MS10) has a gastric protective effect. We aimed to assess the effect of SK-MS10 on gastric acid secretion with morphologic changes in the aged rat. METHODS:... -
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- Partial cross-resistance between Strongyloides venezuelensis and Nippostrongylus brasiliensis in rats
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Baek BK, Islam MK, Kim JH, Lee JW, Hur J
- KMID: 1715272
- Korean J Parasitol.
- 1999 Jun;37(2):101-107.
- doi: 10.3347/kjp.1999.37.2.101
Rats were immunized through an initial infection with 1,000 filariform larvae (L3) of Nippostrongylus brasiliensis and after complete expulsion of worms they were challenged with 1,000 L3 of Strongyloides venezuelensis... -
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- Inhibition by Ginseng of Colon Carcinogenesis in Rats
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Fukushima , Wanibuchi , Li W
- KMID: 1721179
- J Korean Med Sci.
- 2001 Dec;16(Suppl):S75-S80.
- doi: 10.3346/jkms.2001.16.S.S75
The inhibitory effects of ginseng on the development of 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) in the colon were investigated in rats. Male, 6-week-old rats were injected with DMH once... -
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- Different modifying responses of capsaicin in a wide-spectrum initiation model of F344 rat
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Jang JJ, Cho KJ, Lee YS, Bae JH
- KMID: 1421512
- J Korean Med Sci.
- 1991 Mar;6(1):31-36.
- doi: 10.3346/jkms.1991.6.1.31
The modifying potential of capsaicin (CAP) on lesion development was examined in a rat multiorgan carcinogenesis model. Groups 1 and 2 were treated sequentially with diethylnitrosamine (DEN) (100 mg/kg, ip,... -
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- Effects of in vitro culture methods on morphological development and infectivity of Strongyloides venezuelensis filariform larvae
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Islam MK, Matsuda K, Kim JH, Baek BK
- KMID: 1715278
- Korean J Parasitol.
- 1999 Mar;37(1):13-19.
- doi: 10.3347/kjp.1999.37.1.13
The effects of in vitro culture methods on morphological development and infectivity of Strongyloides venezuelensis filariform larvae (L3) to rats were investigated. A significantly higher body length was observed... -
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- PCR in diagnosis of pneumocystosis of rats
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Hong ST
- KMID: 1715355
- Korean J Parasitol.
- 1996 Sep;34(3):191-196.
- doi: 10.3347/kjp.1996.34.3.191
Polymerase chain reaction (PCR) is a powerful technique to detect scanty amount of DNA from living organisms. The present study intended to develop specific primers for PCR diagnosis of pneumocystosis... -
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- Protective Effect of Urinary Alkalinization on Gentamicin Nephrotoxicity in Rats
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Lee HY, Choi KH, Bank N
- KMID: 1729551
- Yonsei Med J.
- 1988 Sep;29(3):225-232.
- doi: 10.3349/ymj.1988.29.3.225
We investigated the effect of urinary alkalinization accomplished by intraperitoneal injection of sodium bicarbonate and acetazolamide on gentamicin nephrotoxicity in male Fisher 344rats. Forty rats (body weight 200-300g) were... -
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- Root Resorption in Streptozotocin-induced Diabetic Rats with Ligature-induced Periodontitis
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Kim JH, Lee DE, Park JC, Kim YJ, Cha JH, Bak EJ, Yoo YJ
- KMID: 2068540
- Int J Oral Biol.
- 2015 Sep;40(3):111-116.
- doi: 10.11620/IJOB.2015.40.3.111
To determine the effect of diabetes on root resorption in periodontitis, we investigated odontoclast formation and root resorption in diabetic rats with periodontitis. Odontoclast formation was observed in three groups... -
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- Nip2 Expression of Postnatal, Aged and Transient Focal Cerebral Ischemic Rat
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Kim YT, Lee WK, Lee YI, Lee JG, Park HC, Jin KS
- KMID: 2092801
- Korean J Anat.
- 2002 Dec;35(6):543-550.
Nip2 mRNA expression of hippocampus was clarified in the postnatal, adult and aging rat. We observed the change of Nip2 mRNA expression in the ischemic rat hippocampus at 3, 6,... -
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