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Examining the Gm18 and m1G Modification Positions in tRNA Sequences

Subramanian M, Srinivasan T, Sudarsanam D

The tRNA structure contains conserved modifications that are responsible for its stability and are involved in the initiation and accuracy of the translation process. tRNA modification enzymes are prevalent in...
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Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases

Fu Y, Lee I, Lee YS, Bao X

tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs...
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RNA Granules and Stress Granules in Virus Systems

Kim K

Viruses initiate a number of cellular stress responses and modulate gene regulation and compartmentalization of RNA upon infection to be successful parasites. Virus infections may induce or impair stress granule...
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Complete Mitochondrial Genome of Echinostoma hortense (Digenea: Echinostomatidae)

Liu ZX, Zhang Y, Liu YT, Chang QC, Su X, Fu X, Yue DM, Gao Y, Wang CR

Echinostoma hortense (Digenea: Echinostomatidae) is one of the intestinal flukes with medical importance in humans. However, the mitochondrial (mt) genome of this fluke has not been known yet. The present...
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Mitochondrial DNA A3243G mutation in noise-induced sensorineural hearing loss

Shin DH, Baek WK, Chung IS

  • KMID: 2028111
  • Korean J Occup Environ Med.
  • 2000 Sep;12(3):319-326.
OBJECTIVES: A different sequence change, in the mitochondrial tRNA gene, has been proposed as a candidate mutation in the sensorineurnal hearing loss. The purpose of current study is to...
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Complete Mitochondrial Genome of the Chagas Disease Vector, Triatoma rubrofasciata

Dong L, Ma X, Wang M, Zhu D, Feng Y, Zhang Y, Wang J

Triatoma rubrofasciata is a wide-spread vector of Chagas disease in Americas. In this study, we completed the mitochondrial genome sequencing of T. rubrofasciata. The total length of T. rubrofasciata mitochondrial...
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Synonymous Codon Usage Controls Various Molecular Aspects

Im EH, Choi SS

Synonymous sites are generally considered to be functionally neutral. However, there are recent contradictory findings suggesting that synonymous alleles might have functional roles in various molecular aspects. For instance, a...
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Complete Mitochondrial Genome of a Tongue Worm Armillifer agkistrodontis

Li J, He FN, Zheng HX, Zhang RX, Ren YJ, Hu W

Armillifer agkistrodontis (Ichthyostraca: Pantastomida) is a parasitic pathogen, only reported in China, which can cause a zoonotic disease, pentastomiasis. A complete mitochondrial (mt) genome was 16,521 bp comprising 13 protein-coding...
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A case of maternally inherited diabetes and deafness with rhabdomyolysis

Lee KH, Kim SE, Kim KY, Youn JW, Park SS, Yoo SH, Chung SC

  • KMID: 2081666
  • Korean J Med.
  • 2009 Apr;76(Suppl 1):S112-S116.
mutation at position 3,243 in the mtDNA-encoded tRNALeu (UUR) gene is associated with the syndrome of maternally inherited diabetes and deafness (MIDD). It is a rare form of diabetes...
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Incidence of Erythromycin Resistance Genes, erm(B) and mef(A), in Streptococci Isolated from Dental Plaques of Koreans

Kim YH, Lee SY

  • KMID: 1431095
  • Int J Oral Biol.
  • 2013 Jun;38(2):61-65.
Erythromycin is a macrolide antibiotic and inhibits bacterial protein synthesis by stimulating the dissociation of the peptidyl-tRNA molecule from the ribosomes during elongation. The use of macrolides has increased dramatically...
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Identification of Candida Species by Analysis of rRNA Spacer Regions

Lee MK, Kim HR, Ro BI

  • KMID: 1513658
  • Korean J Med Mycol.
  • 2006 Mar;11(1):13-18.
BACKGROUND: The genus Candida comprises 163 species, the most common pathogen in the genus is C. albicans, however, other Candida species are considered as emergent pathogens. Because there are species-specific...
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Complete Mitochondrial Genome of Anoplocephala magna Solidifying the Species

Guo A

The 2 species of the genus Anoplocephala (Anoplocephalidae), A. perfoliata and A. magna, are among the most important equine cestode parasites. However, there is little information about their differences at...
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Complete Sequence of the Mitochondrial Genome of Spirometra ranarum: Comparison with S. erinaceieuropaei and S. decipiens

Jeon HK, Park H, Lee D, Choe S, Kang Y, Bia MM, Lee SH, Eom KS

This study was undertaken to determine the complete mitochondrial DNA sequence and structure of the mitochondrial genome of Spirometra ranarum, and to compare it with those of S. erinaceieuropaei and...
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The First Korean case of combined oxidative phosphorylation deficiency-17 diagnosed by clinical and molecular investigation

Kim YA, Kim YM, Lee YJ, Cheon CK

Combined oxidative phosphorylation deficiency-17 (COXPD-17) is very rare and is caused by homozygous or compound heterozygous mutations in the ELAC2 gene on chromosome 17p12. The ELAC2 gene functions as a...
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Screening for Mitochondrial DNA Mutations of MELAS tRNA Leu(3243), MERRF tRNA Lys(8344) in Korean IDDM Patients

Yoo HW

  • KMID: 1529886
  • J Korean Soc Pediatr Endocrinol.
  • 1997 Sep;2(2):233-240.
An A to G mutation at nucleotide 3243 or 8344 of the mitochondrial genome has been associated with insulin dependent diabetes mellitus(IDDM) and noninsulin dependent diabetes mellitus(NIDDM) in some patients...
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Inhibition of MUC1 biosynthesis via threonyl-tRNA synthetase suppresses pancreatic cancer cell migration

Jeong SJ, Kim JH, Lim BJ, Yoon I, Song JA, Moon HS, Kim D, Lee DK, Kim S

Mucin1 (MUC1), a heterodimeric oncoprotein, containing tandem repeat structures with a high proportion of threonine, is aberrantly overexpressed in many human cancers including pancreatic cancer. Since the overall survival rate...
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Sequence Analysis of Mitochondrial Genome of Toxascaris leonina from a South China Tiger

Li K, Yang F, Abdullahi , Song M, Shi X, Wang M, Fu Y, Pan W, Shan F, Chen W, Li G

Toxascaris leonina is a common parasitic nematode of wild mammals and has significant impacts on the protection of rare wild animals. To analyze population genetic characteristics of T. leonina from...
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STADIUM: Species-Specific tRNA Adaptive Index Compendium

Yoon J, Chung YJ, Lee M

Due to the increasing interest in synonymous codons, several codon bias-related terms were introduced. As one measure of them, the tRNA adaptation index (tAI) was invented about a decade ago....
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Identification of Acinetobacter Genospecies by Analysis of rRNA Spacer Regions

Lee SH, Lee MK, Park AJ, Choi ES

  • KMID: 1931950
  • Korean J Clin Pathol.
  • 2000 Feb;20(1):48-55.
BACKGROUND: Recently, the genus Acinetobacter have become increasingly important as nosocomial pathogens. Colonization and infection caused by multiresistant epidemic strains are common manifestations in intensive care units. Up to now...
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Transcriptome analysis reveals stimulus-specific functions of glutamylprolyl-tRNA synthetase

Lee EY, Kim HK, Lee JS, Kim MH

The aminoacyl-tRNA synthetases (ARSs) are ancient house-keeping enzymes that catalyze the ligation of tRNAs to their cognate amino acids in the first step of protein synthesis. During the evolution of...
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