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Dendritic eIF4E-binding Protein 1 (eIF4E-BP1) mRNA Is Upregulated by Neuronal Activation

Moon IS, Lee HJ, Park IS

Long-term synaptic plasticity requires addition of new proteins at the synaptic site. The local protein synthesis at subsynaptic sites confers advantageous mechanisms that would regulate the protein composition in local...
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Depletion of Mitochondrial DNA Stabilizes C1qTNF-Related Protein 6 mRNA in Muscle Cells

Kim MJ, Lee W, Park EJ, Park SY

Mutation and reduction of mitochondrial DNA (mtDNA) have been suggested as factors in the pathogenesis of several metabolic diseases. Recently, we demonstrated that C1qTNF-related protein-6 (CTRP6) is involved in fatty...
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Effect of curcumin on the interaction between androgen receptor and Wnt/beta-catenin in LNCaP xenografts

Hong JH, Lee G, Choi HY

PURPOSE: Curcumin is a nontoxic, chemopreventive agent possessing multifaceted functions. Our previous study showed that curcumin inhibits androgen receptor (AR) through modulation of Wnt/beta-catenin signaling in LNCaP cells. Therefore, we...
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Regulation of acetyl CoA carboxylase mRNA in rat liver by high carbohydrate diet and insulin

Choi DH, Choi JH, Whang SK, Kim YS

Acetyl CoA carboxylase contents in liver cytosol of rats refed a high carbohydrate diet or injected with insulin were measured by an immunoassay method in order to evaluate the...
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Helicobacter pylori Eradication Downregulates Cellular Inhibitor of Apoptosis Protein 2 in Gastric Carcinogenesis

Yoon H, Kim SG, Kim BK, Shin E, Kim N, Lee HJ, Kang GH, Jung HC

BACKGROUND/AIMS: To evaluate the expression of cellular inhibitor of apoptosis protein 2 (cIAP2) during gastric carcinogenesis after Helicobacter pylori (HP) infection and after HP eradication. METHODS: We divided non-cancer patients into...
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Serotonin transporter mRNA expression in the dorsal raphe nucleus of a tumor bearing mouse

Jahng JW, Choi SH, Cha MJ, Kim NY, Hwang SJ, Lee JH

  • KMID: 1033103
  • Exp Mol Med.
  • 2005 Feb;37(1):65-69.
This study was conducted to determine if an oral squamous cell carcinoma alters mRNA expression of serotonin transporter (5-HTT) in the central nervous system. KB cell line derived from a...
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Aberrant Hypomethylation of Solute Carrier Family 6 Member 12 Promoter Induces Metastasis of Ovarian Cancer

Sung HY, Yang SD, Park AK, Ju W, Ahn JH

PURPOSE: Ovarian cancer (OC) is the most fatal of gynecological malignancies with a high rate of recurrence. We aimed to evaluate the expression of solute carrier family 6, member 12...
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A novel method using edge detection for signal extraction from cDNA microarray image analysis

Kim JH, Kim HY, Lee YS

  • KMID: 1085744
  • Exp Mol Med.
  • 2001 Jun;33(2):83-88.
Gene expression analyses by probes of hybridization from mRNA to cDNA targets arrayed on membranes or activated glass surfaces have revolutionized the way of profiling mega level gene expression. The...
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Expression of placenta growth factor mRNA in the rat placenta during mid-late pregnancy

Choi WS, Cho GJ, Won CK, Koh PO

  • KMID: 1091196
  • J Vet Sci.
  • 2005 Sep;6(3):179-183.
The placenta is an essential organ that synthesizes several growth and angiogenic factors for its own growth as well as fetal development. It is known that the placenta growth factor...
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Hypoxia Induces Connective Tissue Growth Factor mRNA Expression

Lee YK, Kim EJ, Lee JE, Noh JW, Kim YG

Connective tissue growth factor (CTGF) is known to be a profibrotic growth factor, which mediate the fibrotic effect of transforming growth factor-beta(TGF-beta) and to stimulate cell proliferation and matrix production....
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Effect of IgA Aggregates on Transforming Growth Factor-beta1 Production in Human Mesangial Cells and the Intraglomerular Expression of Transforming Growth Factor-beta1 in Patients with IgA Nephropathy

Han SY, Ihm CG, Cha DR, Kang YS, Han KH, Kim HK, Han JY

BACKGROUND: Transforming growth factor-beta (TGF-beta) stimulates renal fibrosis in various renal diseases including IgA nephropathy. METHODS: We examined whether immunoglobulin A (IgA) stimulated TGF-beta1 synthesis in human mesangial cells (MCs),...
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Circadian Rhythm of Surfactant Protein A, B and C mRNA in Rats

Kim CM, Sohn JW, Yoon HJ, Shin DH, Park SS

  • KMID: 1106139
  • Korean J Intern Med.
  • 2003 Jun;18(2):76-82.
BACKGROUND: All organisms have developed an internal timing system capable of reacting to and anticipating environmental stimuli with a program of appropriately timed metabolic, physiologic and behavioral events. The alveolar...
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Molecular identification of Ca(2+)channels in human sperm

Park JY, Ahn HJ, Gu JG, Lee KH, Kim JS, Kang HW, Lee JH

  • KMID: 1109318
  • Exp Mol Med.
  • 2003 Aug;35(4):285-292.
The acrosome reaction is a Ca(2+)-dependent exocytotic process that is a prerequisite step for fertilization. External calcium entry through voltage-activated Ca(2+)channels is known to be essential in inducing the acrosome...
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Gene Expression Changes in a Rat Model of Oxygen-Induced Retinopathy

Lee NE, Park YJ, Chung IY, Seo SW, Park JM, Yoo JM, Song JK

PURPOSE: To identify altered patterns of retinal mRNA expression in a rat model of oxygen-induced retinopathy (OIR). METHODS: Sprague-Dawley rats from P2 to P14 were exposed to hyperoxia (80% oxygen) to...
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Relationships Between the Expressions of CDX1 and CDX2 mRNA and Clinicopathologic Features in Colorectal Cancers

Kim GH, Lee DH, Kim HW, Cheong JY, Seo SB, Heo J, Kang DH, Song GA, Cho M, Yang US, Park DY, Yoo MA

BACKGROUND: CDX1 and CDX2 are members of the caudal-type homeobox gene family and control the proliferation and differentiation of intestinal mucosal cells. Their expressions are commonly reduced in colorectal cancer,...
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Treatment Outcome of Multidrug Resistance Related mRNA Expression and c-Jun-N-Terminal Kinase Activity in Patients with Acute Myeloid Leukemia

Do JH, Oh SH, Song EJ, Chung JS, Kang CD, Lee EY

BACKGROUND: The multidrug resistance (mdr1), multidrug resistance associated protein (mrp1), and glutathione-s-transferase (gst) pi genes have been associated with treatment failure in acute myeloid leukemia (AML). c-jun N-terminal kinase...
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