- Expression of p53 and MDM2 Proteins in Thyroid Carcinomas
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Lee CH
- KMID: 2037282
- Korean J Pathol.
- 1998 Apr;32(4):255-260.
The nuclear protein p53 is a tumor suppressor gene product that functions in pathways of cell cycle control and in the repair of damaged DNA. The MDM2 gene codes for... -
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- Immunohistochemical Expression of p53, p21, and mdm2 Proteins in Human Papillomavirus Positive and Negative Invasive Uterine Cervical Carcinomas
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Park IS, Han HS, Kim TS, Han JY, Kim JM, Chu YC, Hwang TS
- KMID: 2275606
- Korean J Pathol.
- 2001 Jun;35(3):212-219.
BACKGROUND: In the uterine cervical carcinoma, the inactivation of p53 protein by human papillomavirus(HPV) E6 protein has been reported to play a greater role in carcinogenesis than the mutation of... -
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- Leiomyosarcoma of the Esophagus: Report of two cases, one with associated squamous cell carcinoma
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Ko SK, Huh MH
- KMID: 2141068
- Korean J Pathol.
- 1995 Dec;29(6):783-791.
Two new cases of leiomyosarcoma of the esophagus, one with an associated squamous cell carcinoma, are presented with review of literature. lmmunohistochemical study of MDM2 gene is performed upon these... -
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- Immunohistochemical Study of p53 and MDM2 Expression on the Epithelial Tumors of the Skin
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Cho HS, Park EJ, Kim CW, Cho HJ, Kim KH, Kim KJ, Park HR
- KMID: 2302183
- Korean J Dermatol.
- 2007 Jun;45(6):534-540.
BACKGROUND: MDM2 (mouse double minute 2), the product of an oncogene is a key regulator of p53. It can repress transcription of p53 and eliminate it through proteolytic degradation. On... -
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- Expression of MDM-2 and p53 Proteins in Gastric Adendegrees Carcinoma and Its Relationship with Clinicopathologic Factors
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Yang JW, Kim HJ, Lee TJ, Park ES, Yoo JH
- KMID: 2175011
- J Korean Cancer Assoc.
- 2000 Jun;32(3):476-486.
PURPOSE: MDM-2 is an oncoprotein that inhibits p53 tumor-suppressor protein. These abnor malities have a role in tumorigenesis through inactivation of p53 function. To determine the clini copathological and prognostic value of... -
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- Functional characterization of human oncoprotein gankyrin in Zebrafish
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Kim SY, Hur W, Choi JE, Kim D, Wang JS, Yoon HY, Piao LS, Yoon SK
- KMID: 756281
- Exp Mol Med.
- 2009 Jan;41(1):8-16.
- doi: 10.3858/emm.2009.41.1.002
Gankyrin is an oncoprotein containing seven ankyrin repeats that is overexpressed in hepatocellular carcinoma (HCC). Gankyrin binds to Mdm2, which results in accelerated ubiquitylation via degradation of p53, and it... -
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- Aberrant Expression of p53, MCM2 Protein and Proliferative Activity in Glioma
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Chung DS, Park YS, Huh PW, Kim MC, Lee GS, Choi CR
- KMID: 2067358
- J Korean Neurosurg Soc.
- 1996 Jan;25(1):52-59.
In gliomas, the most frequently studied tumor suppressor gene is the p53 gene which has been found to be mutated in a considerable fraction of astrocytomas and glioblastomas. Mutations that... -
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- Expression of p53 and MDM-2 Protein in Cervical Neoplasia
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Chung CW, Shin YK, Park CW, Kim CJ, Cho TI, Park ES
- KMID: 2261546
- Korean J Obstet Gynecol.
- 1999 Oct;42(10):2264-2269.
OBJECTIVES: MDM-2 is an oncoprotein that inhibits p53 tumor suppressor protein. Amplication and over- expression of its protein have been observed in human malignancies, and these abnormalities have a role... -
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- Expressions of the p53 and MDM-2 Genes in Primary Chondrosarcoma and Secondary Chondrosarcoma from Osteochondromatosis
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Yang JY, Rhee KJ, Lee JK, Kim YM, Kang C, Ahn SH, Ryou CH
- KMID: 2023243
- J Korean Orthop Assoc.
- 2003 Dec;38(7):763-767.
PURPOSE: To evaluate the relationships between mutations of the p53 and MDM-2 proteins in human primary chondrosarcoma and in secondary chondrosarcoma from osteochondromatosis. MATERIALS AND METHODS: From January, 1984 to... -
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- An Immunohistochemical Study of mdm - 2 Protein Expression in Malignant Skin Tumors
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Cho JH, Ro YS
- KMID: 1891531
- Korean J Dermatol.
- 1996 Aug;34(4):538-545.
BACKGROUND: The human homologue of mouse double minute 2(mdm-2) gene codes for a cellular protein that forms a complex with the mutant and wild type p53 protein and modulates its... -
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- Aberrant Cell Cycle Regulation in Cervical Carcinoma
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Kim YT, Zhao M
- KMID: 2158138
- Yonsei Med J.
- 2005 Oct;46(5):597-613.
- doi: 10.3349/ymj.2005.46.5.597
Carcinoma of the uterine cervix is one of the most common malignancies among women worldwide. Human papillomaviruses (HPV) have been identified as the major etiological factor in cervical carcinogenesis. However,... -
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- Study On Mutation Of P53 And Expression Of Mdm-2 In Dmba Induced Carcinoma Of Hamster Buccal Pouch
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Park YS, Kim KW, Lee JH, Kim CJ
- KMID: 2118272
- J Korean Assoc Oral Maxillofac Surg.
- 2001 Oct;27(5):373-384.
Cellular proliferation is an intricately regulated process mediated by the coordinated interactions of critical growth control genes.Two of these factors in mammalian cells are the p53 and mdm-2 genes. A... -
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