- Immunoradiometric assay of human proinsulin and partially processed proinsulin with use of monoclonal antibody and streptavidin-biotin labeling
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Kim JQ, Cho HI, Kim SI, Lee HK, Hales CN
- KMID: 1421467
- J Korean Med Sci.
- 1989 Dec;4(4):171-177.
- doi: 10.3346/jkms.1989.4.4.171
The sensitive and specific immunoradiometric assay is described for human proinsulin and its intermediate peptides (65-66 split and 32-33 split proinsulin). We developed a monoclonal antibody-based two-site immunoradiometric assay with... -
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- Plasma Proinsulin Levels among the Control, Impaired Glucose Tolerance and Type 2 Diabetes Mellitus during Oral Glucose Tolerance Test
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Lee MD, Kim YU, Kim HS, Shin YG, Chung CH
- KMID: 2331720
- J Korean Diabetes Assoc.
- 1999 Apr;23(2):147-154.
BACKGROUND: Increased secretion of proinsulin has been associated with beta-cell dysfunction. Hyper-proinsulinemia is suggested to be a predictor for the progression of IGT to type 2 DM. In this study,... -
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- Serum insulin, proinsulin, and proinsulin/insulin ratio in type 2 diabetic patients
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Kim NH, Oh JH, Choi KM, Kim YH, Kim SJ, Baik SH, Choi DS
- KMID: 2251336
- Korean J Med.
- 2000 Jan;58(1):67-74.
BACKGROUND: Although insulin resistance and decreased insulin secretion are characteristics of establised type 2 DM, which of these metabolic abnormalities is the primary determinant of type 2 DM is controversial. It is... -
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- Serum Insulin, Proinsulin and Proinsulin/Insulin Ratio in Type 2 Diabetic Patients: As an Index of beta-Cell Function or Insulin Resistance
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Kim NH, Kim DL, Choi KM, Baik SH, Choi DS
- KMID: 759518
- Korean J Intern Med.
- 2000 Dec;15(3):195-201.
BACKGROUND: Although insulin resistance and decreased insulin secretion are characteristics of established type 2 DM, which of these metabolic abnormalities is the primary determinant of type 2 DM is controversial.... -
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- Serum Fasting Proinsulin Level as a Predictor for Development of NIDDM in Korean Subjects
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Park GS, Shin CS, park KS, Kim SY, Lee HK, Kwon SJ, Park YS
- KMID: 2008319
- J Korean Diabetes Assoc.
- 1997 Dec;21(4):365-371.
BACKGROUND: Proinsulin is raised in people with NIDDM. Hyperproinsulinemia is thought to be a predictor for the subsequent development of NIDDM. We studied to investigate whether hyperproinsulinemia can predict the... -
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- Serum Proinsulin Responses during Oral Glucose Tolerance Test in patients with Non-insulin Dependent Diabetes Mellitus
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Nam MS, Hong SB, Kim YJ, Kim MR, Kim YS, Hyun IY, Kwak IH
- KMID: 2008318
- J Korean Diabetes Assoc.
- 1997 Dec;21(4):356-364.
BACKGROUND: When insulin is secreted from the pancreas, a small amount of proinsulin is also secreted at the same time. Pancreatic beta cell may release immature granules richer in proinsulin... -
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- Plasma Proinsulin Secretion in Impaired Glucose Tolerance and Newly Diagnosed Type 2 Diabetes Mellitus
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Kong BH, Choi SJ, Kim JT, Oh YS, Shinn SH
- KMID: 1905892
- J Korean Diabetes Assoc.
- 2000 Aug;24(4):467-475.
BACKGROUND: Type 2 diabetes mellitus is characterized beta cell dysfunction and insulin resistance but the relative roles of the two factors are different in various ethnic groups. The changes in... -
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- Insulin Secretory Dysfunction in the Patients with Untreated Hyperthyroidism
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Nam MS, Shin SY, Kim YW, Hong SB, Kim YJ, Kim MR, Choe WS, Kim YS
- KMID: 2331674
- J Korean Diabetes Assoc.
- 1998 Sep;22(3):320-327.
BACKGROUND: Abnormal glucose metabolism with impaired glucose tolerance has been documented in patients with thyrotoxicosis, but the pathogenesis is not fully understood. Therefore, the aim of the present study was... -
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- Development of Proinsulin-secreting Non-endocrine Cell
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Yoon DJ, Kim SH, Kim JW, Kim YK, Song YD, Ahn YH
- KMID: 2331690
- J Korean Diabetes Assoc.
- 1998 Dec;22(4):467-474.
BACKGROUND: Recently, the advent of genetic engineering technics enabled. us to transfer foreign genes of interests into various cells and establish an "artificial b-cells" capable of secreting insulin in response... -
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- Mesenchymal Stem Cell Differentiation into Adipocytes Is Equally Induced by Insulin and Proinsulin In Vitro
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Pfützner , Schipper D, Pansky A, Kleinfeld , Roitzheim , Tobiasch E
- KMID: 2400869
- Int J Stem Cells.
- 2017 Nov;10(2):154-159.
- doi: 10.15283/ijsc17033
BACKGROUND AND OBJECTIVES: In advanced β-cell dysfunction, proinsulin is increasingly replacing insulin as major component of the secretion product. It has been speculated that proinsulin has at least the same... -
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- Complex Partial Seizure Like Symptoms Presented by a Patient with Insulinoma and Hyperproinsulinemia
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Do YR, Kwon OD, Kim JE, Do JK, Lee DK
- KMID: 1640575
- J Korean Epilepsy Soc.
- 2004 Dec;8(2):167-170.
Insulinoma with hyperproinsulinemia and normal serum insulin level is a rare disease. Because of the neuroglycopenic symptoms, the initial diagnosis tends to be made as epilepsy or as psychosis. A... -
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- Impaired Insulin Secretion in Normoglycemic Offspring of Patients with Type 2 Diabetes
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Byun EK, Hong YS, Oh JY, Sung YA, Jang YJ
- KMID: 2008105
- J Korean Diabetes Assoc.
- 2003 Feb;27(1):39-48.
BACKGROUND: Although it is well known that insulin secretory defects and insulin resistance are major pathogenetic factors of type 2 diabetes, their relative importance still remains controversial in various ethnic... -
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- Serum Proinsulin, Proinsulin/Total Insulin Ratio and Insulin Resistance in Elderly-onset Type 2 Diabetes
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Oh YJ, Park YJ, Kim YW, Kim SK, Hong SB, Kim YJ, Kim MR, Nam MS, Kim YS
- KMID: 2331739
- J Korean Diabetes Assoc.
- 2001 Apr;25(2):113-124.
BACKGROUND: It is well known that the concentration of serum proinsulin and the ratio of proinsulin/total insulin (P/I) are elevated in type 2 diabetes. Proinsulin is produced by the ribosome... -
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- Serum Leptin in Cord Blood and Its Relation with Birth Weight and Metabolic Parameters
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Park DJ, Lee YY, Park KS, Kim SY, Cho BY, Lee HG, Park GS, Jun JK, Yoon BH
- KMID: 2199467
- J Korean Soc Endocrinol.
- 1999 Jun;14(2):365-371.
BACKGROUND: Leptin, produced in the adipose tissue, is involved in the regulation of body weight. The release of the leptin is increased in obese adults even in children. This study... -
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- Structural Analysis of Recombinant Human Preproinsulins by Structure Prediction, Molecular Dynamics, and Protein-Protein Docking
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Jung SH, Kim CK, Lee G, Yoon J, Lee M
- KMID: 2404051
- Genomics Inform.
- 2017 Dec;15(4):142-146.
- doi: 10.5808/GI.2017.15.4.142
More effective production of human insulin is important, because insulin is the main medication that is used to treat multiple types of diabetes and because many people are suffering from... -
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- Leptin Concentration in Diabetin and Non-diabetin Subjects in the Community Population
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Lee KU, Hong SK, Kim SW, Kim YI, Chung YE, Lee MS, Park JY, Kim JY
- KMID: 2177950
- J Korean Diabetes Assoc.
- 1999 Aug;23(4):592-600.
BACKGROUND: It has been suggested that adipose tissue releases leptin, a satiety factor, which circulates in blood and acts on the hypothalamus to suppress appetite. However, serum leptin concentration in... -
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- The Role of beta-cell Dysfunction and Insulin Resistance in the Development of Post-renal Transplantation Diabetes Mellitus
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Nam JH, Lee HC, Ahn CW, Mun JI, Kim SI, Park K, Song YD, Lim SK, Kim KR, Huh KB
- KMID: 1905894
- J Korean Diabetes Assoc.
- 2000 Aug;24(4):485-514.
BACKGROUND: Our study was undertaken to investigate the pathogenesis and possible risk factors for post-renal transplantation diabetes mellitus (PTDM). METHODS: we recruited 114 patients with normal glucose tolerance, and performed the... -
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- Clinical Utility and Cross-Reactivity of Insulin and C-Peptide Assays by the Lumipulse G1200 System
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Oh J, Kim JH, Park HD
- KMID: 2429118
- Ann Lab Med.
- 2018 Nov;38(6):530-537.
- doi: 10.3343/alm.2018.38.6.530
BACKGROUND: Measurement of insulin and C-peptide concentrations is important for deciding whether insulin treatment is required in diabetic patients. We aimed to investigate the analytical performance of insulin and C-peptide... -
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- Microalbuminuria in Diabetic and Non-diabetic Subjects: A population Based Study
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Kim YI, Chung YE, Kim JY, Kim SW, Kim ES, Lee MS, Park JY, Hong SK, Lee KU
- KMID: 2177981
- J Korean Diabetes Assoc.
- 1999 Feb;23(1):79-86.
BACKGROUND: Microalbuminuria is associated with increased cardiovascular mortality in type 2 diabetic patients and non-diabetic subjects. This study was undertaken to determine the prevalence ot microalbuminuria among diabetic and non-diabetic... -
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- Insulin Gene Therapy using Vascular Smooth Muscle Cells in Diabetic Rats
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Oh TG, Lee MJ, Kim YK, Kim ST
- KMID: 1569043
- J Korean Diabetes Assoc.
- 2002 Feb;26(1):31-45.
BACKGROUND: Type 1 diabetes mellitus is caused by a lack of insulin. The purpose of this study was to test whether blood glucose control in severe diabetic animals can be... -
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