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Effects of Fluoxetine on Potassium Channels in Cat Gastric Smooth Muscle Cells

Choi JS, Sung JH, Choi JC, Choi BH, Hahn SJ, Yoon SH, Sim SS, Jo YH, Kim MS

  • KMID: 1571053
  • Korean J Gastroenterol.
  • 2000 Feb;35(2):144-153.
BACKGROUND/AIMS: In this study, the effects of fluoxetine on voltage-activated potassium channels and Ca2+-activated potassium channels were examined in isolated gastric smooth muscle cells of cat. We measured intracellular calcium levels. The...
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Alterations in Calcium-Activated Potassium Channel Expressions in Human Prostate Cancer

Kim DY, Yang EK, Kim JW

PURPOSE: Recent studies have shown that potassium (K+) and sodium channels are involved in prostate cell growth. However, a great many of the studies have been done in prostate cancer...
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Mechanical Hyperalgesia Induced by Blocking Calcium-activated Potassium Channels on Capsaicin-sensitive Afferent Fiber

Lee KH, Shin HK

  • KMID: 2285345
  • Korean J Physiol Pharmacol.
  • 2007 Oct;11(5):215-219.
Small and large conductance Ca2+-activated K+ (SKCa and BKCa) channels are implicated in the modulation of neuronal excitability. We investigated how changes in peripheral KCa channel activity affect mechanical sensitivity...
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Role of Nicotinic Acetylcholine Receptor on Efferent Inhibition in Cochlear Hair Cell

Im GJ

The alpha9alpha10 nicotinic acetylcholine receptors (nAChRs) mediates efferent inhibition of hair cell function within the auditory sensory organ. Gating of the nAChRs leads to activation of calcium-dependent potassium channels to...
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Spike Frequency Adaptation in Neurons of the Central Nervous System

Ha GE, Cheong E

Neuronal firing patterns and frequencies determine the nature of encoded information of the neurons. Here we discuss the molecular identity and cellular mechanisms of spike-frequency adaptation in central nervous system...
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The large-conductance calcium-activated potassium channel holds the key to the conundrum of familial hypokalemic periodic paralysis

Kim JB, Kim SJ, Kang SY, Yi JW, Kim SM

PURPOSE: Familial hypokalemic periodic paralysis (HOKPP) is an autosomal dominant channelopathy characterized by episodic attacks of muscle weakness and hypokalemia. Mutations in the calcium channel gene, CACNA1S, or the sodium...
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Characteristics of Potassium Channel in the Isolated Rat Detrusor Muscle

Jang MS, Choi EM, Ha JH, Lee KY, Kim WJ

The purpose of this study was to investigate the characteristics or the potassium channels existing in the rat urinary bladders. Smooth muscle strips of rat detrusor urinae were examined by isometric...
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The alteration of Ca2+-activated K+ channels in coronary arterial smooth muscle cells isolated from isoproterenol-induced cardiac hypertrophy in rabbit

Kim N, Han J, Kim EY

  • KMID: 2285235
  • Korean J Physiol Pharmacol.
  • 2001 Apr;5(2):147-156.
It has been proposed that Ca2+-activated K+ (KCa) channels play an essential role in vascular tone. The alterations of the properties of coronary KCa channels have not been studied as a possible...
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Roles of Ca2+ activated K+ conductances on spontaneous firing patterns of isolated rat medial vestibular nucleus neurons

Chun SW, Jun JW, Park BR

  • KMID: 1580629
  • Korean J Physiol Pharmacol.
  • 2000 Feb;4(1):1-8.
To investigate the contributions of intrinsic membrane properties to the spontaneous activity of medial vestibular nucleus (MVN) neurons, we assessed the effects of blocking large and small calcium-activated potassium channels by means of...
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Dual action of d-tubocurarine on large-conductance Ca2+-activated K+ channels from rat brain reconstituted into planar lipid bilayer

Chung S, Shin JH

  • KMID: 2071534
  • Korean J Physiol Pharmacol.
  • 1998 Oct;2(5):549-553.
Using the planar lipid bilayer method, we investigated the effect of d-tubocurarine (dTC) on the extracellular side of large-conductance Ca2+-activated K+ channel from rat brain. When the initial open probability (Po) of the...
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Identification of a Calcium-activated Potassium Channel Gene Expressed in Rat Cardiac Myocytes

Park IS, Jeon HK, Kim NS, Ahn YM, Park CS, Lee HB

  • KMID: 2335491
  • J Korean Pediatr Soc.
  • 2000 Jul;43(7):905-912.
PURPOSE: Calcium-activated potassium channels(KCa) may be involved in the transient outward current of the first phase of cardiac action potential. But it is still not clear whether cardiac myocytes express any Kca....
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Differential Functional Expression of Clotrimazole-sensitive Ca2+-activated K+ Current in Bal-17 and WEHI-231 Murine B Lymphocytes

Zheng H, Ko JH, Nam JH, Earm YE, Kim SJ

  • KMID: 1512937
  • Korean J Physiol Pharmacol.
  • 2006 Feb;10(1):19-24.
The intermediate conductance Ca2+-activated K+ channels (SK4, IKCa1) are present in lymphocytes, and their membrane expression is upregulated by various immunological stimuli. In this study, the activity of SK4 was...
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17Beta-Estradiol Inhibits Calcium-Activated Potassium Channel Expressions in Rat Whole Bladder

Kim DY, Yang EK

PURPOSE: To investigate the effect of estrogen on the expression of calcium-activated potassium (KCa) channels in an overactive bladder rat model. To this end, mRNA and protein levels of KCa...
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Effects of Nitric Oxide on Voltage-dependent Potassium Currents in Vestibular Nuclear Neuron of the Rat

Jeong HS, Lee GO, Kim JH, Heo T, Moon JY, Park JS

  • KMID: 1807454
  • Chonnam Med J.
  • 2000 Jun;36(2):129-138.
The effect of the nitrix oxide (NO) pathway on voltage-dependent potassium currents in rat vestibular nuclear neurons was investigated by using the whole cell patch clamp technique. When cells were...
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Increased activity of large conductance Ca2+-activated K+ channels in negatively-charged lipid membranes

Park JB, Ryu PD

  • KMID: 2285216
  • Korean J Physiol Pharmacol.
  • 1998 Aug;2(4):529-539.
The effects of membrane surface charge originated from lipid head groups on ion channels were tested by analyzing the activity of single large conductance Ca2+-activated K+ (maxi K) channel from rat skeletal muscle....
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Altered Expressions of Calcium-Activated Potassium Channel and Connexin in Bladder Mucosae of Stress Urinary Incontinence Patients with Overactive Bladder Symptoms

Kim DY, Kim JW, Yang EK

PURPOSE: The aim of this study was to examine how the mRNA and protein levels of calcium activated Kchannel (K(Ca)) and connexin (Cx) change in association with overactive bladder in...
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Effects of Pinacidil, Tetrathylammonium and Glibenclamide on Hypoxic Vasoconstriction in Isolated Perfused Rabbit Lungs

Ro YJ, Yun WH, Kim CS, Min SW, Kim SD, Kim YL

BACKGROUND: This study investigated the effects of the K+ channel opener, pinacidil on hypoxic pulmonary vasoconstriction in isolated perfused rabbit lungs. In order to evaluate the vasodilatation mechanism of K+...
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Intracellular calcium-dependent regulation of the sperm-specific calcium-activated potassium channel, hSlo3, by the BK(Ca) activator LDD175

Wijerathne TD, Kim J, Yang D, Lee KP

Plasma membrane hyperpolarization associated with activation of Ca²⁺-activated K⁺ channels plays an important role in sperm capacitation during fertilization. Although Slo3 (slowpoke homologue 3), together with the auxiliary γ2-subunit, LRRC52...
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Characteristics of K+ Outward Currents in the Cochlear Outer Hair Cells of Circling Mice within the First Postnatal Week

Ahn JW, Kang SW, Ahn SC

K+ outward currents in the outer hair cells (OHCs) of circling mice (homozygous (cir/cir) mice), an animal model for human deafness (DFNB6 type), were investigated using a whole cell patch...
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Modulation of outward potassium currents by nitric oxide in longitudinal smooth muscle cells of guinea-pig ileum

Kwon SC, Rim SJ, Kang BS

  • KMID: 1562325
  • Korean J Physiol Pharmacol.
  • 1998 Apr;2(2):225-232.
To investigate the possible involvement of outward potassium (K+) currents in nitric oxide-induced relaxation in intestinal smooth muscle, we used whole-cell patch clamp technique in freshly dispersed guinea-pig ileum longitudinal smooth muscle cells....
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