- Three Patients With Classic and Atypical Neurodegeneration With Brain Iron Accumulation
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Lee SY, Lyoo CH, Seo KD, Lee MS
- KMID: 2185069
- J Korean Neurol Assoc.
- 2008 Aug;26(3):243-246.
Neurodegeneration with brain iron accumulation (NBIA) is a disorder characterized by various mixtures of extrapyramidal, pyramidal or psychiatric abnormalities associated with iron accumulation in the basal ganglia. The mutations in... -
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- A Novel PANK2 Mutation in a Patient with Atypical Pantothenate-Kinase-Associated Neurodegeneration Presenting with Adult-Onset Parkinsonism
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Seo JH, Song SK, Lee PH
- KMID: 2287649
- J Clin Neurol.
- 2009 Dec;5(4):192-194.
- doi: 10.3988/jcn.2009.5.4.192
BACKGROUND: Pantothenate-kinase-associated neurodegeneration (PKAN) is an autosomal recessive neurodegenerative disorder that is characterized by progressive extrapyramidal signs, visual loss, and cognitive impairment. PKAN is caused by mutations in the pantothenate... -
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- A Global Gene Expression Analysis of the Peripheral Blood Mononuclear Cells Reveals the Gene Expression Signature in Psoriasis
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Lee SK, Jeon EK, Kim YJ, Seo SH, Kim CD, Lim JS, Lee JH
- KMID: 2266283
- Ann Dermatol.
- 2009 Aug;21(3):237-242.
- doi: 10.5021/ad.2009.21.3.237
BACKGROUND: Psoriasis is a chronic inflammatory skin disease that affects approximately 1~3% of the general population. OBJECTIVE: We performed cDNA microarray analysis with using the dendrimer labelling method to investigate the... -
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- A Case of Retinal Pigmentary Degeneration in PKAN
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Jo SH, Cheon CK, Kim YU, Jung JH
- KMID: 2216778
- J Korean Ophthalmol Soc.
- 2013 Mar;54(3):529-533.
- doi: 10.3341/jkos.2013.54.3.529
PURPOSE: Pantothenate kinase-associated neurodegeneration (PKAN), also known as neurodegeneration with brain iron accumulation is an extremely rare degenerative disease. The present study reports a case of retinal pigmentary changes in... -
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- Protective Effects of K6PC-5, A Sphingosine Kinase Activator, Against 1-methyl-4-phenylpyridinium-induced Dopaminergic Neuronal Cell Death
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Jang S, Choi SS, Kim SH, Park JS, Jeong HS
- KMID: 2172296
- Chonnam Med J.
- 2008 Dec;44(3):162-168.
- doi: 10.4068/cmj.2008.44.3.162
Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metaolite, regulates multiple cellular responses such as Ca2+ signaling, cellular growth and survival, and differentiation. Sphingosine kinase (SphK) is a key enzyme in modulating the... -
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- Phosphatidylinositol 4-phosphate 5-kinase alpha negatively regulates nerve growth factor-induced neurite outgrowth in PC12 cells
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Liu T, Lee SY
- KMID: 2154235
- Exp Mol Med.
- 2013 Mar;45(3):e16.
Neurite outgrowth, a cell differentiation process involving membrane morphological changes, is critical for neuronal network and development. The membrane lipid, phosphatidylinositol (PI) 4,5-bisphosphate (PIP2), is a key regulator of many... -
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- Detection of MYCN Amplification in Serum DNA Using Conventional Polymerase Chain Reaction
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Ma Y, Lee JW, Park SJ, Yi ES, Choi YB, Yoo KH, Sung KW, Koo HH
- KMID: 2468270
- J Korean Med Sci.
- 2016 Sep;31(9):1392-1396.
- doi: 10.3346/jkms.2016.31.9.1392
Neuroblastoma (NB) is the most common extra-cranial solid tumor of childhood and is characterized by a wide range of clinical behaviors. Amplification of MYCN is a well-known poor prognostic factor... -
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- N-acetyl-D-glucosamine kinase interacts with dynein light-chain roadblock type 1 at Golgi outposts in neuronal dendritic branch points
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Islam MA, Sharif SR, Lee H, Seog DH, Moon IS
- KMID: 2155431
- Exp Mol Med.
- 2015 Aug;47(8):e177.
- doi: 10.1038/emm.2015.48
N-acetylglucosamine kinase (GlcNAc kinase or NAGK) is a ubiquitously expressed enzyme in mammalian cells. Recent studies have shown that NAGK has an essential structural, non-enzymatic role in the upregulation of... -
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- ITPKC and SLC11A1 Gene Polymorphisms and Gene-Gene Interactions in Korean Patients with Kawasaki Disease
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Kim KY, Bae YS, Ji W, Shin D, Kim HS, Kim DS
- KMID: 2418858
- Yonsei Med J.
- 2018 Jan;59(1):119-127.
- doi: 10.3349/ymj.2018.59.1.119
PURPOSE: Kawasaki disease (KD) is an acute systemic vasculitis. Both the etiology of KD and the erythema of Bacille Calmette-Guérin (BCG) injection sites observed in the disease are poorly understood.... -
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- Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells
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Lee WJ, Yoo HS, Suh PG, Lim JS, Oh S, Lee YM
- KMID: 1123763
- Exp Mol Med.
- 2004 Oct;36(5):420-427.
FTY720, a synthetic sphingoid base analog, was examined as a new sphingosine kinase inhibitor, which converts endogenous sphingosine into its phosphate form. With 20 micrometer of FTY720, sphingosine accumulated in... -
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- Phosphatidylinositol 4-phosphate 5-kinase alpha is induced in ganglioside-stimulated brain astrocytes and contributes to inflammatory responses
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Lee SY, Kim B, Yoon S, Kim YJ, Liu T, Woo JH, Chwae YJ, Joe EH, Jou I
- KMID: 983958
- Exp Mol Med.
- 2010 Sep;42(9):662-673.
- doi: 10.3858/emm.2010.42.9.066
In brain tissue, astrocytes play defensive roles in central nervous system integrity by mediating immune responses against pathological conditions. Type I phosphatidylinositol 4-phosphate 5-kinase alpha (PIP5Kalpha) that is responsible for... -
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- Low dietary inorganic phosphate affects the lung growth of developing mice
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Xu CX, Jin H, Chung YS, Shin JY, Hwang SK, Kwon JT, Park SJ, Lee ES, Minai-Tehrani A, Chang SH, Woo MA, Noh MS, An GH, Lee KH, Cho MH
- KMID: 1102966
- J Vet Sci.
- 2009 Jun;10(2):105-113.
- doi: 10.4142/jvs.2009.10.2.105
Inorganic phosphate (Pi) plays a critical role in diverse cellular functions, and regulating the Pi balance is accomplished by sodium-dependent Pi co-transporter (NPT). Pulmonary NPT has recently been identified in... -
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