- Inhibition of porcine pancreatic phospholipase A2 by JE-1 andlipocortin: effective binding to phosphatidylcholine
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Nam KS, Choe IS, Chung TW
- KMID: 1690361
- Korean J Immunol.
- 1991 Nov;13(2):225-230.
No abstract available. -
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- The effects of high glucose concentration on phospholipase A2 activity in cultured rat mesangial cells
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Choi KH, Nemenoff R
- KMID: 1694472
- Korean J Nephrol.
- 1993 Dec;12(4):523-532.
No abstract available. -
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- Effects of Phospholipase A2 Inhibitor, Ochnaflavone, on the TNF-alpha and NO Production in Macrophages
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Kim JH, Jin C, Hong JG, Seo PG, Baek SH
- KMID: 1573070
- Korean J Immunol.
- 2000 Sep;22(3):157-163.
No abstract available. -
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- Moxifloxacin Alleviates Oleic Acid-provoked Neutrophilic Respiratory Burst in the Rat Lung through the Inhibition of Cytosolic Phospholipase A2
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Lee YM
- KMID: 2114619
- Tuberc Respir Dis.
- 2010 Oct;69(4):256-264.
- doi: 10.4046/trd.2010.69.4.256
BACKGROUND: According to the notion of the immunoregulatory functions of moxifloxacin (MFX), the effect of MFX on the neutrophilic respiratory burst in conjunction with the expression of cytosolic phospholipase A2... -
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- The Production of Phospholipase A2 in Different Types of Cultured Human Intervertebral Disc Cells
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Kim DJ, Wang JM
- KMID: 2322800
- J Korean Soc Spine Surg.
- 2000 Mar;7(1):1-8.
STUDY DESIGN: Evaluation of phospholipase A2 production according to cell type of human intervertebral disc. SUMMARY OF LITERATURE REVIEW: It was reported that the phospholipase A2 activity in human lumbar disc... -
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- Serum Phospholipase A2 Activities in Patients with Chronic Liver Disease
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Lee JM, Kweon YO, Kim NS
- KMID: 1770639
- Korean J Hepatol.
- 1997 Jun;3(2):170-178.
BACKGROUND/PURPOSE: Phospholipase A (PLAq) is an rate-limiting enzyme hydrolyzing arachidonic acid from the sn-2 position of membrane phospholipids. In vitro studies demonstrated that the enzyme could be secreted into extracellular mileu by pro-inflammatory... -
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- Mediation of intracellular Ca2+ in the phospholipase A2-induced cell proliferation in human neuroblastoma cells
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Kim JA, Lee YS
- KMID: 2285203
- Korean J Physiol Pharmacol.
- 1998 Aug;2(4):411-417.
The role of phospholipase A2 (PLA2) in tumor cell growth was investigated using SK-N-MC human neuroblastoma cells. 4-Bromophenacyl bromide (BPB) and mepacrine (Mep), known PLA2 inhibitors, suppressed growth of the tumor cells in... -
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- Morinda citrifolia Inhibits Both Cytosolic Ca2+-dependent Phospholipase A2 and Secretory Ca2+-dependent Phospholipase A2
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Song HS, Park SH, Ko MS, Jeong JM, Sohn UD, Sim SS
- KMID: 2285398
- Korean J Physiol Pharmacol.
- 2010 Jun;14(3):163-167.
- doi: 10.4196/kjpp.2010.14.3.163
This study investigated the effects of the methanol extracts of Morinda citrifolia containing numerous anthraquinone and iridoid on phospholipase A2 (PLA2) isozyme. PLA2 activity was measured using various PLA2 substrates,... -
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- Prognostic significance of cytosolic phospholipase A2 expression in patients with colorectal cancer
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Yoo YS, Lim SC, Kim KJ
- KMID: 2212184
- J Korean Surg Soc.
- 2011 Jun;80(6):397-403.
- doi: 10.4174/jkss.2011.80.6.397
PURPOSE: Cyclooxygenase-2 is believed to be an important enzyme in the pathogenesis of colorectal cancer (CRC). Cytosolic phospholipase A2 (cPLA2), also, have been suggested to be related to the carcinogenesis... -
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- Effect of Extremely Low Frequency Electromagnetic Fields (EMF) on Phospholipase Activity in the Cultured Cells
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Song HS, Kim HR, Ko MS, Jeong JM, Kim YH, Kim MC, Hwang YH, Sohn UD, Gimm YM, Myung SH, Sim SS
- KMID: 2071716
- Korean J Physiol Pharmacol.
- 2010 Dec;14(6):427-433.
- doi: 10.4196/kjpp.2010.14.6.427
This study was conducted to investigate the effects of extremely low frequency electromagnetic fields (EMF) on signal pathway in plasma membrane of cultured cells (RAW 264.7 cells and RBL 2H3... -
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- Phospholipase A2 Contributes to Hemorrhage-induced Acute Lung Injury Through Neutrophilic Respiratory Burst
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Jang YS, Kim SE, Jheon SH, Shin TR, Lee YM
- KMID: 2160039
- Tuberc Respir Dis.
- 2001 Dec;51(6):503-516.
- doi: 10.4046/trd.2001.51.6.503
BACKGROUND: The present study was carried out in association with neutrophilic respiratory burst in the lung in order to clarify the pathogenesis of acute respiratory distress syndrome(ARDS) following acute severe... -
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- The Production Mechanism of TNF-alpha and IL-6 by Group IIA Phospholipase A2
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Ahn JH, Park DW, Kim JH, Bae JJ, Bae YK, Park YK
- KMID: 2320216
- Yeungnam Univ J Med.
- 2004 Dec;21(2):177-190.
BACKGROUND: Secretory phospholipase A2 (sPLA2) are a group of extracellular enzymes that release fatty acids at the sn-2 position of phospholipids. Group IIA sPLA2 (sPLA2-IIA) has been detected in the... -
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- Role of phospholipase A2 in oxidant-induced alteration in phosphate transport in primary cultured rabbit renal proximal tubule cells
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Park KM, Ko SH, Woo JS, Jung JS, Lee SH, Kim YK
- KMID: 2071540
- Korean J Physiol Pharmacol.
- 1998 Oct;2(5):601-609.
The present study was undertaken to examine the role of phospholipase A2 (PLA2) in oxidant-induced inhibition of phosphate transport in primary cultured rabbit renal proximal tubule cells. Uptakes of phosphate and glucose were... -
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- Role of the PLA2-Activated Neutrophilic Oxidative Stress in Oleic Acid-Induced Acute Lung Injury
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Lee YM, Kim BY, Park YY
- KMID: 2050585
- Tuberc Respir Dis.
- 2010 Feb;68(2):55-61.
- doi: 10.4046/trd.2010.68.2.55
BACKGROUND: The underlying pathogenesis of fat embolism-induced acute lung injury (ALI) has not been elucidated. In the present study, the pathogenesis of fat embolism-induced ALI was probed in association with... -
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- The Signaling Pathway of G-protein Rac and Eicosanoid Synthesis by Titanium Particles
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Lee SS, Her JY, Woo CH, Kim JH, Chang JD
- KMID: 2105760
- J Korean Orthop Assoc.
- 2001 Aug;36(4):317-325.
PURPOSE: In order to understand the intracellular signaling pathway involving the c-fos gene expression that is caused by Titanium-particles, we analyzed the involvement of Rac, cytosolic phospholipase A2, and eicosanoids... -
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- Cromakalim blocks membrane phosphoinositide activated signals in the guinea pig lung mast cells stimulated with antigen-antibody reactions
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Ro JY, Kim JY, Kim KH
- KMID: 1562328
- Korean J Physiol Pharmacol.
- 1998 Apr;2(2):251-260.
Cromakalim (BRL 34915), known as an airway smooth muscle relaxant, inhibited the releases of mediators in the antigen-induced mast cell activation. It has been suggested that cromakalim, in part, inhibited mediator releases by... -
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- Role of phospholipase A2 in hypoxia-induced renal cell injury
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Choi WR, Ko SH, Cho SI, Woo JS, Jung JS, Lee SH, Kim YK
- KMID: 1917075
- Korean J Physiol Pharmacol.
- 1999 Feb;3(1):93-100.
The present study was designed to assess the roles of PLA2 activation and arachidonic acid (AA) metabolites in hypoxia-induced renal cell injury. Hypoxia increased LDH release in a dose-dependent manner in rabbit renal... -
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- Phospholipase A2 as an Index of Disease Activity in Rheumatoid Arthritis
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Oh DH, Choe JY, Song YH, Shon HS, Chang SG, Kim SG, Lee JM, Kim NS, Chang HW
- KMID: 2202520
- J Korean Rheum Assoc.
- 1999 Jun;6(2):135-142.
OBJECTIVES: A limited retrospective study of patients with rheumatoid arthritis (RA) found that serum phospholipase A2 (PLA2) activity correlates with disease activity. To assess the strength of this relationship we... -
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- Changes in the Activity and Expression of Cytosolic Pospholipase A2 in Human Amnion at Parturition
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Han GS, Lee YK, Park YK
- KMID: 2261405
- Korean J Obstet Gynecol.
- 1999 Jun;42(6):1278-1285.
OBJECTIVE: Cytosolic phospholipase A2 [cPLA2 exhibits preference for arachidonic acid in the sn-2 phospholipid, and it may play a role in agonist-stimulated signal transduction pathways involving prostaglandin synthesis. The purpose... -
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- Moxifloxacin Ameliorates Oleic Acid-induced Acute Lung Injury by Modulation of Neutrophilic Oxidative Stress in Rats
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Kim BY, Lee YM
- KMID: 1458042
- Tuberc Respir Dis.
- 2010 Jun;68(6):334-344.
- doi: 10.4046/trd.2010.68.6.334
BACKGROUND: Based on the known immunoregulatory functions of moxifloxacin on phagocytes, the therapeutic effect of moxifloxacin on oleic acid (OA)-induced acute lung injury (ALI) was investigated. METHODS: Moxifloxacin (10 mg/kg) was... -
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