- The Pharmacokinetics, Acute Biological Effects and Safety of Recombinant Human Growth Hormones
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Seo JJ
- KMID: 1683518
- J Korean Pediatr Soc.
- 1990 Aug;33(8):1104-1110.
No abstract available. -
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- The pharmacokinetics and biological effects of yeast derived recombinant methionyl growth hormone in growth hormone deficient children
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Lee BC
- KMID: 1691326
- J Korean Pediatr Soc.
- 1992 Mar;35(3):349-354.
No abstract available. -
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- Pharmacokinetics of vacor
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Kang CM, Lee TH, Lee KY, Lee MH
- KMID: 1688695
- Chonnam Med J.
- 1993 Jun;30(1):25-33.
No abstract available. -
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- Pharmacokinetics and drug therapy in neonates
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Cho HJ
- KMID: 2385909
- Pediatr Emerg Med J.
- 2017 Jun;4(1):5-11.
- doi: 10.22470/pemj.2017.00059
Neonates include both full term and preterm infants up to 28 days of age. The heterogeneity and rapid physiologic change of neonates affect all aspects of pharmacokinetics such as absorption,... -
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- Current Updates in Pharmacokinetics and Pharmacodynamics of Fluoroquinolones
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Ko YH, Song PH
- KMID: 1839381
- Korean J Urogenit Tract Infect Inflamm.
- 2015 Apr;10(1):1-6.
- doi: 10.14777/kjutii.2015.10.1.1
The ultimate goal of antimicrobial treatment is to decrease the morbidity and mortality related to infection. Maximizing these outcomes requires an understanding of the complex interactions between the drug administered,... -
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- Population pharmacokinetics and bayesian feedback method for nortriptyline dosage optimisation
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Shin SG, Woo JI, Jang IJ, Park CW, Kim JJ, Hong JP, Lee KH
- KMID: 2197830
- J Korean Neuropsychiatr Assoc.
- 1992 Sep;31(5):884-894.
No abstract available. -
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- Effect of hemodialysis and continuous ambulatory peritoneal dialysis on pharmacokinetics of carumonam
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Yim DS, Shin SG, Cho JT, Han JS, Lee KH, Jang IJ
- KMID: 1694610
- Korean J Nephrol.
- 1993 Mar;12(1):27-35.
No abstract available. -
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- "Physiological spaces and multicompartmental pharmacokinetic models": Fundamentals that pharmacokinetics textbooks do not tell you
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Yim DS
- KMID: 2351804
- Transl Clin Pharmacol.
- 2015 Dec;23(2):35-37.
- doi: 10.12793/tcp.2015.23.2.35
No abstract available. -
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- Role of the ABCB1 Drug Transporter Polymorphisms in the Pharmacokinetics of Oseltamivir in Humans: a Preliminary Report
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Cha YJ, Ghim JL
- KMID: 2385963
- J Korean Med Sci.
- 2017 Sep;32(9):1542-1547.
- doi: 10.3346/jkms.2017.32.9.1542
Oseltamivir is a substrate of P-glycoprotein, an efflux drug transporter encoded by ABCB1. The objective of this study was to assess the role of ABCB1 (c.1236C>T, c.2677G>T/A, and c.3435C>T) polymorphisms... -
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- Understanding the pharmacokinetics of prodrug and metabolite
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Cho S, Yoon YR
- KMID: 2420300
- Transl Clin Pharmacol.
- 2018 Mar;26(1):1-5.
- doi: 0.12793/tcp.2018.26.1.1
This tutorial explains the pharmacokinetics of a prodrug and its active metabolite (or parent drug) using a two-step, consecutive, first-order irreversible reaction as a basic model for prodrug metabolism. In... -
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- Elucidation of the pathophysiology of intradialytic muscle cramps: pharmacokinetics applied to translational research
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Atkinson A
- KMID: 2467964
- Transl Clin Pharmacol.
- 2019 Dec;27(4):119-122.
- doi: 10.12793/tcp.2019.27.4.119
In the conventional concept of translational research, investigations flow from the laboratory bench to the bedside. However, clinical research can also serve as the starting point for subsequent laboratory investigations... -
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- Development of a user-friendly training software for pharmacokinetic concepts and models
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Han S, Lim B, Lee H, Bae SH
- KMID: 2429512
- Transl Clin Pharmacol.
- 2018 Dec;26(4):166-171.
- doi: 10.12793/tcp.2018.26.4.166
Although there are many commercially available training software programs for pharmacokinetics, they lack flexibility and convenience. In this study, we develop simulation software to facilitate pharmacokinetics education. General formulas for... -
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- Understanding the pharmacokinetics of reversible metabolism
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Cho S, Yoon YR
- KMID: 2457571
- Transl Clin Pharmacol.
- 2019 Jun;27(2):52-58.
- doi: 10.12793/tcp.2019.27.2.52
This tutorial introduces the mathematical skills required to obtain exact and approximate solutions for reversible reactions and provides graphical insights to help understand the pharmacokinetics of reversible metabolism. The matrix... -
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- How to design intravenous anesthetic dose regimens based on pharmacokinetics and pharmacodynamics principles
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Park JC
- KMID: 2148006
- Anesth Pain Med.
- 2015 Oct;10(4):235-244.
- doi: 10.17085/apm.2015.10.4.235
Pharmacokinetics is the study of the rate and degree of drug transport to various tissues in the human body. Pharmacokinetic parameters summarize drug kinetics and ideally predict a clinical situation.... -
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- Pharmacokinetics of High-dose Intravenous Melphalan in Patients Undergoing Autologous Stem Cell Transplantation
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Lee SY, Kim JA, Lee JW, Koo HJ, Kim HK
- KMID: 2083509
- Korean J Hematol.
- 2007 Jun;42(2):122-128.
- doi: 10.5045/kjh.2007.42.2.122
BACKGROUND: Melphalan is frequently used in conditioning regimens prior to autologous stem cell transplantation. The pharmacokinetics of melphalan have shown great interindividual variations. This study aims to investigate the pharmacokinetics... -
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- Physiological spaces and multicompartmental pharmacokinetic models
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Atkinson A
- KMID: 2351805
- Transl Clin Pharmacol.
- 2015 Dec;23(2):38-41.
- doi: 10.12793/tcp.2015.23.2.38
The idea of body compartments has its origins in physiology and antedates their use in both physiologically-based predictive pharmacokinetic models and in the simpler compartmental models used to analyze pharmacokinetic... -
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- Pharmacokinetics and dosage regimen of ceftriaxone in E. coli lipopolysaccharide induced fever in buffalo calves
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Dardi MS, Sharma SK, Srivastava AK
- KMID: 1114856
- J Vet Sci.
- 2005 Jun;6(2):147-150.
The present study was planned to investigate the pharmacokinetics of ceftriaxone in experimentally induced febrile buffalo calves (n = 5). The fever was induced by intravenous injection of E.coli lipopolysaccaride... -
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- Experience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures
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Shin JW, Jung YS, Park K, Lee SM, Eun HS, Park MS, Park KI, Namgung R
- KMID: 2371378
- Korean J Pediatr.
- 2017 Feb;60(2):50-54.
- doi: 10.3345/kjp.2017.60.2.50
PURPOSE: The aims of this study were to evaluate the safety and pharmacokinetics of levetiracetam (LEV) in neonates with seizures and to establish a population pharmacokinetics (PPK) model by using... -
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- Effects of CYP1A enzyme specific inhibitor on pharmacokinetics of para-acetaminophen in Bactrian camel
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San R, Yue W, Hasi S
- KMID: 2448701
- J Vet Sci.
- 2019 May;20(3):e12.
- doi: 10.4142/jvs.2019.20.e12
The effects of CYP1A enzyme on the pharmacokinetics of p-acetaminophen were studied in Bactrian camel. Twelve Bactrian camels were divided into 2 groups, then given a single dose of p-acetaminophen... -
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- CYP3A5*3 Polymorphism and Its Clinical Implications and Pharmacokinetic Role
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Park JY, Cha YJ, Kim KA
- KMID: 2317850
- Transl Clin Pharmacol.
- 2014 Jun;22(1):3-7.
The cytochrome P450 (CYP) 3A subfamily is estimated to participate in the biotransformation of 50% of the currently prescribed drugs. Four members of the CYP3A subfamily have been identified in... -
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