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Screening of Peptide Libraries to Investigate the Substrate Specificity of UL97 Protein Kinase from Human Cytomegalovirus

Baek MC

Human cytomegalovirus encodes an unusual protein kinase UL97 which can phosphorylate exogenous substrates, including histone H2B and nucleoside analogs such as ganciclovir. The previous result interestingly showed that the peptides...
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The Safety Evaluation of a Potent Angiogenic Activator, Synthetic Peptide (SFKLRY-NH2) for the Skin Application

Kim DH, Lim YY, Kim HM, Kim SY, Kim BJ, Park SG, Lee T, Cho SM

  • KMID: 2052551
  • Toxicol Res.
  • 2012 Mar;28(1):51-56.
A novel synthetic hexapeptide (SFKLRY-NH2) that displays angiogenic activity has been identified by positional scanning of a synthetic peptide combinatorial library (PS-SPCL). This study was carried out to investigate the...
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Identification of Antimicrobial Peptide Hexamers against Oral Pathogens through Rapid Screening of a Synthetic Combinatorial Peptide Library

Song JS, Cho KJ, Kim J, Kim JH

A positional scanning synthetic peptide combinatorial library (PS-SCL) was screened in order to identify antimicrobial peptides against the cariogenic oral bacteria, Streptococcus mutans. Activity against Streptococcus gordonii and Aggregatibacter actinomycetemcomitans...
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Definition of the peptide mimotope of cellular receptor for hepatitis C virus E2 protein using random peptide library

Lee IH, Paik JE, Seol SY, Seog DH, Park SG, choi IH

BACKGROUND: Hepatitis C virus(HCV), a family of Flaviviridae, has a host cell-derived envelope containing a positive-stranded RNA genome, and has been known as the maj or etiological agent for chronic...
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A Phage Display-Identified Peptide Selectively Binds to Kidney Injury Molecule-1 (KIM-1) and Detects KIM-1–Overexpressing Tumors In Vivo

Haque ME, Khan F, Chi L, Gurung S, Vadevoo SM, Park RW, Kim DK, Kim SK, Lee B

PURPOSE: This study was carried out to identify a peptide that selectively binds to kidney injury molecule-1 (KIM-1) by screening a phage-displayed peptide library and to use the peptide for...
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Identification of high-affinity VEGFR3-binding peptides through a phage-displayed random peptide library

Shi LF, Wu Y, Li CY

OBJECTIVE: Vascular endothelial growth factor (VEGF) interaction with its receptor, VEGFR-3/Flt-4, regulates lymphangiogenesis. VEGFR-3/Flt-4 expression in cancer cells has been correlated with clinical stage, lymph node metastasis, and lymphatic invasion....
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Characterization of two antimicrobial peptides identified from a random peptide library and expressed in the methylotrophic yeast pichia pastoris

Jeon IS, Song KD, Oh JD, Choi JK

  • KMID: 1703518
  • J Biomed Res.
  • 2013 Dec;14(4):235-239.
Antimicrobial peptides (AMPs) are an important component of innate defense mechanisms with broad-spectrum activities against various pathogenic microorganisms, including Gram-positive and Gram-negative bacteria, fungi, and viruses. Antibiotic resistance has become...
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Stimulation of Bactericidal and Fungicidal Activity of Neonatal Monocytes by Immunoactivating Peptide

Ju SA, Kim CK, Kim BS, Seo SK, Ha TY, Park SJ, Park SK

  • KMID: 1838656
  • J Korean Soc Neonatol.
  • 2001 May;8(1):18-24.
PURPOSE: To evaluate the function of Trp-Lys-Tyr-Met-Val-D-Met (WKYMVm) in human neonatal monocytes. METHODS: The peptide, Trp-Lys-Tyr-Met-Val-D-Met (WKYMVm), was synthesized, purified, and prepared in the Peptide Library Support Facility at Pohang...
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Serotype- and serogroup-specific detection of African horsesickness virus using phage displayed chicken scFvs for indirect double antibody sandwich ELISAs

van Wyngaardt W, Mashau C, Wright I, Fehrsen J

There is an ongoing need for standardized, easily renewable immunoreagents for detecting African horsesickness virus (AHSV). Two phage displayed single-chain variable fragment (scFv) antibodies, selected from a semi-synthetic chicken antibody...
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Human Monoclonal Antibody Inhibiting Reverse Transcriptase Activity of Hepatitis B Virus Polymerase Protein

Park SJ, Seol SY, Jee SR, Park ET, Lee YJ, Lee SH, Chung JM, Cho HD, Jeong YJ, Choi IH, Park SG

  • KMID: 935184
  • Korean J Gastroenterol.
  • 2007 Feb;49(2):85-92.
BACKGROUND/AIMS: To develop a novel treatment method for hepatitis B virus (HBV) infection, we aimed to make a human monoclonal antibody inhibiting reverse transcriptase (RT) activity of P protein which...
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