- Angiogenesis and Mineralization During Distraction Osteogenesis
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Choi IH, Chung CY, Cho TJ, Yoo WJ
- KMID: 1109748
- J Korean Med Sci.
- 2002 Aug;17(4):435-447.
- doi: 10.3346/jkms.2002.17.4.435
Distraction osteogenesis is currently a standard method of bone lengthening. It is a viable method for the treatment of short extremities as well as extensive bone defects, because large amounts... -
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- Proangiogenic cells enhanced persistent and physiologic neovascularization compared with macrophages
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Choi YE, Cha YR, Lee KM, Kim HJ, Yoon CH
- KMID: 2155440
- Exp Mol Med.
- 2015 Sep;47(9):e186.
- doi: 10.1038/emm.2015.60
Proangiogenic cells (PACs) display surface markers and secrete angiogenic factors similar to those used by myelomonocytic cells, but, unlike myelomonocytic cells, PACs enhance neovascularization activity in experimental ischemic diseases. This... -
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- Tie2 is tied at the cell-cell contacts and to extracellular matrix by Angiopoietin-1
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Fukuhara S, Sako K, Noda K, Nagao K, Miura K, Mochizuki
- KMID: 1123460
- Exp Mol Med.
- 2009 Mar;41(3):133-139.
- doi: 10.3858/emm.2009.41.3.016
Angiopoietin-1 (Ang1) binds to and activates Tie2 receptor tyrosine kinase. Ang1-Tie2 signal has been proposed to exhibit two opposite roles in the controlling blood vessels. One is vascular stabilization and... -
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- The discovery of placenta growth factor and its biological activity
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De Falco S
- KMID: 1120136
- Exp Mol Med.
- 2012 Jan;44(1):1-9.
- doi: 10.3858/emm.2012.44.1.025
Angiogenesis is a complex biological phenomenon crucial for a correct embryonic development and for post-natal growth. In adult life, it is a tightly regulated process confined to the uterus and... -
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- Effect of Basic Fibroblast Growth Factor-Saporin (bFGF-SAP) Conjugate on Bovine Choriocapillary Endothelial Cells
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Kim YH, Kim HS, Yoo JS
- KMID: 754377
- Korean J Ophthalmol.
- 2004 Dec;18(2):121-131.
- doi: 10.3341/kjo.2004.18.2.121
We evaluated the effect of a basic fibroblast growth factor (bFGF) and saporin conjugate (bFGF-SAP) on proliferation, migration and tubule formation in bovine choriocapillary endothelial cells (BCECs). Cell proliferation and... -
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- Antiangiogenesis therapy: an update after the first decade
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De Falco S
- KMID: 1792005
- Korean J Intern Med.
- 2014 Jan;29(1):1-11.
- doi: 10.3904/kjim.2014.29.1.1
Angiogenesis is a complex biological phenomenon that forms new blood vessels from the pre-existing vasculature. Aberrant angiogenesis has been implicated in a variety of diseases such as cancer, atherosclerosis, arthritis,... -
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- VEGF-VEGFR Signals in Health and Disease
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Shibuya M
- KMID: 2048324
- Biomol Ther.
- 2014 Jan;22(1):1-9.
Vascular endothelial growth factor (VEGF)-VEGF receptor (VEGFR) system has been shown to play central roles not only in physiological angiogenesis, but also in pathological angiogenesis in diseases such as cancer.... -
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- Early growth response protein 1 acts as an activator of SOX18 promoter
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Petrovic I, Kovacevic-Grujicic N, Stevanovic M
- KMID: 983986
- Exp Mol Med.
- 2010 Feb;42(2):132-142.
- doi: 10.3858/emm.2010.42.2.015
Sex-determining region Y box 18 (Sox18/SOX18) gene is an important regulator of vascular development playing a role in endothelial cell specification or differentiation, angiogenesis and atherogenesis. The aim of this... -
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- Biomedical significance of endothelial cell specific growth factor, angiopoietin
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Koh GY, Kim I, Kwak HJ, Yun MJ, Leem JC
- KMID: 1093591
- Exp Mol Med.
- 2002 Mar;34(1):1-11.
Until recently, vascular endothelial growth factor (VEGF) was the only growth factor proven to be specific and critical for blood vessel formation. Other long-known factors, such as the fibroblast growth... -
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- Effect of Endogenous Bone Marrow Derived Stem Cells Induced by AMD-3100 on Expanded Ischemic Flap
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Jeong HS, Lee HK, Tark KC, Lew DH, Koh YW, Kim CH, Seo IS
- KMID: 2151419
- J Korean Med Sci.
- 2014 Nov;29(Suppl 3):S237-S248.
- doi: 10.3346/jkms.2014.29.S3.S237
The purpose of this study was to devise an expanded ischemic flap model and to investigate the role of AMD-3100 (Plerixafor, chemokine receptor 4 inhibitor) in this model by confirming... -
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- Mesenchymal Stem Cells Improve Wound Healing In Vivo via Early Activation of Matrix Metalloproteinase-9 and Vascular Endothelial Growth Factor
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Kim CH, Lee JH, Won JH, Cho MK
- KMID: 1785956
- J Korean Med Sci.
- 2011 Jun;26(6):726-733.
- doi: 10.3346/jkms.2011.26.6.726
We investigated the effects of mesenchymal stem cells (MSCs) on wound healing using a three-dimensional (3D) collagen gel scaffold. Three circular full-thickness skin defects were created on the back of... -
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- Inhibition of trichostatin A-induced antiangiogenesis by small-interfering RNA for thrombospondin-1
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Kang JH, Kim SA, Chang SY, Hong S, Hong KJ
- KMID: 1047092
- Exp Mol Med.
- 2007 Jun;39(3):402-411.
Expression of thrombospondin-1 (TSP-1), which is a known inhibitor of tumor growth and angiogenesis, is reciprocally regulated by positive regulators, such as VEGF. Additionally, trichostatin A (TSA) suppresses tumor progression... -
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- Development of an angiogenesis-focused cDNA chip and validation of its functionality
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Shim JS, Lee HK, Park HM, Kim JO, Kim EK, Hwang KH, Kim KT, Park SW, Lee JH, Kwon HJ
- KMID: 1093471
- Exp Mol Med.
- 2005 Aug;37(4):365-370.
DNA chip has been used as a powerful tool to study the genetic reprogramming of cells and its link to cellular phenotype such as angiogenesis. To evaluate the angiogenesis related... -
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- Targeted Molecular Imaging
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Kim EE
- KMID: 1111248
- Korean J Radiol.
- 2003 Dec;4(4):201-210.
- doi: 10.3348/kjr.2003.4.4.201
Molecular imaging aims to visualize the cellular and molecular processes occurring in living tissues, and for the imaging of specific molecules in vivo, the development of reporter probes and dedicated... -
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- KR-31831, a new synthetic anti-ischemic agent, inhibits in vivo and in vitro angiogenesis
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Yi EY, Park SY, Song HS, Son MJ, Yi KY, Yoo SE, Kim YJ
- KMID: 1098084
- Exp Mol Med.
- 2006 Oct;38(5):502-508.
Angiogenesis is considered to be an integral process to the growth and spread of solid tumors. Anti-angiogenesis therapy recently has been found to be one of the most promising anti-cancer... -
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- Cryptotanshinone but not tanshinone IIA inhibits angiogenesisin vitro
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Hur JM, Shim JS, Jung HJ, Kwon HJ
- KMID: 755752
- Exp Mol Med.
- 2005 Apr;37(2):133-137.
In the course of screening of angiogenesis inhibitor from natural products, cryptotanshinone from Salvia miltiorrhiza was isolated as a potent small molecule inhibitor of angiogenesis. Cryptotanshinone inhibits bFGF-induced angiogenesis of... -
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- Effect of Basic Fibroblast Growth Factor on Fibrovascular Ingrowth into Porous Polyethylene Anophthalmic Socket Implants
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Park WC, Han SK, Kim NJ, Chung TY, Khwarg SI
- KMID: 1099078
- Korean J Ophthalmol.
- 2005 Mar;19(1):1-8.
- doi: 10.3341/kjo.2005.19.1.1
To investigate the effect of basic Fibroblast Growth Factor (bFGF) on fibrovascular ingrowth into porous polyethylene orbital implants (Medpor (R) ) and to investigate any differences according to the method... -
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- A serum-stable branched dimeric anti-VEGF peptide blocks tumor growth via anti-angiogenic activity
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Kim JW, Kim TD, Hong BS, Kim OY, Yoon WH, Chae CB, Gho YS
- KMID: 1104211
- Exp Mol Med.
- 2010 Jul;42(7):514-523.
- doi: 10.3858/emm.2010.42.7.052
Angiogenesis is critical and indispensable for tumor progression. Since VEGF is known to play a central role in angiogenesis, the disruption of VEGF-VEGF receptor system is a promising target for... -
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- Fibrovascularization of Intraorbital Hydroxyapatite-Coated Alumina Sphere in Rabbits
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Chung WS, Song SJ, Lee SH, Kim EA
- KMID: 1099079
- Korean J Ophthalmol.
- 2005 Mar;19(1):9-17.
- doi: 10.3341/kjo.2005.19.1.9
We investigated the fibrovascular ingrowth and fibrovascular tissue maturation of hydroxyapatite-coated, porous alumina sphere (Alumina sphere) in comparison with the hydroxyapatite sphere (HAp sphere) in rabbits. Alumina spheres and HAp... -
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- c-Jun N-terminal kinase is involved in motility of endothelial cell
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Shin EY, Kim SY, Kim EG
- KMID: 1457542
- Exp Mol Med.
- 2001 Dec;33(4):276-283.
Cell motility is essential for a wide range of cellular activities including anigogenesis as well as metastasis of tumor cells. Ras has been implicated in cell migration and invasion, and... -
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