- Cancer Stem Cells in Brain Tumors and Their Lineage Hierarchy
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Kong DS
- KMID: 1426152
- Int J Stem Cells.
- 2012 May;5(1):12-15.
Despite recent advances in the development of novel targeted chemotherapies, the prognosis of malignant glioma remains dismal. The chemo-resistance of this tumor is attributed to tumor heterogeneity. To explain this... -
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- New Findings on Breast Cancer Stem Cells: A Review
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Bozorgi A, Khazaei M, Khazaei MR
- KMID: 2176278
- J Breast Cancer.
- 2015 Dec;18(4):303-312.
- doi: 10.4048/jbc.2015.18.4.303
Since the introduction of the "cancer stem cell" theory, significant developments have been made in the understanding of cancer and the heterogenic structure of tumors. In 2003, with the isolation... -
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- Expression of CD133, CD44, CK7, and OCT4 in Animal Cancers
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Park JH, Cho ES, Ryu SY, Jung JY, Son HY
- KMID: 1991779
- Korean J Vet Res.
- 2013 Jun;53(2):109-115.
Cancers are mainly sustained by a small pool of neoplastic cells, known as cancer stem cells or tumor-initiating cells. These cells possess the ability to self-renew and proliferate, and are... -
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- Cellular origin of liver cancer stem cells
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Eun JR
- KMID: 2138634
- Yeungnam Univ J Med.
- 2015 Jun;32(1):1-7.
- doi: 10.12701/yujm.2015.32.1.1
Over several decades, a hierarchical cancer stem cell (CSC) model has been established in development of solid cancers, including hepatocellular carcinoma(HCC). In terms of this concept, HCCs originate from liver... -
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- Reactive Oxygen Species and Cancer
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Choi I
- KMID: 2168243
- Hanyang Med Rev.
- 2013 May;33(2):118-122.
- doi: 10.7599/hmr.2013.33.2.118
Reactive Oxygen Species (ROS) are a class of signaling molecules that regulate intracellular signaling cascades in response to external stimuli. Once accumulated in cells, they can damage DNA modifying gene... -
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- Cancer Stem Cells: Biological Features and Targeted Therapeutics
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Song SY, Seo D
- KMID: 2129479
- Hanyang Med Rev.
- 2015 Nov;35(4):250-257.
- doi: 10.7599/hmr.2015.35.4.250
Advance in stem cells (SCs) has become significant by the isolation of the tissue-specific SCs in a tissue, because it is the beginning of using SC utility for regenerative medicine.... -
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- Breast Stem Cells
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Choi D, Clarke RB, Lee MH
- KMID: 2173522
- J Korean Breast Cancer Soc.
- 2004 Mar;7(1):1-7.
- doi: 10.4048/jkbcs.2004.7.1.1
Mammary gland development and function would not be possible without tissue-specific stem cells. The mammalian reproductive cycles of pregnancy-associated proliferation, lactational differentiation, apoptosis and remodelling following weaning may occur many... -
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- Cancer Stem Cells
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Hur MH, Dontu G, Wicha MS
- KMID: 2175033
- J Breast Cancer.
- 2007 Sep;10(3):173-179.
- doi: 10.4048/jbc.2007.10.3.173
Recent results have supported the cancer stem cells hypothesis in which tumors originate from tissue stem cells or their early progenitors and, as a result, produce tumors that retain stem... -
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- Gastric stem cells and gastric cancer stem cells
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Han ME, Oh SO
- KMID: 2046753
- Anat Cell Biol.
- 2013 Mar;46(1):8-18.
- doi: 10.5115/acb.2013.46.1.8
The gastric epithelium is continuously regenerated by gastric stem cells, which give rise to various kinds of daughter cells, including parietal cells, chief cells, surface mucous cells, mucous neck cells,... -
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- Invited Commentary on: Can CD44+/CD24- Tumor Stem Cells Be Used to Determine the Extent of Breast Cancer Invasion Following Neoadjuvant Chemotherapy?
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Lee JE, Nam SJ
- KMID: 2394782
- J Breast Cancer.
- 2011 Sep;14(3):251-252.
No abstract available. -
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- Application of Nanotechnology in Targeting of Cancer Stem Cells: A Review
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Asghari F, Khademi R, Ranjbar FE, Malekshahi ZV, Majidi RF
- KMID: 2465894
- Int J Stem Cells.
- 2019 Jul;12(2):227-239.
- doi: 10.15283/ijsc19006
Cancer is increasingly apparent as a systems-level, network happening. The central tendency of malignant alteration can be described as a two-phase procedure, where an initial increase of network plasticity is... -
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- Cancer Stem Cells in Head and Neck Cancer
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Joo YH
- KMID: 2277909
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2014 Jul;57(7):427-432.
- doi: 10.3342/kjorl-hns.2014.57.7.427
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Despite advances in therapy, which have improved the quality of life, survival rates have remained static... -
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- Role of Gastric Stem Cells in Gastric Carcinogenesis by Chronic Helicobacter pylori Infection
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Park MI, Heo J
- KMID: 2046330
- Korean J Helicobacter Up Gastrointest Res.
- 2015 Sep;15(3):155-159.
- doi: 10.7704/kjhugr.2015.15.3.155
Gastric cancer is a disease with the second cancer-related mortality in the world. Helicobacter pylori infection that is one of major causes of gastric carcinogenesis induces a chronic inflammation in... -
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- Transitional Cell Tumor Culture and Chemosensitivity Test: Preliminary Report
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Choi NG, Lee KM
- KMID: 1912778
- Korean J Urol.
- 1989 Feb;30(1):1-6.
Usually, tumor stem cells have been assessed functionally in animals with various in vivo transplantation assays or with in vitro colony forming assays. Such studies indicate the tumor stem cell... -
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- Cancer stem cell theory and update in oral squamous cell carcinoma
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Kim DH, Yun JY, Lee JH, Myoung H, Kim SM
- KMID: 2136998
- J Korean Assoc Oral Maxillofac Surg.
- 2011 Apr;37(2):97-108.
- doi: 10.5125/jkaoms.2011.37.2.97
Cancer stem cells have stem cell-like features, such as the ability for self-renewal and differentiation but show unlimited growth because they have the lost normal regulation of cell growth. Cancer... -
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- OCT4 Expression Enhances Features of Cancer Stem Cells in a Mouse Model of Breast Cancer
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Kim RJ, Nam JS
- KMID: 2053664
- Lab Anim Res.
- 2011 Jun;27(2):147-152.
- doi: 10.5625/lar.2011.27.2.147
The cancer stem cell (CSC) hypothesis proposes that CSCs are responsible for metastasis and disease recurrence. Therefore, targeting CSCs has the potential to significantly improve outcomes for cancer patients. The... -
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- MicroRNAs in Human Embryonic and Cancer Stem Cells
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Navarro A, Monzo M
- KMID: 1071411
- Yonsei Med J.
- 2010 Sep;51(5):622-632.
- doi: 10.3349/ymj.2010.51.5.622
MicroRNAs (miRNAs) are small non-coding RNAs that regulate messenger RNAs at the post-transcriptional level. They play an important role in the control of cell physiological functions, and their alterations have... -
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- Tumorsphere formation and cancer stem cell characterization of REM134 canine mammary carcinoma cells
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Byeon JS, Lee J, Jeong DU, Gu NY, Cho IS, Cha SH
- KMID: 2437695
- Korean J Vet Res.
- 2018 Dec;58(4):201-209.
- doi: 10.14405/kjvr.2018.58.4.201
Canine mammary tumors are among the most frequently observed cutaneous tumors in female dogs. Cancer stem cells (CSCs), referred to as tumor-initiating cells, are thought to have properties similar to... -
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- The Role of Notch1 Signaling in Anaplastic Thyroid Carcinoma
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Kim HJ, Kim MJ, Kim A, Jung CW, Park S, Koh JS, Myung JK
- KMID: 2378124
- Cancer Res Treat.
- 2017 Apr;49(2):509-517.
- doi: 10.4143/crt.2016.214
PURPOSE: The Notch signaling pathway is widely expressed in normal, reactive, and neoplastic tissues; however, its role in thyroid tissues has not been fully elucidated. Therefore, this study was conducted... -
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- Characterization of sphere-forming HCT116 clones by whole RNA sequencing
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Chung E, Oh I, Lee KY
- KMID: 2160947
- Ann Surg Treat Res.
- 2016 Apr;90(4):183-193.
- doi: 10.4174/astr.2016.90.4.183
PURPOSE: To determine CD133+ cells defined as cancer stem cells (CSCs) in colon cancer, we examined whether CD133+ clones in HCT116 demonstrate known features of CSCs like sphere-forming ability, chemodrug-resistance,... -
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