- 4′-O-β-D-Glucosyl-5-O-Methylvisamminol Attenuates Pro-Inflammatory Responses and Protects against Oxidative Damages
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Yoo OK, Keum YS
- KMID: 2455093
- Biomol Ther.
- 2019 Jul;27(4):381-385.
- doi: 10.4062/biomolther.2018.232
We attempted to examine anti-inflammatory and anti-oxidant effects of 4′-O-β-D-glucosyl-5-O-methylvisamminol (GOMV), the first epigenetic inhibitor of histone phosphorylation at Ser10. While GOMV did not affect the viability of murine macrophage... -
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- Luteolin and luteolin-7-O-glucoside protect against acute liver injury through regulation of inflammatory mediators and antioxidative enzymes in GalN/LPS-induced hepatitic ICR mice
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Park CM, Song YS
- KMID: 2464126
- Nutr Res Pract.
- 2019 Dec;13(6):473-479.
- doi: 10.4162/nrp.2019.13.6.473
BACKGROUND/OBJECTIVES: Anti-inflammatory and antioxidative activities of luteolin and luteolin-7-O-glucoside were compared in galactosamine (GalN)/lipopolysaccharide (LPS)-induced hepatitic ICR mice. MATERIALS/METHODS: Male ICR mice (6 weeks old) were divided into 4 groups: normal... -
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- Dysregulation of NRF2 in Cancer: from Molecular Mechanisms to Therapeutic Opportunities
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Jung BJ, Yoo HS, Shin S, Park YJ, Jeon SM
- KMID: 2400815
- Biomol Ther.
- 2018 Jan;26(1):57-68.
- doi: 10.4062/biomolther.2017.195
Nuclear factor E2-related factor 2 (NRF2) plays an important role in redox metabolism and antioxidant defense. Under normal conditions, NRF2 proteins are maintained at very low levels because of their... -
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- Diabetic Cardiomyopathy and Its Prevention by Nrf2: Current Status
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Chen J, Zhang Z, Cai L
- KMID: 2280677
- Diabetes Metab J.
- 2014 Oct;38(5):337-345.
- doi: 10.4093/dmj.2014.38.5.337
Diabetic cardiomyopathy (DCM), as one of the major cardiac complications in diabetic patients, is known to related with oxidative stress that is due to a severe imbalance between reactive oxygen... -
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- Involvement of NRF2 Signaling in Doxorubicin Resistance of Cancer Stem Cell-Enriched Colonospheres
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Ryoo IG, Kim G, Choi BH, Lee SH, Kwak MK
- KMID: 2351671
- Biomol Ther.
- 2016 Sep;24(5):482-488.
- doi: 10.4062/biomolther.2016.145
Cancer stem cells (CSCs) are a subset of tumor cells, which are characterized by resistance against chemotherapy and environmental stress, and are known to cause tumor relapse after therapy. A... -
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- Alteration of Nrf2 and p-Nrf2 Protein Expression in Hypokalemic Rat Kidney
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Cho HJ, Ahn KY
- KMID: 2283747
- Korean J Phys Anthropol.
- 2015 Mar;28(1):55-62.
- doi: 10.11637/kjpa.2015.28.1.55
Potassium (K) balance is regulated not only by ion channels and ion transporters, but also by various genes including NF-E2-related factor 2 (Nrf2). Although mRNA distribution and role of Nrf2... -
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- Age-Related Changes in Nuclear Factor Erythroid 2-Related Factor 2 and Reactive Oxygen Species and Mitochondrial Structure in the Tongues of Fischer 344 Rats
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Baek MK, Lee H, Kim KO, Kwon HJ, Chung MH, Park HM, Woo JH, Kim DY
- KMID: 2396792
- Clin Exp Otorhinolaryngol.
- 2017 Dec;10(4):357-362.
- doi: 10.21053/ceo.2016.01095
OBJECTIVES: Previously the authors reported age-related changes in the activities of anti-oxidative enzyme activities and protein expressions in the tongues of rats. Because more information is required about relations between... -
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- Age-related Changes in the Sirtuin1-NFE2-related Factor 2 Signaling System in the Kidney
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Bae MN, Choi MS, Eum SH, Kim EN, Lim JH, Kim MY, Ban TH, Jang IA, Yoon HE, Park CW, Chang YS, Choi BS
- KMID: 2376944
- Korean J Med.
- 2017 Feb;92(1):53-61.
- doi: 10.3904/kjm.2017.92.1.53
BACKGROUND/AIMS: Renal aging-related changes are characterized by oxidative stress. SIRT1 regulates cellular conditions by activating Nrf2. The present study investigated the processes of renal changes by antioxidant enzymes and the... -
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- Protective Effects of Ursolic Acid on Osteoblastic Differentiation via Activation of IER3/Nrf2
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Lee SI
- KMID: 2460998
- J Dent Hyg Sci.
- 2019 Sep;19(3):198-204.
- doi: 10.17135/jdhs.2019.19.3.198
BACKGROUND: Oxidative stress is a known to be associated with in the pathogenesis of many inflammatory diseases, including periodontitis. Ursolic acid is a pentacyclic triterpenoid with has antimicrobial, antioxidative, and... -
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- Alteration of Akt, p-Akt, ERK, and p-ERK Proteins Expression in the Kidney of Hypokalemic Rat
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Bae CS, Cho HJ, Ahn KY
- KMID: 2392274
- Korean J Phys Anthropol.
- 2017 Sep;30(3):87-98.
- doi: 10.11637/kjpa.2017.30.3.87
Hypokalemia causes metabolic alkalosis and morphological changes of the kidney. K⺠balance is regulated not only by ion channels or pump gene, but also by various genes including NF-E2-related factor... -
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- Expression of Nuclear Factor Erythroid 2 Protein in Malignant Cutaneous Tumors
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Choi CY, Kim JY, Wee SY, Lee JH, Nam DH, Kim CH, Cho MK, Lee YJ, Nam HS, Lee SH, Cho SW
- KMID: 2267614
- Arch Plast Surg.
- 2014 Nov;41(6):654-660.
- doi: 10.5999/aps.2014.41.6.654
BACKGROUND: Reactive oxygen species (ROS) damages cell molecules, and modifies cell signaling. The nuclear factor E2-related factor (Nrf2) is a critical transcription regulator, which protects cells against oxidative damage. Nrf2... -
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- Oxidative Damage and Nuclear Factor Erythroid 2-Related Factor 2 Protein Expression in Normal Skin and Keloid Tissue
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Lee YJ, Kwon SB, Kim CH, Cho HD, Nam HS, Lee SH, Lee MW, Nam DH, Choi CY, Cho MK
- KMID: 2171450
- Ann Dermatol.
- 2015 Oct;27(5):507-516.
- doi: 10.5021/ad.2015.27.5.507
BACKGROUND: Reactive oxygen species (ROS) play an important role in the induction of apoptosis under pathological conditions. Recently, a significant increase in ROS production and disrupted apoptosis mechanisms in keloids... -
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- Effect of Estradiol in an Azoxymethane/Dextran Sulfate Sodium-Treated Mouse Model of Colorectal Cancer: Implication for Sex Difference in Colorectal Cancer Development
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Son HJ, Sohn SH, Kim N, Lee HN, Lee SM, Nam RH, Park JH, Song CH, Shin E, Na HY, Kim JS, Lee DH, Surh YJ
- KMID: 2464410
- Cancer Res Treat.
- 2019 Apr;51(2):632-648.
- doi: 10.4143/crt.2018.060
PURPOSE: This study demonstrates that estradiol downregulates inflammation and inhibits colorectal cancer (CRC) development in azoxymethane/dextran sulfate sodium (AOM/DSS) mouse model. MATERIALS AND METHODS: AOM/DSS-treated male and female mice were sacrificed... -
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- Carbon Monoxide Ameliorates 6-Hydroxydopamine-Induced Cell Death in C6 Glioma Cells
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Moon H, Jang JH, Jang TC, Park GH
- KMID: 2429057
- Biomol Ther.
- 2018 Mar;26(2):175-181.
- doi: 10.4062/biomolther.2018.009
Carbon monoxide (CO) is well-known as toxic gas and intrinsic signaling molecule such as neurotransmitter and blood vessel relaxant. Recently, it has been reported that low concentration of CO exerts... -
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- Clinical significance of nuclear factor erythroid 2-related factor 2 in patients with chronic obstructive pulmonary disease
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Ban WH, Kang HH, Kim IK, Ha JH, Joo H, Lee JM, Lim JU, Lee SH, Rhee CK
- KMID: 2416001
- Korean J Intern Med.
- 2018 Jul;33(4):745-752.
- doi: 10.3904/kjim.2017.030
BACKGROUND/AIMS: Several studies have identified a role for nuclear factor erythroid 2-related factor 2 (Nrf2) in the development of chronic obstructive pulmonary disease (COPD). However, the relationship between the plasma... -
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- Nrf2-Heme oxygenase-1 modulates autophagy and inhibits apoptosis triggered by elevated glucose levels in renal tubule cells
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Kim JH, Kim KM, Jeong JU, Shin JH, Shin JM, Bang KT
- KMID: 2457723
- Kidney Res Clin Pract.
- 2019 Sep;38(3):318-325.
- doi: 10.23876/j.krcp.18.0152
BACKGROUND: Autophagy is a highly balanced process in which lysosomes remove aged and damaged organelles and cellular proteins. Autophagy is essential to maintain homeostasis in the kidneys. METHODS: Using human renal... -
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- Cytoprotective Effect of Taurine against Hydrogen Peroxide-Induced Oxidative Stress in UMR-106 Cells through the Wnt/β-Catenin Signaling Pathway
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Lou J, Han D, Yu H, Yu G, Jin M, Kim SJ
- KMID: 2427512
- Biomol Ther.
- 2018 Nov;26(6):584-590.
- doi: 10.4062/biomolther.2018.049
Osteoporosis development is closely associated with oxidative stress and reactive oxygen species (ROS). Taurine has potential antioxidant effects, but its role in osteoblasts is not clearly understood. The aim of... -
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- Induction of heme oxygenase-1 with dietary quercetin reduces obesity-induced hepatic inflammation through macrophage phenotype switching
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Kim CS, Choi HS, Joe Y, Chung HT, Yu R
- KMID: 2359619
- Nutr Res Pract.
- 2016 Dec;10(6):623-628.
- doi: 10.4162/nrp.2016.10.6.623
BACKGROUND/OBJECTIVES: Obesity-induced steatohepatitis accompanied by activated hepatic macrophages/Kupffer cells facilitates the progression of hepatic fibrinogenesis and exacerbates metabolic derangements such as insulin resistance. Heme oxyganase-1 (HO-1) modulates tissue macrophage phenotypes... -
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- Ajoene, a Major Organosulfide Found in Crushed Garlic, Induces NAD(P)H:quinone Oxidoreductase Expression Through Nuclear Factor E2-related Factor-2 Activation in Human Breast Epithelial Cells
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Cho SJ, Ryu JH, Surh YJ
- KMID: 2454670
- J Cancer Prev.
- 2019 Jun;24(2):112-122.
- doi: 10.15430/JCP.2019.24.2.112
BACKGROUND: NAD(P)H:quinone oxidoreductase-1 (NQO1) is a widely-distributed flavin adenine dinucleotide-dependent flavoprotein that promotes obligatory 2-electron reductions of quinones, quinoneimines, nitroaromatics, and azo dyes. This reduces quinone levels and thereby minimizes... -
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- B6C3F1 mice exposed to ozone with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and/or dibutyl phthalate showed toxicities through alterations of NF-kappaB, AP-1, Nrf2, and osteopontin
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Kim MY, Song KS, Park GH, Chang SH, Kim HW, Park JH, Jin H, Eu KJ, Cho HS, Kang G, Kim YC, Cho MH
- KMID: 1120069
- J Vet Sci.
- 2004 Jun;5(2):131-137.
Toxic effects of ozone, 4-(N-methyl-N-nitrosamino)-1-(3- pyridyl)-1-butanone (NNK), and/or dibutyl phthalate (DBP) were examined through NF-kappaB, AP-1, Nrf2, and osteopontin (OPN) in lungs and livers of B6C3F1 mice. Electrophoretic mobility shift... -
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