- A Case of Lymphoplasmacytic Lymphoma/Waldenström's Macroglobulinemia with IgM-κ and IgA-λ Biclonal Gammopathy
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Shin WY, Bang HI, Kim J, Park R, Shin JW, Choi TY
- KMID: 2458690
- Lab Med Online.
- 2019 Oct;9(4):263-268.
- doi: 10.3343/lmo.2019.9.4.263
Lymphoplasmacytic lymphoma (LPL) is a low-grade B-cell neoplasm, composed of small B lymphocytes, plasmacytoid lymphocytes, and plasma cells, usually involving bone marrow and sometimes lymph nodes or spleen. LPL with... -
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- Pyrosequencing as a Fast and Reliable Method in Detecting the MYD88 p.L265P Mutation in Decalcified Formalin-Fixed and Paraffin-Embedded Tissues
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Gebauer N, Bernard V, Rohner C, Krokowski , Merz H, Feller AC, Thorns C
- KMID: 1791915
- Ann Lab Med.
- 2014 Mar;34(2):170-173.
- doi: 10.3343/alm.2014.34.2.170
No abstract available. -
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- Immunogenicity and efficacy of a plasmid DNA rabies vaccine incorporating Myd88 as a genetic adjuvant
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Ullas PT, Desai A, Madhusudana SN
- KMID: 1730625
- Clin Exp Vaccine Res.
- 2014 Jul;3(2):202-211.
- doi: 10.7774/cevr.2014.3.2.202
PURPOSE: Myeloid differentiation factor 88 (Myd88), a ubiquitous Toll-like receptor adaptor molecule, has been reported to play important roles in B cell responses to infections and vaccination. The present study... -
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- Carnosic acid inhibits TLR4-MyD88 signaling pathway in LPS-stimulated 3T3-L1 adipocytes
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Park MY, Mun ST
- KMID: 2313772
- Nutr Res Pract.
- 2014 Oct;8(5):516-520.
- doi: 10.4162/nrp.2014.8.5.516
BACKGROUND/OBJECTIVES: Carnosic acid (CA), found in rosemary (Rosemarinus officinalis) leaves, is known to exhibit anti-obesity and anti-inflammatory activities. However, whether its anti-inflammatory potency can contribute to the amelioration of obesity... -
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- Skewed Dendritic Cell Differentiation of MyD88-Deficient Donor Bone Marrow Cells, Instead of Massive Expansion as Myeloid-Derived Suppressor Cells, Aggravates GVHD
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Lee YK, Ju JM, Shon WJ, Oh S, Min CK, Kang MS, Shin DM, Choi EY
- KMID: 2429836
- Immune Netw.
- 2018 Dec;18(6):e44.
- doi: 10.4110/in.2018.18.e44
Graft-versus-host disease (GVHD), a life-threatening complication after bone marrow transplantation (BMT), is induced by activation of alloreactive donor T cells. Our previous study demonstrated that transplantation of myeloid differentiation factor... -
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- Cloning, expression and functional analysis of the duck Toll-like receptor 5 (TLR5) gene
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Cheng Y, Sun Y, Wang H, Shi S, Yan Y, Li J, Ding C, Sun J
- KMID: 2160819
- J Vet Sci.
- 2015 Mar;16(1):37-46.
- doi: 10.4142/jvs.2015.16.1.37
Toll-like receptor 5 (TLR5) is responsible for the recognition of bacterial flagellin in vertebrates. In the present study, the first TLR5 gene in duck was cloned. The open reading frame... -
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- MyD88 expression and anti-apoptotic signals of paclitaxel in epithelial ovarian cancer cells
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Suh DS, Jo MS, Yu SA, Kim KH, Yoon MS
- KMID: 2273860
- Korean J Obstet Gynecol.
- 2010 Apr;53(4):330-338.
- doi: 10.5468/kjog.2010.53.4.330
OBJECTIVE: The objectives of this study was to evaluate the correlation between myeloid differentiation protein 88 (MyD88) expression and paclitaxel effects on epithelial ovarian cancer cells and to evaluate whether... -
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- MyD88-BLT2-dependent cascade contributes to LPS-induced interleukin-6 production in mouse macrophage
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Lee AJ, Cho KJ, Kim JH
- KMID: 2070275
- Exp Mol Med.
- 2015 Apr;47(4):e156.
- doi: 10.1038/emm.2015.8
Endotoxic responses to bacterial lipopolysaccharide (LPS) are triggered by Toll-like receptor 4 (TLR4) and involve the production of inflammatory mediators, including interleukin-6 (IL-6), by macrophages. The detailed mechanism of IL-6... -
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- Grape seed proanthocyanidin extract ameliorates murine autoimmune arthritis through regulation of TLR4/MyD88/NF-κB signaling pathway
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Kim SH, Bang J, Son CN, Baek WK, Kim JM
- KMID: 2411590
- Korean J Intern Med.
- 2018 May;33(3):612-621.
- doi: 10.3904/kjim.2016.053
BACKGROUND/AIMS: Grape seed proanthocyanidin extract (GSPE) has been reported to have a beneficial effect on regulating inf lammation. However, the anti-inflammatory mechanism of GSPE remains unclear. The aim of this... -
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- Myeloid differentiation primary response protein 88 blockade upregulates indoleamine 2,3-dioxygenase expression in rheumatoid synovial fibroblasts
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Park MK, Oh HJ, Heo YM, Park EM, Cho ML, Kim HY, Park SH
- KMID: 1022119
- Exp Mol Med.
- 2011 Aug;43(8):446-454.
- doi: 10.3858/emm.2011.43.8.050
Indoleamine 2,3-dioxygenase (IDO) is a key negative regulator of immune responses and has been implicated in tumor tolerance, autoimmune disease and asthma. IDO was detected in the joint synovial tissue... -
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- Piperidylmethyloxychalcone improves immune-mediated acute liver failure via inhibiting TAK1 activity
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Park SH, Kwak JA, Jung SH, Ahn B, Cho WJ, Yun CY, Na CS, Hwang BY, Hong JT, Han SB, Kim Y
- KMID: 2396797
- Exp Mol Med.
- 2017 Nov;49(11):e392.
- doi: 10.1038/emm.2017.156
Mice deficient in the toll-like receptor (TLR) or the myeloid differentiation factor 88 (MyD88) are resistant to acute liver failure (ALF) with sudden death of hepatocytes. Chalcone derivatives from medicinal... -
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- Diallyl Trisulfide Suppresses the Production of Lipopolysaccharide-induced Inflammatory Mediators in BV2 Microglia by Decreasing the NF-κB Pathway Activity Associated With Toll-like Receptor 4 and CXCL12/CXCR4 Pathway Blockade
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Lee HH, Jeong JW, Hong SH, Park C, Kim BW, Choi YH
- KMID: 2425316
- J Cancer Prev.
- 2018 Sep;23(3):134-140.
- doi: 10.15430/JCP.2018.23.3.134
BACKGROUND: Diallyl trisulfide (DATS), a garlic-derived organosulfuric compound, has been documented for potential anti-inflammatory effects. However, the mechanism in microglia remains unknown. In this study, we investigated the anti-inflammatory effects... -
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- Porcine circovirus type 2 increases interleukin-1beta and interleukin-10 production via the MyD88–NF-kappa B signaling pathway in porcine alveolar macrophages in vitro
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Han J, Zhang S, Zhang Y, Chen M, Lv Y
- KMID: 2412571
- J Vet Sci.
- 2017 Jun;18(2):183-191.
- doi: 10.4142/jvs.2017.18.2.183
Porcine alveolar macrophages (PAMs) represent the first line of defense in the porcine lung after infection with porcine circovirus type 2 (PCV2) via the respiratory tract. However, PCV2 infection impairs... -
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- Prominent IL-12 Production and Tumor Reduction in Athymic Nude Mice after Toxoplasma gondii Lysate Antigen Treatment
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Pyo KH, Jung BK, Xin CF, Lee YW, Chai JY, Shin EH
- KMID: 2069810
- Korean J Parasitol.
- 2014 Dec;52(6):605-612.
- doi: 10.3347/kjp.2014.52.6.605
Toxoplasma gondii is an intracellular protozoan parasite that causes a Th1 cellular immunity. Our previous study showed that T. gondii lysate antigen (TLA) treatment in S180 tumor-bearing mice resulted in... -
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- Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8+ T cells
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Park SN, Noh KT, Jeong YI, Jung ID, Kang HK, Cha GS, Lee SJ, Seo JK, Kang DH, Hwang TH, Lee EK, Kwon B, Park YM
- KMID: 2154227
- Exp Mol Med.
- 2013 Feb;45(2):e8.
We evaluated the effectiveness of rhamnogalacturonan II (RG-II)-stimulated bone marrow-derived dendritic cells (BMDCs) vaccination on the induction of antitumor immunity in a mouse lymphoma model using EG7-lymphoma cells expressing ovalbumin... -
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