- Multidrug resistance-associated protein (MRP) and multidrug resistance (MDR1) gene expression in osteosarcoma and their prognostic significance
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Jung HG, Lee SH, Kim HS
- KMID: 2105711
- J Korean Orthop Assoc.
- 2001 Feb;36(1):1-8.
PURPOSE: The purpose of this study is to evaluate the correlations between the multidrug resistance-associated protein (MRP) and multidrug resistance (MDR1) gene in osteosarcoma, and their prognostic significances by RT-PCR... -
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- Expressions of Multidrug Resistance-Related Genes in Gastric Cancer Tissue and Normal Gastric Mucosal Tissue
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Song SH, Kim SW, Song SK, Choi JH, Ha JH, Lee KH
- KMID: 2270849
- Cancer Res Treat.
- 2001 Aug;33(4):302-308.
PURPOSE: This study was conducted to evaluate the expressions of the mdr1 gene and the MRP gene in tumor and adjacent normal gastric tissues. MATERIALS AND METHODS: The specimens were obtained... -
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- As2O3 Sensitivity in Acute Promyelocytic Leukemia and Refractory Acute Leukemia
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Lee S, Kim M, Lim J, Kim Y, Han K, Lee KY, Kang CS
- KMID: 1730177
- Korean J Lab Med.
- 2004 Apr;24(2):73-79.
BACKGROUND: Inorganic arsenic trioxide (As2O3) has emerged as a new drug of choice for refractory acute promyelocytic leukemia (APL). But, the curable disease spectrum and the arsenic resistance in association... -
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- Expression of Multidrug Resistance Genes, mdr1, mrp, Topo IIalpha and Topo IIbeta in Childhood Acute Lymphoblastic Leukemia
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Lim SH, Ko DH, Kook H, Yoon WS, Kim HJ, Kim SY, Kim CJ, Hwang TJ
- KMID: 2140617
- Korean J Pediatr Hematol Oncol.
- 2002 Apr;9(1):82-90.
PURPOSE: Multidrug resistance in the treatment of cancer mediated by several drug resistant genes impedes the successful management of cancer. The authors investigated the expression of drug resistant genes,... -
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- The Expression of Multidrug Resistance-Associated Protein (MRP) and the Chemosensitivity in Gastric Cancer Cell Lines
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Chang YK, Choi CH, Cha YJ, Rha HS, Jeong JH, Jang JH, Min YD
- KMID: 2209281
- J Korean Surg Soc.
- 2000 Jun;58(6):752-759.
PURPOSE: Gastric cancer cells may show resistance to various chemotherapeutic agents. The ability of cancer cells to become drug resistant is thought to be a cause of chemotherapy failure. Recent... -
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- Molecular aspects of organic ion transporters in the kidney
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Cha SH, Hitoshi E
- KMID: 2285231
- Korean J Physiol Pharmacol.
- 2001 Apr;5(2):107-122.
A function of the kidney is elimination of a variety of xenobiotics ingested and wasted endogenous compounds from the body. Organic anion and cation transport systems play important roles to protect the... -
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- Prognostic Significance of Expression of Glutathione S-Transferase-pi and Multidrug Resistance-Associated Protein in Nasopharyngeal Carcinoma
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Lim SC, Cho JS, Kim SH, Kim PS, Kim CG, Yoon JH
- KMID: 2275951
- Korean J Otolaryngol-Head Neck Surg.
- 2002 Aug;45(8):791-795.
BACKGROUND AND OBJECTIVES: For the treatment of nasopharyngeal carcinoma (NPC), radiation therapy is a primary option. Because of distant metastasis and the high incidence of a locoregional failure following radiotherapy,... -
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- Prognostic Significance of Multidrug Resistance Gene 1 (MDR1), Multidrug Resistance-related Protein (MRP) and Lung Resistance Protein (LRP) mRNA Expression in Acute Leukemia
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Huh HJ, Park CJ, Jang S, Seo EJ, Chi HS, Lee JH, Lee KH, Seo JJ, Moon HN, Ghim T
- KMID: 1781831
- J Korean Med Sci.
- 2006 Apr;21(2):253-258.
- doi: 10.3346/jkms.2006.21.2.253
The prognostic significance of multidrug resistance (MDR) gene expression is controversial. We investigated whether multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression... -
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- Expression of Multidrug Resistance (MDR1) and Multidrug Resistance Associated Protein (MRP) Genes in Pediatric Malignant Solid Tumors
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Seo YK, Jung HL, Kim DH, Yoo KH, Shim JY, Sung KW, Koo HH, Shin HY, Ahn HS, Wang KC, Cho BK
- KMID: 2140618
- Korean J Pediatr Hematol Oncol.
- 2002 Apr;9(1):91-100.
PURPOSE: Multidrug resistance (MDR) is one of the main obstacles in the successful anticancer chemotherapy. Classic MDR phenotype is characterized by overexpression of membrane bound permeability-glycoprotein (Pgp) drug-efflux pump,... -
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- Prognostic Significance of the Expression of MRP and p53 in Colorectal Carcinoma
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Chang JY, Min YD, Kim KC, Lim SC
- KMID: 2334086
- J Korean Soc Coloproctol.
- 1998 Sep;14(3):365-374.
Although MDR was previously thought to be predominantly caused by the expression of the MDR1 gene, it is now increasingly believed to be caused by other mechanism. Recently, over-expression of... -
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- The Relationship between Clinical Drug Sensitivity and Expression of Drug Resistance Genes in Patients with Acute Myelogenous Leukemia
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Kim KW, Kim HJ, Park SY
- KMID: 1832115
- Korean J Hematol.
- 2001 May;36(2):115-122.
BACKGROUND: The occurrence of drug resistance (DR) is one of the obstacles in the successful chemotherapeutic treatment of cancer. Multidrug resistance-1 (MDR-1), multidrug resistance associated protein (MRP), topoisomerase IIalpha (Topo... -
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- Plasmodium vivax Drug Resistance Genes; Pvmdr1 and Pvcrt-o Polymorphisms in Relation to Chloroquine Sensitivity from a Malaria Endemic Area of Thailand
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Rungsihirunrat K, Muhamad P, Chaijaroenkul W, Kuesap J, Na-Bangchang K
- KMID: 2381795
- Korean J Parasitol.
- 2015 Feb;53(1):43-49.
- doi: 10.3347/kjp.2015.53.1.43
The aim of the study was to explore the possible molecular markers of chloroquine resistance in Plasmodium vivax isolates in Thailand. A total of 30 P. vivax isolates were collected... -
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- TNFα Induces Multidrug Resistance-Associated Protein 4 Expression through p38-E2F1-Nrf2 Signaling in Obstructive Cholestasis
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Lian W, Liu X, Chen W
- KMID: 2460221
- Yonsei Med J.
- 2019 Nov;60(11):1045-1053.
- doi: 10.3349/ymj.2019.60.11.1045
PURPOSE: To explore the molecular mechanism of the upregulation of multidrug resistance-associated protein 4 (MRP4) in cholestasis. MATERIALS AND METHODS: The mRNA and protein levels of MRP4 in liver samples from... -
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- Expression analysis of genes related to multidrug resistance (MDR) in ovarian cancer cell line A2780 and cisplatinum resistant cell line A2780cp
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Lee JK, Na YJ, Lee YM, Chang SY, Moon YJ, Cho SH, Kim KT, Hwang YY
- KMID: 2076342
- Korean J Obstet Gynecol.
- 2001 Sep;44(9):1633-1638.
OBJECTIVE: Expressions of P-glycoprotein, the multidrug resistance-associated protein (MRP) and the lung resistance protein (LRP) with the MDR phenotype widely divergent in human cancer cell lines. This study focused on... -
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- Comparative Uptake of Tc-99m Sestamibi and Tc-99m Tetrofosmin in Cancer Cells and Tissue Expressing P-Glycoprotein or Multidrug Resistance Associated Protein
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Cho JA, Lee J, Yoo JA, Seo JH, Bae JH, Jeong SY, Ahn BC, Sohn SG, Ha JH, Lee K
- KMID: 1596252
- Korean J Nucl Med.
- 2005 Feb;39(1):34-43.
PURPOSE: 99mTc-sestamibi (MIBI) and 99mTc-tetrofosmin have been used as substrates for P-glycoprotein (Pgp) and multidrug resistance associated protein (MRP), which are closely associated with multidrug resistance of the tumors. To... -
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- 2,3,7,8-Tetrachlorodibenzo-P-Dioxin Induced Cell-Specific Drug Transporters With Acquired Cisplatin Resistance in Cisplatin Sensitive Cancer Cells
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Gotovdorj , Lee E, Lim Y, Cha EJ, Kwon D, Hong E, Kim Y, Oh MY
- KMID: 1794595
- J Korean Med Sci.
- 2014 Sep;29(9):1188-1198.
- doi: 10.3346/jkms.2014.29.9.1188
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can induce drug transporter genes such as the ATP-binding cassette G member 2 (ABCG2), which contributes to multidrug resistance. We investigated the effect of TCDD pretreatment on drug... -
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- Alteration of MRP2 expression and the graft outcome after liver transplantation
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Yi NJ, Kim J, Choi Y, Kim H, Lee KB, Jang JJ, Lee JY, Lee JM, Han JK, Lee KW, Suh KS
- KMID: 2422934
- Ann Surg Treat Res.
- 2018 Nov;95(5):249-257.
- doi: 10.4174/astr.2018.95.5.249
PURPOSE: Multidrug resistance-associated protein (MRP) 2 is a glutathione conjugate in the canalicular membrane of hepatocytes. Early graft damage after liver transplantation (LT) can result in alteration of MRP2 expression.... -
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- Expression of Multidrug Resistant Genes in Bone Marrow Mononuclear Cells of Patients with Myeloid Leukemia
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Cho SG, Yang IH, Eom HS, Min CG, Kim HJ, Kim DW, Lee JW, Han CW, Min WS, Kim WI, Kim CC
- KMID: 2175286
- J Korean Cancer Assoc.
- 1999 Feb;31(1):153-164.
PURPOSE: Multidrug resistance mediated by several drug resistant genes impedes the successful outcome of anti-cancer chemotherapy. In this study, we investigated the expressions of drug resistant genes encoding multidrug resistance... -
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- Treatment Outcome of Multidrug Resistance Related mRNA Expression and c-Jun-N-Terminal Kinase Activity in Patients with Acute Myeloid Leukemia
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Do JH, Oh SH, Song EJ, Chung JS, Kang CD, Lee EY
- KMID: 1781489
- Korean J Lab Med.
- 2007 Aug;27(4):229-236.
- doi: 10.3343/kjlm.2007.27.4.229
BACKGROUND: The multidrug resistance (mdr1), multidrug resistance associated protein (mrp1), and glutathione-s-transferase (gst) pi genes have been associated with treatment failure in acute myeloid leukemia (AML). c-jun N-terminal kinase... -
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- Introduction of Organic Anion Transporters (SLC22A) and a Regulatory Mechanism by Caveolins
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Lee WK, Jung SM, Kwak JO, Cha SH
- KMID: 2052264
- Electrolyte Blood Press.
- 2006 Mar;4(1):8-17.
- doi: 10.5049/EBP.2006.4.1.8
The kidney is an important organ for controlling the volume of body fluids, electrolytic balance and excretion/reabsorption of endogenous and exogenous compounds. Among these renal functions, excretion/reabsorption of endogenous and... -
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