- An inhibitory effect of tumor necrosis factor-alpha antagonist to gene expression in monocrotaline-induced pulmonary hypertensive rats model
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Kwon JH, Kim KC, Cho MS, Kim HS, Sohn S, Hong YM
- KMID: 2284282
- Korean J Pediatr.
- 2013 Mar;56(3):116-124.
- doi: 10.3345/kjp.2013.56.3.116
PURPOSE: Tumor necrosis factor (TNF)-alpha is thought to contribute to pulmonary hypertension. We aimed to investigate the effect of infliximab (TNF-alpha antagonist) treatment on pathologic findings and gene expression in... -
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- Effects of Bosentan Treatment on Angiotensin Converting Enzyme in Monocrotaline Induced Pulmonary Hypertension Rats
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Kim SJ, Cha JH, Lee HR, Hong YM
- KMID: 2099899
- J Korean Soc Hypertens.
- 2011 Mar;17(1):28-36.
- doi: 10.5646/jksh.2011.17.1.28
BACKGROUND: Pulmonary artery hypertension is characterized by persistent increase of vascular resistance, and is associated with right ventricle failure. We investigated changes of plasma renin, serum aldosterone, angiotensin converting enzyme... -
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- Expression of TGF-beta and PDGF in Monocrotaline-Induced Pulmonary Hypertension in Rats
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Cho MS, Cho SH, Yang WI, Han WS
- KMID: 2073686
- Korean J Pathol.
- 1999 Aug;33(8):545-554.
Pulmonary vascular hypertension is characterized by migration and proliferation of smooth muscle cells accompanying abnormal synthesis and accumulation of extracellular proteins in vascular wall. The aim of this study is... -
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- Increased expression of nitric oxide synthases in left and right ventricular hypertrophy
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Lee JU, Oh YW, Kim S, Kang DG, Lee WJ
- KMID: 1606840
- Korean J Physiol Pharmacol.
- 2001 Feb;5(1):65-70.
The present study was aimed to explore pathophysiological implications of nitric oxide in the development of left and right ventricular hypertrophy. To induce selective left and right ventricular hypertrophy, rats were made two-kidney,... -
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- Assessment of Right Ventricular Function by Tissue Doppler Imaging in Pulmonary Arterial Hypertensive Rat
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Hong JE, Kim KC, Hong YM
- KMID: 2454664
- Ewha Med J.
- 2019 Jul;42(3):39-45.
- doi: 10.12771/emj.2019.42.3.39
OBJECTIVES: Elevated pulmonary pressure and right ventricular (RV) dysfunction are the hallmarks of pulmonary vascular disease in animal models and human patients with pulmonary arterial hypertension (PAH). Monocrotaline models of... -
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- Enhanced Expression of Aldosterone Synthase and Adrenomedullin in Left and Right Ventricular Hypertrophy in Rats
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Lee JU, Lee S, Kim S, Lee WJ
- KMID: 1615003
- Korean J Physiol Pharmacol.
- 2002 Apr;6(2):121-126.
The pathophysiological implications of aldosterone and adrenomedullin in the cardiac ventricular hypertrophy were examined. Male Sprague-Dawley rats were treated with deoxycorticosterone acetate (DOCA)-salt and monocrotaline (MCT) to selectively elicit left... -
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- Changes of Gene Expression after Bone Marrow Cell Transfusion in Rats with Monocrotaline-Induced Pulmonary Hypertension
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Kim KC, Lee HR, Kim SJ, Cho MS, Hong YM
- KMID: 1421611
- J Korean Med Sci.
- 2012 Jun;27(6):605-613.
- doi: 10.3346/jkms.2012.27.6.605
Pulmonary artery hypertension (PAH) causes right ventricular failure and possibly even death by a progressive increase in pulmonary vascular resistance. Bone marrow-derived mesenchymal stem cell therapy has provided an alternative... -
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- Effect of Ambrisentan Therapy on the Expression of Endothelin Receptor, Endothelial Nitric Oxide Synthase and NADPH Oxidase 4 in Monocrotaline-induced Pulmonary Arterial Hypertension Rat Model
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Lee H, Yeom A, Kim KC, Hong YM
- KMID: 2455794
- Korean Circ J.
- 2019 Sep;49(9):866-876.
- doi: 10.4070/kcj.2019.0006
BACKGROUND AND OBJECTIVES: Elevated endothelin (ET)-1 level is strongly correlated with the pathogenesis of pulmonary arterial hypertension (PAH). Expression level of nicotinamide adenine dinucleotide phosphate oxidase (NOX) 4 is increased... -
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- Gene Expression of Endothelin-1 and Endothelin Receptor A on Monocrotaline-Induced Pulmonary Hypertension in Rats After Bosentan Treatment
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Lim KA, Kim KC, Cho MS, Lee BE, Kim HS, Hong YM
- KMID: 1456139
- Korean Circ J.
- 2010 Sep;40(9):459-464.
- doi: 10.4070/kcj.2010.40.9.459
BACKGROUND AND OBJECTIVES: Endothelin (ET)-1, a potent endothelium-derived vasoconstrictor peptide, has a potential pathophysiologic role in pulmonary hypertension. Bosentan, a dual ET receptor (ET(A)/ET(B)) antagonist, is efficacious in treatment of... -
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- Gene Expressions of Nitric Oxide Synthase and Matrix Metalloproteinase-2 in Monocrotaline-Induced Pulmonary Hypertension in Rats After Bosentan Treatment
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Koo HS, Kim KC, Hong YM
- KMID: 2225140
- Korean Circ J.
- 2011 Feb;41(2):83-90.
- doi: 10.4070/kcj.2011.41.2.83
BACKGROUND AND OBJECTIVES: Nitric oxide (NO) is a major endothelium dependent vasomediator and growth inhibitor. NO synthesis is catalyzed by endothelial nitric oxide synthase (eNOS), and NO can also produce... -
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- Hypoxic pulmonary vasoconstriction and vascular contractility in monocrotaline-induced pulmonary arterial hypertensive rats
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Kim HJ, Yoo HY
- KMID: 2364268
- Korean J Physiol Pharmacol.
- 2016 Nov;20(6):641-647.
- doi: 10.4196/kjpp.2016.20.6.641
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by vascular remodeling of pulmonary arteries (PAs) and increased vascular resistance in the lung. Monocrotaline (MCT), a toxic alkaloid, is widely... -
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- Effect of endothelin receptor blockade on monocrotaline-induced pulmonary hypertension in rats
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Lim KA, Shim JY, Cho SH, Kim KC, Han JJ, Hong YM
- KMID: 2281074
- Korean J Pediatr.
- 2009 Jun;52(6):689-695.
- doi: 10.3345/kjp.2009.52.6.689
PURPOSE: To examine the effect of bosentan, a dual endothelin receptor (ER) antagonist, on the development of monocrotaline (MCT)-induced pulmonary hypertension in rats by especially focusing on the pulmonary vascular... -
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- Apoptosis and Inflammation Associated Gene Expressions in Monocrotaline-Induced Pulmonary Hypertensive Rats after Bosentan Treatment
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Hong YM, Kwon JH, Choi S, Kim KC
- KMID: 2223898
- Korean Circ J.
- 2014 Mar;44(2):97-104.
- doi: 10.4070/kcj.2014.44.2.97
BACKGROUND AND OBJECTIVES: Vascular wall remodeling in pulmonary hypertension can be caused by an aberration in the normal balance between proliferation and apoptosis of endothelial cell in the pulmonary artery.... -
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- Changes of Pulmonary Pathology and Gene Expressions After Simvastatin Treatment in the Monocrotaline-Induced Pulmonary Hypertension Rat Model
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Lee YH, Kim KC, Cho MS, Hong YM
- KMID: 2094104
- Korean Circ J.
- 2011 Sep;41(9):518-527.
- doi: 10.4070/kcj.2011.41.9.518
BACKGROUND AND OBJECTIVES: Simvastatin's properties are suggestive of a potential pathophysiologic role in pulmonary hypertension. The objectives of this study were to investigate changes of pulmonary pathology and gene expressions,... -
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- The effect of sildenafil on right ventricular remodeling in a rat model of monocrotaline-induced right ventricular failure
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Bae HK, Lee H, Kim KC, Hong YM
- KMID: 2353156
- Korean J Pediatr.
- 2016 Jun;59(6):262-270.
- doi: 10.3345/kjp.2016.59.6.262
PURPOSE: Pulmonary arterial hypertension (PAH) leads to right ventricular failure (RVF) as well as an increase in pulmonary vascular resistance. Our purpose was to study the effect of sildenafil on... -
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- Simvastatin, Sildenafil and Their Combination in Monocrotaline Induced Pulmonary Arterial Hypertension
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Lee DS, Kim YK, Jung YW
- KMID: 2225165
- Korean Circ J.
- 2010 Dec;40(12):659-664.
- doi: 10.4070/kcj.2010.40.12.659
BACKGROUND AND OBJECTIVES: Pulmonary arterial hypertension (PAH) is a life threatening disease characterized by progressive pulmonary arterial occlusion which may ultimately result in death. Currently, the available treatments are diverse,... -
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- Resveratrol Attenuates Monocrotaline-Induced Pulmonary Hypertension in Rats
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Lee DS, Jung JY, Jung YW
- KMID: 2029030
- Korean Circ J.
- 2006 Oct;36(10):683-687.
- doi: 10.4070/kcj.2006.36.10.683
BACKGROUND AND OBJECTIVES : Resveratrol (RVT) is a polyphenolic phytoalexin, and it has been demonstrated to be capable of protecting against cardiovascular disease. The aim of this study was to... -
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- Microarray analysis after umbilical cord blood derived mesenchymal stem cells injection in monocrotaline-induced pulmonary artery hypertension rats
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Lee JC, Kim KC, Yang YS, Oh W, Choi SJ, Choe SY, Hong YM
- KMID: 1882600
- Anat Cell Biol.
- 2014 Dec;47(4):217-226.
- doi: 10.5115/acb.2014.47.4.217
Pulmonary arterial hypertension (PAH) is associated with structural alterations of lung vasculature. PAH is still a devastating disease needing an aggressive therapeutic approach. Despite the therapeutic potential of human umbilical... -
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- Microarray Analysis in Pulmonary Hypertensive Rat Heart after Simvastatin Treatment
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Kim YK, Kim KC, Hong YM
- KMID: 2417942
- Ewha Med J.
- 2018 Jul;41(3):53-62.
- doi: 10.12771/emj.2018.41.3.53
OBJECTIVES: Simvastatin has been reported to attenuate the development of pulmonary hypertension through increased apoptosis as well as reduced proliferation of smooth muscle cells in obstructive vascular lesions. Microarray experiment... -
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- Effect of Small Hairpin RNA Targeting Endothelin-Converting Enzyme-1 in Monocrotaline-Induced Pulmonary Hypertensive Rats
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Son JS, Kim KC, Kim BK, Cho MS, Hong YM
- KMID: 2157974
- J Korean Med Sci.
- 2012 Dec;27(12):1507-1516.
- doi: 10.3346/jkms.2012.27.12.1507
The purpose of this study was to investigate the therapeutic effects of small hairpin RNA (shRNA) targeting endothelin-converting enzyme (ECE)-1 in monocrotaline (MCT)-induced pulmonary hypertensive rats. Ninty-four Sprague-Dawley rats were... -
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