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Thymic epithelial cells of severe combined immunodeficiency (SCID) mice

Lee I, Yu E, Ikehara S

To characterize thymic epithelial cells of SCID (severe combined immunodeficiency) mice in comparison with those of Balb C mice, we did an immunohistochemical study using cortical and medullary epithelial cell...
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Antitumor Effect of Methotrexate in SCID Mice with Human Leukemia CCRF-CEM Cell Line

Choi YK, Choi JY, Hyun BH, Kim YJ, Lee CH, Yoon WK, Jeong KS, Kim DY

  • KMID: 1531904
  • J Korean Cancer Assoc.
  • 1997 Feb;29(1):19-28.
No abstract available
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Growth and Metastasis of MCF-7 Breast Cancer Cells Grafted to huPBMC-SCID Mouse

Park SH, Choi DL, Park KH, Joo DH, Lee HI, Yoo YO, Park KH, Suh IS

PURPOSE: The severe combined immunodeficient (SCID) mice which lack the functional T and B lymphocytes have been widely used for the research of various human diseases including AIDS, transplantation, autoimmune...
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Rodent model for long-term maintenance and development of the viable cysticerci of Taenia saginata asiatica

Wang IC, Chung WC, Lu SC, Fan PC

Although oncospheres of Taenia saginata asiatica can develop into cysticerci in immunodeficiency, immunosuppressed, and normal mice, no detailed information on the development features of these cysticerci from SCID mice...
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Identification of newly isolated Babesia parasites from cattle in Korea by using the Bo-RBC-SCID mice

Cho SH, Kim TS, Lee HW, Tsuji M, Ishihara C, Kim JT, Wee SH, Lee CG

Attempts were made to isolate and identify Korean bovine Babesia parasite. Blood samples were collected from Holstein cows in Korea, and Babesia parasites were propagated in SCID mice with circulating...
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Expression of Cell Surface Receptors on Human Glioblastoma Xenograft Model in NOD/SCID Mouse

Oh KS, Kim KU, Park NH, Seo SY, Choi SS, Huh GY

  • KMID: 1972969
  • Cancer Res Treat.
  • 2002 Feb;34(1):52-57.
PURPOSE: To obtain basic data for development of a glioblastoma-specific immunotoxin, the expression of variable cell surface receptors on a human glioblastoma xenograft model was evaluated, using NOD/SCID mice. MATERIALS AND...
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Adoptive transfer of Porphyromonas gingivalis heat shock protein epitope-specific T-cell lines into SCID mice in experimental atherosclerosis

Choi J, Witztum J

Bacterial heat shock protein has been one of the components that are responsible to induce autoimmune disease mechanisms in the pathogenesis of atherosclerosis due to high level of homology in...
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Cotransplanted Bone Marrow Derived Mesenchymal Stem Cells (MSC) Enhanced Engraftment of Hematopoietic Stem Cells in a MSC-dose Dependent Manner in NOD/SCID Mice

Kim DH, Yoo KH, Yim YS, Choi J, Lee SH, Jung HL, Sung KW, Yang SE, Oh WI, Yang YS, Kim SH, Choi SY, Koo HH

Transplantation of marrow-derived mesenchymal stem cells (MSCs), expanded by culture in addition to whole bone marrow, has been shown to enhance engraftment of human hematopoietic stem cells (HSCs). Our hypothesis...
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Antitumor Activity of TRAIL Recombinant Adenovirus in Human Malignant Glioma Cells

Kim KU, Seo SY, Heo KY, Yoo YH, Kim HJ, Lee HS, Choi SS, Hwang TH, Lee HJ

Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL) has been reported to specifically kill malignant cells but to be relatively nontoxic to normal cells. One of disadvantages to previous in vivo protocols...
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Co-transplantation of Human Mesenchymal Stem Cells Promotes Human CD34+ Cells Engraftment in a Dose-dependent Fashion in NOD/SCID Mice

Park SK, Won JH, Kim HJ, Bae SB, Kim CK, Lee KT, Lee NS, Lee YK, Jeong DC, Chung NG, Kim HS, Hong DS, Park HS

Mesenchymal stem cells (MSCs) have recently been identified and characterized in humans. Moreover, MSC secrete cytokines that can support hematopoietic progenitor growth. In the present study, we evaluated whether the...
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Effect of Immune System on Retrovirus-Mediated Herpes Simplex Virus Thymidine Kinase Gene Therapy

Park JY, Joo S, Chang HJ, Son JW, Kim KY, Kim KS, Kim CH, Park JH, Lee JK, Jung TH

BACKGROUND: The impact of the immune response on cancer gene therapy using viral vectors to deliver a "suicide gene" is currently unclear. A vigrous immune response targeted at viral proteins...
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HR-1 Mice: A New Inflammatory Acne Mouse Model

Jang YH, Lee KC, Lee SJ, Kim DW, Lee WJ

BACKGROUND: There is no appropriate in vivo animal model that reflects the inflammatory response of human acne. OBJECTIVE: This study investigated the effect of Propionibacterium acnes on the development of inflammatory...
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Effect of Human Parathyroid Hormone on Hematopoietic Progenitor Cells in NOD/SCID Mice Co-Transplanted with Human Cord Blood Mononuclear Cells and Mesenchymal Stem Cells

Lim YJ, Hwang K, Kim M, Cho YH, Lee JH, Lee YH, Seo JJ

PURPOSE: We evaluated the effect of human parathyroid hormone (hPTH) on the engraftment and/or in vivo expansion of hematopoietic stem cells in an umbilical cord blood (UCB)-xenotransplantation model. In addition,...
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Effect of suramin on differentiation of human stomach cancer cell lines

Choe G, Kim WH, Park JG, Kim YI

This study was designed to demonstrate that differentiation of stomach cancer cells can be modified by microenvironmental change and to look for a method inducing or promoting tumor cell...
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Modeling EBV infection and pathogenesis in new-generation humanized mice

Fujiwara S, Imadome KI, Takei M

The development of highly immunodeficient mouse strains has allowed the reconstitution of functional human immune system components in mice. New-generation humanized mice generated in this manner have been extensively used...
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Establishment and Characterization of a Small Cell Lung Cancer Cell Line(JePa-1)

Lee MJ, Jeon HJ, Chung JH

  • KMID: 2275738
  • Korean J Pathol.
  • 1997 Aug;31(8):695-710.
Lung cancer is the most common malignant tumor worldwide and its incidence continues to rise each year. Recent development of molecular biologic method has led to advances in determining the...
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A Study for the Biologic Changes and Viability of Adipose Tissue in Cryopreserved Fat Graft

Han JJ, Kwon YS, Lee JH, Heo J, Lee KC, Kim MH, Kim SK

  • KMID: 2120358
  • J Korean Soc Plast Reconstr Surg.
  • 2009 Mar;36(2):127-134.
PURPOSE: Adipose tissue injection as a free graft for the correction of soft-tissue deficiency or depression deformity is a widespread procedure in plastic surgery. This study is to analyze the...
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Pleiotrophin effects on binding and subsequent osteogenesis of human mesenchymal stem cells

Yoon JH, Eune JJ, Jang HS, Rim JS, Lee ES, Kim DS, Kwon JJ

  • KMID: 1960528
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2006 Mar;28(2):111-117.
An area of current research is investigating the app1ication of human mesenchymal stem cells or hMSCs as a cell-based regenerative therapy. In order to achieve effective bone regeneration, appropriate matrices...
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Cotransplantation of Cord Blood Hematopoietic Stem Cells and Culture-Expanded and GM-CSF-/SCF-Transfected Mesenchymal Stem Cells in SCID Mice

Han JY, Goh RY, Seo SY, Hwang TH, Kwon HC, Kim SH, Kim JS, Kim HJ, Lee YH

Mesenchymal stem cells (MSC) are multipotent in nature and believed to facilitate the engraftment of hematopoietic stem cells (HSC) when transplanted simultaneously in animal studies and even in human trials....
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Production of the Recombinant Single Chain Anti-B Cell Lymphoma Antibody and Evaluation of Immunoreactivity

Jung JH, Choi TH, Woo KS, Chung WS, Kim SG, Cheon GJ, Choi CW, Lim SM

  • KMID: 1512532
  • Nucl Med Mol Imaging.
  • 2006 Aug;40(4):211-217.
PURPOSE: Recombinant ScFv lym-1 was produced, using pET vector system for large scale production. METHODS: ScFv lym-1 gene inserted pET-22b (+) vector, was expressed in E.coli BL-21 strain. ScFv lym-1 antibody...
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