- The SCAP/SREBP Pathway: A Mediator of Hepatic Steatosis
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Moon YA
- KMID: 2413279
- Endocrinol Metab.
- 2017 Mar;32(1):6-10.
- doi: 10.3803/EnM.2017.32.1.6
Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance, obesity, and dyslipidemia. NAFLD encompasses a wide range of states from the simple accumulation of triglycerides in the hepatocytes... -
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- Effects of Eupatilin on Insulin-Like Growth Factor 1-Induced Lipogenesis and Inflammation of SZ95 Sebocytes
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Lee JH, Lee YJ, Song JY, Kim YH, Lee JY, Zouboulis , Park YM
- KMID: 2451494
- Ann Dermatol.
- 2019 Aug;31(4):479-482.
- doi: 10.5021/ad.2019.31.4.479
No abstract available. -
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- Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis
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Koo SH
- KMID: 1705200
- Clin Mol Hepatol.
- 2013 Sep;19(3):210-215.
- doi: 10.3350/cmh.2013.19.3.210
Liver plays a central role in the biogenesis of major metabolites including glucose, fatty acids, and cholesterol. Increased incidence of obesity in the modern society promotes insulin resistance in the... -
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- Glycogen Synthase Kinase 3 Inactivation Induces Cell Senescence through Sterol Regulatory Element Binding Protein 1-Mediated Lipogenesis in Chang Cells
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Kim YM, Song I, Seo YH, Yoon G
- KMID: 2169308
- Endocrinol Metab.
- 2013 Dec;28(4):297-308.
- doi: 10.3803/EnM.2013.28.4.297
BACKGROUND: Enhanced lipogenesis plays a critical role in cell senescence via induction of expression of the mature form of sterol regulatory element binding protein 1 (SREBP1), which contributes to an... -
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- Targeting Lipid Metabolic Reprogramming as Anticancer Therapeutics
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Cha JY, Lee HJ
- KMID: 2367557
- J Cancer Prev.
- 2016 Dec;21(4):209-215.
- doi: 10.15430/JCP.2016.21.4.209
Cancer cells rewire their metabolism to satisfy the demands of growth and survival, and this metabolic reprogramming has been recognized as an emerging hallmark of cancer. Lipid metabolism is pivotal... -
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- Bilateral Vocal Cord Palsy Associated with Multiple Symmetrical Lipomatosis(Madelung's Disease)
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Jung H, Eom JW
- KMID: 2276741
- Korean J Otolaryngol-Head Neck Surg.
- 2007 Apr;50(4):358-361.
Multiple symmetrical lipomatosis (MSL) is a rare disorder characterized by the presence of multiple, symmetric, unencapsulated fat masses in the face, neck, and other areas. Typically, this entity has been... -
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- Leucrose, a Sucrose Isomer, Suppresses Hepatic Fat Accumulation by Regulating Hepatic Lipogenesis and Fat Oxidation in High-fat Diet-induced Obese Mice
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Lee J, Kim E, Kim Y, Yoo SH
- KMID: 2417374
- J Cancer Prev.
- 2018 Jun;23(2):99-106.
- doi: 10.15430/JCP.2018.23.2.99
Obesity is currently one of the most serious public health problems and it can lead to numerous metabolic diseases. Leucrose, d-glucopyranosyl-α-(1-5)-d-fructopyranose, is an isoform of sucrose and it is naturally... -
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- Insulin Resistance During Pregnancy
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Ahn KJ
- KMID: 2298063
- Korean Diabetes J.
- 2009 Apr;33(2):77-82.
- doi: 10.4093/kdj.2009.33.2.77
Pregnancy is a complex metabolic state involving dramatic alterations in the hormonal or cytokine environments (increases in estrogen, progesterone, prolactin, cortisol, human chorionic gonadotropin, placental growth hormone and human placental... -
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- Effects of Genistein Supplementation on Fatty Liver and Lipid Metabolism in Rats Fed High Fat Diet
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Lee SH, Kim MH, Park MN, Lee YS
- KMID: 2260668
- Korean J Nutr.
- 2007 Dec;40(8):693-700.
This study was performed to investigate the effects of genistein, a kind of soy isoflavones, on fatty liver and lipid metabolism in rats fed high fat diet. Twenty four male... -
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- GLP-1 Receptor Agonist and Non-Alcoholic Fatty Liver Disease
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Lee J, Hong SW, Rhee EJ, Lee WY
- KMID: 2174417
- Diabetes Metab J.
- 2012 Aug;36(4):262-267.
- doi: 10.4093/dmj.2012.36.4.262
Non-alcoholic fatty liver disease (NAFLD), one of the most common liver diseases, is caused by the disruption of hepatic lipid homeostasis. It is associated with insulin resistance as seen in... -
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- BAFF knockout improves systemic inflammation via regulating adipose tissue distribution in high-fat diet-induced obesity
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Kim DH, Do MS
- KMID: 2155394
- Exp Mol Med.
- 2015 Jan;47(1):e129.
- doi: 10.1038/emm.2014.98
Obesity is recognized as a chronic low-grade inflammatory state due to adipose tissue expansion being accompanied by an increase in the production of proinflammatory adipokines. Our group is the first... -
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- Definition, Pathogenesis, and Natural Progress of Non-alcoholic Fatty Liver Disease
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Jeon JH, Park KG
- KMID: 2173896
- J Korean Diabetes.
- 2014 Jun;15(2):65-70.
- doi: 10.4093/jkd.2014.15.2.65
Non-alcoholic fatty liver disease (NAFLD) is emerging as a world-wide health problem and is currently recognized as a hepatic manifestation of metabolic syndrome. It is an umbrella term to describe... -
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- Cilostazol inhibits insulin-stimulated expression of sterol regulatory binding protein-1c via inhibition of LXR and Sp1
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Jung YA, Kim HK, Bae KH, Seo HY, Kim HS, Jang BK, Jung GS, Lee IK, Kim MK, Park KG
- KMID: 2155338
- Exp Mol Med.
- 2014 Jan;46(1):e73.
- doi: 10.1038/emm.2013.143
Hepatic steatosis is common in obese individuals with hyperinsulinemia and is an important hepatic manifestation of metabolic syndrome. Sterol regulatory binding protein-1c (SREBP-1c) is a master regulator of lipogenic gene... -
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- Inhibition of Serotonin Synthesis Induces Negative Hepatic Lipid Balance
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Namkung J, Shong KE, Kim H, Oh CM, Park S, Kim H
- KMID: 2413986
- Diabetes Metab J.
- 2018 Jun;42(3):233-243.
- doi: 10.4093/dmj.2017.0084
BACKGROUND: Hepatic steatosis is caused by metabolic stress associated with a positive lipid balance, such as insulin resistance and obesity. Previously we have shown the anti-obesity effects of inhibiting serotonin... -
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- Inhibition of Insulin-Like Growth Factor-1–Induced Sebum Production by Bilobetin in Cultured Human Sebocytes
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Wang C, Hwang YL, Li XM, Kim SJ, Zhu MJ, Lee JH, Jiang RH, Kim CD
- KMID: 2444861
- Ann Dermatol.
- 2019 Jun;31(3):294-299.
- doi: 10.5021/ad.2019.31.3.294
BACKGROUND: Sebocytes are the major cells of sebaceous gland. The essential role of sebocytes is the production of sebum, a specific lipid mixture, that covers the body surface and provides... -
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- Effects of Alcohol on Obesity and Metabolic Syndrome
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Oh SW
- KMID: 2270810
- Korean J Obes.
- 2009 Mar;18(1):1-7.
Alcohol is one of the major public health problems in Korea. Korea has one of the highest heavy drinking rates among OECD nations (63.4%) and drinking rates have increased even... -
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- Dietary carnosic acid suppresses hepatic steatosis formation via regulation of hepatic fatty acid metabolism in high-fat diet-fed mice
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Park MY, Mun ST
- KMID: 2313683
- Nutr Res Pract.
- 2013 Aug;7(4):294-301.
In this study, we examined the hepatic anti-steatosis activity of carnosic acid (CA), a phenolic compound of rosemary (Rosmarinus officinalis) leaves, as well as its possible mechanism of action, in... -
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- Platycodin D May Improve Acne and Prevent Scarring by Downregulating SREBP-1 Expression Via Inhibition of IGF-1R/PI3K/Akt Pathway and Modulating Inflammation with an Increase in Collagen
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Suh Y, Yang JH, Yoon JY, Choi YS
- KMID: 2419749
- Ann Dermatol.
- 2018 Oct;30(5):581-587.
- doi: 10.5021/ad.2018.30.5.581
BACKGROUND: Although many therapeutic agents have been developed, only a few drugs are known to target multiple pathogenic factors in the treatment of acne. OBJECTIVE: The purpose of this study was... -
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- Rosiglitazone Activates AMPK and Improves Non-Alcoholic Fatty Liver Disease in OLETF Rats
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Cho EH, Lee KU
- KMID: 2222510
- Korean Diabetes J.
- 2008 Apr;32(2):141-148.
- doi: 10.4093/kdj.2008.32.2.141
BACKGROUND: Insulin resistance is very common in patients with nonalcoholic fatty liver disease (NAFLD). Glitazones improve insulin sensitivity by acting as a selective agonist of the peroxisome proliferators -activated receptor... -
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- Free fatty acid-induced histone acetyltransferase activity accelerates lipid accumulation in HepG2 cells
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Chung S, Hwang JT, Park JH, Choi HK
- KMID: 2453283
- Nutr Res Pract.
- 2019 Jun;13(3):196-204.
- doi: 10.4162/nrp.2019.13.3.196
BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disease triggered by epigenetic alterations, including lysine acetylation at histone or non-histone proteins, affecting the stability or transcription of lipogenic... -
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