- Leukotrienes and Allergic Inflammation
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- KMID: 1969527
- Korean J Asthma Allergy Clin Immunol.
- 2012 Jun;32(2):67-72.
Leukotrienes (LTs) are important lipid mediators involved in allergic inflammation. The LT pathway is relatively steroid-resistant, which suggests the possibility that its blockade by alternative means may facilitate asthma management.... -
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- Effects of Eupatilin on the Release of Leukotriene B4 , by Helicobacter pylori - stimulated Neutrophils and Gastric Mucosal Cells
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Lee JJ, Han BG, Kim MN, Chung MH
- KMID: 1943439
- J Korean Soc Microbiol.
- 1997 Dec;32(6):659-666.
Leukotrienes (LTs) are known to act as a mediator provoking tissue response in inflammation. LTs, particularly type B4 (LTB4) as chemotactic factor of neutrophil are released from neutrophils and gastric... -
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- Effect of Leukotriene B4 and Thromboxane B2 on Lumbar Nerve Roots in Rat
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Baek DH, Jahng J, Ha KY
- KMID: 2322845
- J Korean Soc Spine Surg.
- 2001 Mar;8(1):8-14.
STUDY DESIGN: The motor impairment and sensory dysfunction were evaluated in twenty-eight rats after dropping of leukotriene B4 and thromboxane B2 on lumbar nerve roots. OBJECTIVES: To evaluate the effects... -
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- A rare case of Sjogren-Larsson syndrome with recurrent pneumonia and asthma
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Tavasoli A, Sayyahfar , Behnam B
- KMID: 2353158
- Korean J Pediatr.
- 2016 Jun;59(6):276-279.
- doi: 10.3345/kjp.2016.59.6.276
Sjogren-Larsson syndrome (SLS) is a rare autosomal recessive neurocutaneous disorder with worldwide incidence of 0.4 per 100,000 people. It is characterized by the triad of congenital ichthyosis, spastic diplegia or... -
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- MyD88-BLT2-dependent cascade contributes to LPS-induced interleukin-6 production in mouse macrophage
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Lee AJ, Cho KJ, Kim JH
- KMID: 2070275
- Exp Mol Med.
- 2015 Apr;47(4):e156.
- doi: 10.1038/emm.2015.8
Endotoxic responses to bacterial lipopolysaccharide (LPS) are triggered by Toll-like receptor 4 (TLR4) and involve the production of inflammatory mediators, including interleukin-6 (IL-6), by macrophages. The detailed mechanism of IL-6... -
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- Leukotriene B4 pathway regulates the fate of the hematopoietic stem cells
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Chung JW, Kim GY, Mun YC, Ahn JY, Seong CM, Kim JH
- KMID: 1033100
- Exp Mol Med.
- 2005 Feb;37(1):45-50.
Leukotriene B4(LTB4), derived from arachidonic acid, is a potent chemotactic agent and activating factor for hematopoietic cells. In addition to host defense in vivo, several eicosanoids have been reported to... -
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- Effect of theophylline on urinary leukotriene B4 and C4 excretion in children with asthma
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Chung HL, Lee JJ, Kim SG
- KMID: 2054865
- J Asthma Allergy Clin Immunol.
- 2000 Oct;20(5):710-716.
BACKGROUND: Theophylline has been used in the treatment of asthma for decades as a broncho- dilator, but recent studies suggested that it has anti-inflammatory and immunomodulatory properties. OBJECTIVE: The aim... -
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- Study on the action by PAF on IL-1 modulation in alveolar macrophages: Involvement of endogenous arachidonate metabolites and intracellular Ca++ mobilization
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Lee J, Kim WK, Hah JS
- KMID: 1562327
- Korean J Physiol Pharmacol.
- 1998 Apr;2(2):241-249.
Platelet-activating factor (PAF) enhanced interleukin-1 (IL-1) activity by the interaction with a specific receptor in rat alveolar macrophages. In this study, we investigated the role of endogenous arachidonate metabolites and intracellular calcium mobilization... -
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- Diverse characters of Brennan’s paw incision model regarding certain parameters in the rat
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Kumar R, Gupta S, Gautam M, Jhajhria S, Ray SB
- KMID: 2455612
- Korean J Pain.
- 2019 Jul;32(3):168-177.
- doi: 10.3344/kjp.2019.32.3.168
BACKGROUND: Brennan’s rodent paw incision model has been extensively used for understanding mechanisms underlying postoperative pain in humans. However, alterations of physiological parameters like blood pressure and heart rate, or... -
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- Leukotriene B(4) receptor 2 gene polymorphism (rs1950504, Asp196Gly) leads to enhanced cell motility under low-dose ligand stimulation
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Jang JH, Wei JD, Kim M, Kim JY, Cho AE, Kim JH
- KMID: 2396807
- Exp Mol Med.
- 2017 Nov;49(11):e402.
- doi: 10.1038/emm.2017.192
Recently, single-nucleotide polymorphisms (SNPs) in G-protein-coupled receptors (GPCRs) have been suggested to contribute to physiopathology and therapeutic effects. Leukotriene B4 receptor 2 (BLT2), a member of the GPCR family, plays... -
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- Low-dose UVB irradiation stimulates matrix metalloproteinase-1 expression via a BLT2-linked pathway in HaCaT cells
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Kim C, Ryu HC, Kim JH
- KMID: 1115267
- Exp Mol Med.
- 2010 Dec;42(12):833-841.
- doi: 10.3858/emm.2010.42.12.086
Skin exposure to low-dose ultraviolet B (UVB) light up-regulates the expression of matrix metalloproteinase-1 (MMP-1), thus contributing to premature skin aging (photo-aging). Although cyclooxygenase-2 (COX-2) and its product, prostaglandin E2... -
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- Superoxide Anion Generation of Neutrophils in Patients with Atopic Dermatitis
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Yeo UC, Kim SH
- KMID: 1920688
- Korean J Dermatol.
- 1990 Dec;28(6):669-676.
Atopic dermatitis is characterized by many signs of immunodeficiency. We have performed this experiment to know whether there are reduced respiratoty burst of neutrophils in patients with atopic dermatitis in... -
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- The effect of rebamipide on cellular release of leukotriene B4 by Helicobacter pylori
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Lee JJ, Han BG, Ro JY, Rhee KH, Youn HS, Kim MN, Chung MH
- KMID: 2285201
- Korean J Physiol Pharmacol.
- 1997 Dec;1(6):825-830.
Leukotrienes (LTs) are known to act as a mediator provoking tissue response in inflammation. This finding implicates that LTs also play important roles in the pathogenesis of H. pylori-induced gastritis and gastric ulceration.... -
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- Increased inflammatory mediator in exhaled breath condensate from asthmatic children
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Han YK, Park JY, Kim MN, Kim YH, Park HB, Kim MJ, Lee KE, Lee HS, Heo WI, Hong JY, Kim KW, Sohn MH, Kim KE
- KMID: 1803539
- Allergy Asthma Respir Dis.
- 2014 Nov;2(5):332-336.
- doi: 10.4168/aard.2014.2.5.332
PURPOSE: There has recently been increasing interest in the use of exhaled breath condensate (EBC) as a simple noninvasive means for understanding the physiology of asthma. The aim of this... -
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- Effects of Transmigration of Bone Marrow Nuclear Cells Through Endothelial Cell and Stromal Cell by Leukotriene B4 and Inhibition of Reactive Oxygen Species
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Mun YC, Oh SA, Lee KE, Yoo ES, Choi MY, Ahn JY, Seong CM
- KMID: 2283926
- Ewha Med J.
- 2008 Sep;31(2):65-71.
- doi: 10.12771/emj.2008.31.2.65
OBJECTIVES: Leukotriene B4(LTB4) is lipid mediator derived from membrane phospholipids during the process of inflammation, having many roles(ie; inducer of chemotaxis, the production of nitric oxide, transepithelial migration of neutrophil).... -
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- Analysis of TMJ status in the patients with mandibular fractures: preliminary study arthroscopic examination, histomorphology and joint fluid analysis
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Kim YK, Kim HT, Lee DH, Choi YJ, Chung H
- KMID: 2328353
- J Korean Assoc Oral Maxillofac Surg.
- 2001 Aug;27(4):308-313.
The purpose of this study is to validate the potential etiologic factors for temporomandibular disorder(TMD). TMJ arthroscopic examination was performed in upper joint compartment of 32 joints from 20 patients... -
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- The Signaling Pathway of G-protein Rac and Eicosanoid Synthesis by Titanium Particles
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Lee SS, Her JY, Woo CH, Kim JH, Chang JD
- KMID: 2105760
- J Korean Orthop Assoc.
- 2001 Aug;36(4):317-325.
PURPOSE: In order to understand the intracellular signaling pathway involving the c-fos gene expression that is caused by Titanium-particles, we analyzed the involvement of Rac, cytosolic phospholipase A2, and eicosanoids... -
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- Effect of various cytokines on the production of prostaglandin E2 leukotriene B4 and collagenase in human periodontal ligament fibroblasts in vitro
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Kim JH, Suhr CH
- KMID: 1977083
- Korean J Orthod.
- 1994 Dec;24(4):871-883.
This experiment was designed to study possible roles of interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha in bone remodeling by measuring their effects on PGE2, LTB4 and collagenase production when they... -
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- The Protective Effect of Eupatilin against Hydrogen Peroxide-Induced Injury Involving 5-Lipoxygenase in Feline Esophageal Epithelial Cells
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Lim JC, Park SY, Nam Y, Nguyen TT, Sohn UD
- KMID: 1493963
- Korean J Physiol Pharmacol.
- 2012 Oct;16(5):313-320.
- doi: 10.4196/kjpp.2012.16.5.313
In this study, we focused to identify whether eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone), an extract from Artemisia argyi folium, prevents H2O2-induced injury of cultured feline esophageal epithelial cells. Cell viability was measured by... -
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- The Oral Therapy of Flavonoids Derivative DA-6034 in the Experimental Animal Models of Inflammatory Bowel Disease
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Kim YS, Kim TH, Jung HC, Song IS, Kim CY, Ko JI, Son MW, Kim WB
- KMID: 2084953
- Korean J Gastroenterol.
- 1999 Sep;34(3):317-329.
BACKGROUND/AIMS: Eupatilin, a kind of flavonoids, has been known to be effective for chronic diarrhea in Korea. We performed this study to evaluate the oral therapeutic effect of DA-6034, a... -
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