- Toward a grey box approach for cardiovascular physiome
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Hwang M, Leem CH, Shim EB
- KMID: 2455806
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):305-310.
- doi: 10.4196/kjpp.2019.23.5.305
The physiomic approach is now widely used in the diagnosis of cardiovascular diseases. There are two possible methods for cardiovascular physiome: the traditional mathematical model and the machine learning (ML)... -
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- A Computational Model of Cytosolic and Mitochondrial [Ca2+] in Paced Rat Ventricular Myocytes
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Youm JB, Choi SW, Jang CH, Kim HK, Leem CH, Kim N, Han J
- KMID: 1448927
- Korean J Physiol Pharmacol.
- 2011 Aug;15(4):217-239.
- doi: 10.4196/kjpp.2011.15.4.217
We carried out a series of experiment demonstrating the role of mitochondria in the cytosolic and mitochondrial Ca2+ transients and compared the results with those from computer simulation. In rat... -
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- Vesicular transport as a new paradigm in short-term regulation of transepithelial transport
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Park CS, Leem CH, Jang YJ, Shim YH
- KMID: 648112
- J Korean Med Sci.
- 2000 Apr;15(2):123-132.
- doi: 10.3346/jkms.2000.15.2.123
The vectorial transepithelial transport of water and electrolytes in the renal epithelium is achieved by the polarized distribution of various transport proteins in the apical and basolateral membrane. The short-term... -
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- A Novel Nicotinamide Adenine Dinucleotide Correction Method for Mitochondrial Ca2+ Measurement with FURA-2-FF in Single Permeabilized Ventricular Myocytes of Rat
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Lee JH, Ha JM, Leem CH
- KMID: 2285581
- Korean J Physiol Pharmacol.
- 2015 Jul;19(4):373-382.
- doi: 10.4196/kjpp.2015.19.4.373
Fura-2 analogs are ratiometric fluoroprobes that are widely used for the quantitative measurement of [Ca2+]. However, the dye usage is intrinsically limited, as the dyes require ultraviolet (UV) excitation, which... -
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- The Characteristics of Spontaneous Action Potential of Cardiac Myocytes in Rabbit Pulmonary Veins
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Choi KJ, Kim WT, Nam GB, Song JK, Kim JJ, Park SW, Park SJ, Park CH, Kim YH, Choi YS, Leem CH
- KMID: 2029540
- Korean Circ J.
- 2001 Jan;31(1):94-106.
- doi: 10.4070/kcj.2001.31.1.94
BACKGROUND AND OBJECTIVES: Atrial fibrillation is one of the most prevalent arrhythmia with clinical significance. Recently, some subset of paroxysmal atrial fibrillation was reported to be originated from a focal,... -
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- Cell-cell contacts via N-cadherin induce a regulatory renin secretory phenotype in As4.1 cells
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Chang JW, Kim S, Lee EY, Leem CH, Kim SH, Park CS
- KMID: 2534524
- Korean J Physiol Pharmacol.
- 2022 Nov;26(6):479-499.
- doi: 10.4196/kjpp.2022.26.6.479
The lack of a clonal renin-secreting cell line has greatly hindered the investigation of the regulatory mechanisms of renin secretion at the cellular, biochemical, and molecular levels. In the present... -
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- Role of Stretch-Activated Channels in Stretch-Induced Changes of Electrical Activity in Rat Atrial Myocytes
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Youm JB, Jo SH, Leem CH, Ho WK, Earm YE
- KMID: 1517035
- Korean J Physiol Pharmacol.
- 2004 Feb;8(1):33-41.
We developed a cardiac cell model to explain the phenomenon of mechano-electric feedback (MEF), based on the experimental data with rat atrial myocytes. It incorporated the activity of ion channels,... -
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- Potassium Currents in Isolated Deiters' Cells of Guinea Pig
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Chung JW, Nam EC, Kim WT, Youm JB, Leem CH
- KMID: 2285482
- Korean J Physiol Pharmacol.
- 2013 Dec;17(6):537-546.
- doi: 10.4196/kjpp.2013.17.6.537
Deiters' cells are the supporting cells in organ of Corti and are suggested to play an important role in biochemical and mechanical modulation of outer hair cells. We successfully isolated... -
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- Implication of phosphorylation of the myosin II regulatory light chain in insulin-stimulated GLUT4 translocation in 3T3-F442A adipocytes
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Choi YO, Ryu HJ, Kim HR, Song YS, Kim C, Lee W, Choe H, Leem CH, Jang YJ
- KMID: 1111411
- Exp Mol Med.
- 2006 Apr;38(2):180-189.
In adipocytes, insulin stimulates glucose transport primarily by promoting the translocation of GLUT4 to the plasma membrane. Requirements for Ca2+/ calmodulin during insulin-stimulated GLUT4 translocation have been demonstrated; however, the... -
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- Modeling of Arrhythmogenic Automaticity Induced by Stretch in Rat Atrial Myocytes
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Youm JB, Leem CH, Zhang YH, Kim N, Han J, Earm YE
- KMID: 1486109
- Korean J Physiol Pharmacol.
- 2008 Oct;12(5):267-274.
- doi: 10.4196/kjpp.2008.12.5.267
Since first discovered in chick skeletal muscles, stretch-activated channels (SACs) have been proposed as a probable mechano-transducer of the mechanical stimulus at the cellular level. Channel properties have been studied... -
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- Changes in the Rate of Renin Secretion During Cell Cycle of As 4.1 Cells
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Kim MK, Kim MH, Chang JW, Leem CH, Jang YJ, Park CS
- KMID: 2079304
- Korean J Nephrol.
- 2003 Sep;22(5):512-521.
BACKGROUND: Renin is secreted from the juxtaglomerular (JG) cells in response to a wide variety of extracellular stimuli. To study the underlying mechanism of regulation of renin secretion at molecular... -
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- Outward Rectifying Current in Isolated Deiters' Cells from Guinea Pig Cochlea
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Kim HJ, Ahn JH, Kim WT, Leem CH, Chung JW, Lee KS
- KMID: 1887269
- Korean J Otolaryngol-Head Neck Surg.
- 2002 Jun;45(6):550-556.
BACKGROUND AND OBJECTIVES: The Deiters' cell is one of the supporting cells in the organ of Corti and is known to possibly regulate the signal transduction pathway in the organ... -
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- The Effects of Neurotransmitters on the Ion Channels in the Isolated Deiters'Cells of Guinea Pig Cochlea
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Nam EC, Kim WT, Leem CH, Chung JW
- KMID: 1923102
- Korean J Otolaryngol-Head Neck Surg.
- 2003 Mar;46(3):191-197.
BACKGROUND AND OBJECTIVES: The supporting cells in the organ of Corti help to maintain the structural integrity of the organ, but it has been suggested that they also actively participate... -
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