- Clinical Utility and Reporting of Absence of Heterozygosity in Chromosomal Microarray Analysis
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Kim KB, Ha JS
- KMID: 2552755
- Lab Med Online.
- 2023 Oct;13(4):290-300.
- doi: 10.47429/lmo.2023.13.4.290
With the widespread use of chromosomal microarray (CMA) testing in Korea, the chances for laboratories to detect the absence of heterozygosity (AOH) are increasing. AOH detected by CMA can be... -
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- Detection of Mosaic Sequence Variants Associated with Human Genetic Diseases
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Kim MJ, Lee JS, Seong MW
- KMID: 2552754
- Lab Med Online.
- 2023 Oct;13(4):282-289.
- doi: 10.47429/lmo.2023.13.4.282
Mosaicism refers to cells with different genetic makeups within a single zygote. Although relatively common, the frequency of mosaicism is often underestimated, particularly in low-grade cases, due to limitations in... -
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- Clinical Significance of MUTYH Germline Variant
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Ryu KH, Kang MC, Jung YR, Jang MA, Park JE, Kim N, Won D, Park B, Kong SY
- KMID: 2552756
- Lab Med Online.
- 2023 Oct;13(4):301-307.
- doi: 10.47429/lmo.2023.13.4.301
The MUTYH germline pathogenic variant is known to increase the risk of polyposis and colorectal cancer with a recessive mode of inheritance. However, the risks of other cancers caused by... -
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- Technical Considerations and Miscellaneous Findings on Electrophoretograms of Serum Protein Capillary Electrophoresis
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Kim HK, Park SH, Lim JH, Jeong J, Lee SH
- KMID: 2552752
- Lab Med Online.
- 2023 Oct;13(4):263-274.
- doi: 10.47429/lmo.2023.13.4.263
The use of the serum protein capillary electrophoresis (CE) is prevalent in clinical laboratories owing to its greater feasibility for automation compared with the gel-based methods. Compared with the traditionally... -
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- Application of the Analytical Performance Specification for Quality Management of Clinical Chemistry Tests
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Yim J, Rim hH, Lim YK, Cho Y, Park Y, Kim S, Yun YM
- KMID: 2552751
- Lab Med Online.
- 2023 Oct;13(4):255-262.
- doi: 10.47429/lmo.2023.13.4.255
In the realm of clinical laboratories, the implementation of a quality management system is vital for the quality management of various test results for patient treatment. Analytical performance specifications (APS)... -
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- Survey on the Implementation of Delta Checks and Panic Values in Immunoassays in Korea
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Lee H, Shin KH, Kim S, Yoo SJ, Yu S
- KMID: 2552759
- Lab Med Online.
- 2023 Oct;13(4):324-331.
- doi: 10.47429/lmo.2023.13.4.324
Background: This study aimed to inquire about the implementation of delta checks and panic values for immunoassays in clinical laboratories through an online survey. Methods: A questionnaire survey was conducted on... -
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- Overcoming Immunological Barriers in Xenotransplantation: A Historical Review of Previous Research and Future Directions
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Kang HJ
- KMID: 2552753
- Lab Med Online.
- 2023 Oct;13(4):275-281.
- doi: 10.47429/lmo.2023.13.4.275
The shortage of human donor organs is a major concern in clinical transplantation. Xenotransplantation, the transplantation of animal organs into humans, is a procedure that aims to solve this problem.... -
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- Current Status of BCR::ABL1 Quantitative PCR Analysis in Korea (2022)
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Lee JY, Kim IS, Kim HY, Shin S, Kim M
- KMID: 2552763
- Lab Med Online.
- 2023 Oct;13(4):356-363.
- doi: 10.47429/lmo.2023.13.4.356
Background: BCR::ABL1 real-time quantitative PCR (RQ-PCR) is the optimal test for monitoring patients with chronic myeloid leukemia after treatment; however, standardization among testing institutions is required to assess molecular response.... -
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- Comparison Between Two Different Second-Generation Parathyroid Hormone Assays
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Kang JK, Jeon JH, Park JH, Kee SJ, Choi HW
- KMID: 2552760
- Lab Med Online.
- 2023 Oct;13(4):332-340.
- doi: 10.47429/lmo.2023.13.4.332
Background: Accurate measurement of parathyroid hormone (PTH) levels is crucial for the diagnosis and treatment of hyperparathyroidism and hypoparathyroidism. Given the existence of various PTH forms in the bloodstream, it... -
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- A Case of Chronic Myeloid Leukemia with Micro BCR::ABL1 Rearrangement: Precaution in Reverse Transcription PCR to Prevent False Negativity
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Kim SW, Kim H, Shin S, Chung H
- KMID: 2552765
- Lab Med Online.
- 2023 Oct;13(4):370-374.
- doi: 10.47429/lmo.2023.13.4.370
We report a patient negative for BCR::ABL1 in qualitative reverse transcription (RT)-PCR but subsequently reported to be positive for t(9;22) (q34;q11.2) in conventional karyotyping. The patient was finally diagnosed... -
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- Correlation between Clinical Severity and Cycle Threshold Values of Real-time RT-PCR at the Time of Admission in COVID-19 Patients
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Yoo EH, Lee AJ, Kim SG, Jeon CH
- KMID: 2552764
- Lab Med Online.
- 2023 Oct;13(4):364-369.
- doi: 10.47429/lmo.2023.13.4.364
Background: The viral load of the patient can be deduced from the cycle threshold (Ct) value. In this study, the correlation between the initial Ct value of the SARS-CoV-2 real-time... -
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- Evaluation of Two Safety Syringes for Arterial Blood Gas Analysis
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Kim A, Lee S, Kim S, Lee W, Chun S, Min WK
- KMID: 2552757
- Lab Med Online.
- 2023 Oct;13(4):308-317.
- doi: 10.47429/lmo.2023.13.4.308
Background: Arterial blood gas (ABG) analysis is a crucial test providing vital information for patients who are critically ill. Accurate results are essential; however, pre-implementation evaluation of ABG syringes is... -
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- Performance Evaluation of Access HIV Combo V2 Assay
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Lee H, Choi YJ, Song EY
- KMID: 2552761
- Lab Med Online.
- 2023 Oct;13(4):341-348.
- doi: 10.47429/lmo.2023.13.4.341
Background: The recently introduced 4th generation HIV assay, Access HIV Combo V2 (Bio-Rad Laboratories, USA), can detect the HIV-2 p26 antigen, which has not been targeted by other 4th generation... -
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- Diagnostic Performance of Hepatic Steatosis Algorithms in Korean Population with Metabolic-Associated Fatty Liver Disease
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Park KJ
- KMID: 2552758
- Lab Med Online.
- 2023 Oct;13(4):318-323.
- doi: 10.47429/lmo.2023.13.4.318
Background: The new nomenclature of metabolic-associated fatty liver disease (MAFLD) has been proposed to describe fatty liver condition associated with metabolic dysfunction. Currently, hepatic steatosis indices for predicting MAFLD have... -
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- Establishing a Reference Interval for Flow Cytometry-Based NK Activity (FC-NKA) Assay in Healthy Korean Population
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Kang H, Choi AR, Ryu JH, Oh EJ
- KMID: 2552762
- Lab Med Online.
- 2023 Oct;13(4):349-355.
- doi: 10.47429/lmo.2023.13.4.349
Background: Flow cytometry (FC)-based natural killer cell activity (NKA) assays are commonly used in clinical laboratories. As low or no NKA is indicative of hemophagocytic lymphohistiocytosis (HLH), the precise determination... -
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