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Improvement plans on the operation of the Institutional Animal Care and Use Committee: focusing on the case of Seoul National University

Ahn N, Park J, Ihm J, Roh S

Background: The Institutional Animal Care and Use Committee (IACUC) became compulsory in 2008 by the Animal Protection Act in Korea. Seoul National University (SNU), which conducts 5% of Korea’s total...
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Anticancer effects of metformin in experimental animal models of different types of cancer: a systematic review and meta-analysis

Zhang F, Han S, Song W

To systematically evaluate the effects of metformin on tumors in experimental animal models of different types of cancer. Pubmed, Embase, Cochrane, and Web of Science databases were searched for studies...
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Researchers, animal support and regulatory staff: symbiosis or antagonism?

Tsang B, Gerlai R

Animals are studied en masse by biologists around the world in a variety of biomedical and basic research studies. All this research benefits humankind and animals alike as it tackles...
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Role of animal models in biomedical research: a review

Mukherjee P, Roy S, Ghosh D, Nandi SK

The animal model deals with the species other than the human, as it can imitate the disease progression, its’ diagnosis as well as a treatment similar to human. Discovery of...
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Impact of transit time on the reproductive capacity of Euprymna scolopes as a laboratory animal

Cecere AG, Miyashiro TI

Background: The Hawaiian bobtail squid Euprymna scolopes hosts various marine bacterial symbionts, and these symbioses have served as models for the animal-microbe relationships that are important for host health....
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Endotracheal intubation in rabbits using a video laryngoscope with a modified blade

Kim Y, Jeon HY, Yang I, Kim JH, Chung JH, Ju JH, Kim G, Park JW, Oh SY, Seong JK, Oh SH, Joo YS

Rabbits are being increasingly used as companion animals, and in research; thus, the need for proper veterinary care for rabbits has increased. Surgical access is more challenging in rabbits under...
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Humulus japonicus attenuates LPS-and scopolamine-induced cognitive impairment in mice

Go J, Park HY, Lee DW, Maeng SY, Lee IB, Seo YJ, An JP, Oh WK, Lee CH, Kim KS

Background: Neuroinflammation plays an important role in cognitive decline and memory impairment in neurodegenerative disorders. Previously, we demonstrated that Humulus japonicus (HJ) has anti-inflammatory effects in rodent models of Alzheimer’s...
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Comparative analysis of imaging diagnostic models for tubular basophilia and mineralization of kidney

Byun JS, Lee JH, Kang JS, Han BS

Background: Now that it is possible to efficiently classify and save tissue images of laboratory animals using wholeslide imaging, many diagnostic models are being developed through transfer learning with Convolutional...
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Effects of prebiotics in combination with probiotics on intestinal hydrolase activity, microbial population and immunological biomarkers in SD rats fed an AIN-93G diet

Kim MJ, Jeon DG, Lim Y, Jang I

Background: Gastrointestinal microbiota, which comprises hundreds of different types of microbes, biologically plays crucial roles in the host’s health. Probiotics (PRO) did not always have a positive benefit on the...
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Elucidating the characteristics of Mx1 and resistance to influenza A virus subtype H1N1 in the newly developed KWM/Hym mice

Nam H, Kim B, Gautam A, Kim YY, Park ES, Lee JS, Kwon HJ, Seong JK, Suh JG

Background: Inbred mice have several advantages, including genetic similarity to humans, a well-established gene manipulation system, and strong tolerance to inbreeding. However, inbred mice derived from a limited genetic pool...
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Ventilator-induced lung injury results in oxidative stress response and mitochondrial swelling in a mouse model

Joelsson JP, Asbjarnarson A, Sigurdsson S, Kricker J, Valdimarsdottir B, Thorarinsdottir H, Starradottir E, Gudjonsson T, Ingthorsson S, Karason S

Background: Mechanical ventilation is a life-saving therapy for critically ill patients, providing rest to the respiratory muscles and facilitating gas exchange in the lungs. Ventilator-induced lung injury (VILI) is an...
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Calcium carbide–induced derangement of hematopoiesis and organ toxicity ameliorated by cyanocobalamin in a mouse model

Ouma PA, Mwaeni VK, Amwayi PW, Isaac AO, Nyariki JN

Background: Calcium carbide (CaC 2 ) is a chemical primarily used in the production of acetylene gas. The misuse of CaC 2 to induce fruit ripening is a global challenge...
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