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In Vivo Stem Cell Imaging Principles and Applications

Hong S, Lee DS, Bae GW, Jeon J, Kim HK, Rhee S, Jung KO

Stem cells are the foundational cells for every organ and tissue in our body. Cell-based therapeutics using stem cells in regenerative medicine have received attracting attention as a possible treatment...
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Corrigendum to “Cyclic Phytosphingosine-1-Phosphate Primed Mesenchymal Stem Cells Ameliorate LPS-Induced Acute Lung Injury in Mice”

Park Y, Jang J, Lee J, Baek H, Park J, Cha SR, Lee SB, Na S, Kwon JW, Park YJ, Choi MJ, Kim KS, Hong SH, Yang SR

  • KMID: 2548008
  • Int J Stem Cells.
  • 2023 Nov;16(4):448-449.
  • doi: 10.15283/23001C
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Differentiation and Characterization of Cystic Fibrosis Transmembrane Conductance Regulator Knockout Human Pluripotent Stem Cells into Salivary Gland Epithelial Progenitors

Yan S, Zhang Y, Zhang S, Wei S

The differentiation of pluripotent stem cells has been used to study disease mechanisms and development. We previously described a method for differentiating human pluripotent stem cells (hPSCs) into salivary gland...
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Preclinical Study on Biodistribution of Mesenchymal Stem Cells after Local Transplantation into the Brain

Bashyal N, Kim MG, Jung JH, Acharya R, Lee YJ, Hwang WS, Choi JM, Chang DY, Kim SS, Suh-Kim H

Therapeutic efficacy of mesenchymal stem cells (MSCs) is determined by biodistribution and engraftment in vivo. Compared to intravenous infusion, biodistribution of locally transplanted MSCs are partially understood. Here, we performed a...
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RNF43 and ZNRF3 in Wnt Signaling - A Master Regulator at the Membrane

Farnhammer F, Colozza G, Kim J

The Wnt β-catenin signaling pathway is a highly conserved mechanism that plays a critical role from embryonic development and adult stem cell homeostasis. However, dysregulation of the Wnt pathway has...
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Low-Intensity Pulsed Ultrasound Promotes BMP9 Induced Osteoblastic Differentiation in Rat Dedifferentiated Fat Cells

Setoguchi F, Sena K, Noguchi K

Dedifferentiated fat cells (DFATs) isolated from mature adipocytes have a multilineage differentiation capacity similar to mesenchymal stem cells and are considered as promising source of cells for tissue engineering. Bone...
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Assessment of Risks and Benefits of Using Antibiotics Resistance Genes in Mesenchymal Stem Cell-Based Ex-Vivo Therapy

Bashyal N, Lee YJ, Jung JH, Kim MG, Lee KW, Hwang WS, Kim SS, Chang DY, Suh-Kim H

Recently, ex-vivo gene therapy has emerged as a promising approach to enhance the therapeutic potential of mesenchymal stem cells (MSCs) by introducing functional genes in vitro. Here, we explored the...
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Transcriptional Signature of Valproic Acid-Induced Neural Tube Defects in Human Spinal Cord Organoids

Lee JH, Shaker MR, Park SH, Sun W

In vertebrates, the entire central nervous system is derived from the neural tube, which is formed through a conserved early developmental morphogenetic process called neurulation. Although the perturbations in neurulation...
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Adipose Tissue-Derived Mesenchymal Stromal Cells from Ex-Morbidly Obese Individuals Instruct Macrophages towards a M2-Like Profile In Vitro

Alves DVL, Claudio-da-Silva C, Souza MCA, Pinho RT, Silva WSd, Sousa-Vasconcelos PS, Borojevic R, Nogueira CM, Dutra HdS, Takiya CM, Bonfim DC, Rossi MID

Obesity, which continues to increase worldwide, was shown to irreversibly impair the differentiation potential and angiogenic properties of adipose tissue mesenchymal stromal cells (ADSCs). Because these cells are intended for...
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