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The Role of the Insulin-like Growth Factors and Insulin-like Growth Factor Binding Proteins in Growth Disorders

Kim HS

  • KMID: 1515259
  • J Korean Soc Endocrinol.
  • 2003 Dec;18(6):543-551.
No abstract available.
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Characterization of insulin-like growth factor binding proteins in chronic renal failure

Lee DY, Yang DH, Park SK

  • KMID: 1694548
  • Korean J Nephrol.
  • 1993 Sep;12(3):343-351.
No abstract available.
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Insulin-like growth factor (IGF)-I and IGF binding proteins axis in diabetes mellitus

Kim MS, Lee DY

Increasing evidence suggests an important role of the insulin-like growth factor (IGF)-IGF binding protein (IGFBP) axis in the maintenance of normal glucose and lipid metabolism. Significant changes occur in the...
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Hepatocellular Carcinoma with Severe Hypoglycemia: Involvement of Insulin-ike Growth Factor I, II and Insulin-ike Growth Factor Binding Proteins

Kim SJ, Yun BY, Choi HC

  • KMID: 1832164
  • Korean J Hepatol.
  • 1999 Dec;5(4):332-337.
We report a case of hepatocellular carcinoma presented with severe hypoglycemia. Computerized tomography and ultrasonography revealed a massive bilateral tumor with portal vein thrombosis. The levels of IGF-I (113 ng/mL) and IGFBP-...
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Serum Insulin-like Growth Factor-1(IGF-1) and Insulin-like Growth Factor Binding Proteins in Hyperthyroidism and Hypothyroidism

Song HM, Park SS, Park TS, Baek HS, Lee DY

  • KMID: 2461604
  • J Korean Soc Endocrinol.
  • 1996 Mar;11(1):52-60.
Backgrounds: Thyroid hormones play a fundamental role in the initiation and maintenance of somatic growth in mammalian species, and the insulin-like growth factors(IGFs) occupy a position of central importance in...
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Biological roles of insulin-like growth factor binding proteins (IGFBPs)

Kim HS, Rosenfeld , Oh YM

  • KMID: 2045603
  • Exp Mol Med.
  • 1997 Jun;29(2):85-96.
The insulin-like growth factor binding protein (IGFBP) family is a critical component of the insulin-like growth factor (IGF) system which regulate the biological actions of the IGFs and may also...
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The Effect of 17beta- Estradiol on the Messenser Ribonucleic Acid ( mRNA ) Expression of Insulin-like Growth Factor Binding Proteins in Normal Myometrium and Uterine Leiomyoma

Kim SS, Kim JK, Lee JY

  • KMID: 1855595
  • Korean J Obstet Gynecol.
  • 1998 Jan;41(1):17-27.
Uterine leiomyoma is the most common female reproductive tract tumor during reproductive years. Estrogen has been implicated the most important factor in leimyoma growth. Recently studies have also implicated insulin-like...
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Alteration of Serum Insulin-like Growth Factor(IGF)-I and IGF-Binding Protein-2 in Healthy Population with Aging

Yoon KC, Lee DY

  • KMID: 2193909
  • J Korean Soc Pediatr Endocrinol.
  • 1998 May;3(1):7-12.
PURPOSE:Insulin-like growth factors, IGF- I and IGF-II, are proteins that promote cellular growth and differentiation of the various organs including the kidney. These peptides circulate in serum bound to...
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Recent Insights into Insulin-Like Growth Factor Binding Protein 2 Transcriptional Regulation

Shin M, Kang HS, Park JH, Bae JH, Song DK, Im SS

Insulin-like growth factor binding proteins (IGFBPs) are major regulators of insulin-like growth factor bioavailability and activity in metabolic signaling. Seven IGFBP family isoforms have been identified. Recent studies have shown...
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Levels of Insulin - like Growth Factor 1 ( IGF - 1 ) , Insulin - like Growth Factor Binding Protein 3 ( IGFBP - 3 ) , Osteocalcin and Deoxypyridinoline biochemical markers in either surgical menopause or natural menopause women

Chough SY, Kim SK, Lee JK

  • KMID: 2261326
  • Korean J Obstet Gynecol.
  • 1999 Feb;42(2):382-387.
OBJECTIVE: The purpose of this study was to investigate possible menopause related changes in circulating insulin-like growth factor binding protein 3 (IGFBP-3) levels and their relationship with insulin-like growth factor...
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Insulin-Like Growth Factor Binding Proteins Profiles in Sera of Patients with Uterine Myoma Before and After Hystrectomy

Noh KR, Kim JK

  • KMID: 2260954
  • Korean J Obstet Gynecol.
  • 1998 May;41(5):1273-1283.
It has been suggested that insulin-like growth factor (IGF) system plays an pivotal role in the growth of uterine myoma. Recent reports have shown that serum IGF-I levels are normal...
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Characteristics of Insulin-Like Growth Factor I in Serum; Pattern of Insulin-Like Growth Factor Binding Protein(Large Complex) in Short Stature Patients with Complete Growth Hormone Deficiency

Park JN, Seo BD, Shin JH, Moon SJ, Chang SY

  • KMID: 2208414
  • J Korean Pediatr Soc.
  • 1994 Nov;37(11):1548-1558.
To elucidate the complex of insulin-like growth factor binding proteins (IGF-BPs) in short stature patients, we carried out a prospective study on three patients who were diagnosed as complete GH...
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Influence of Activin and Follistatin on Expression of Insulin-like Growth Factor (IGF)-I, II, Insulin-like Growth Factor Binding Protein (IGFBP)-1, 2, and 3 mRNA in Cultured Mouse Granulosa Cells

Chae HD, Hong SH, Cho YH, Oh YM, Lee BH, Kim SH, Kim CH, Kang BM

  • KMID: 2076847
  • Korean J Obstet Gynecol.
  • 2003 Mar;46(3):592-599.
OBJECTIVE: To investigate the influence of activin and follistatin on the expression of IGF (insulin-like growth factor)-I, II, IGFBP (insulin-like growth factor binding protein)-1, 2, and 3 mRNA in cultured...
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The Role of Insulin-like Growth Factor I(IGF-I), and IGF Binding Protein (IGFBP) in Mouse Lung Cancer Cells

Cho CH, Kim SK, Kwak SM, Chang J, Kim SK, Chung KY

BACKGROUND: IGF-I is an important mitogen in many types of malignancies. Tumors also express many IGF binding proteins, which modulate IGF action. The purpose of this study was to evaluaste...
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Insulin-Like Growth Factors and Their Bindign Proteins in Uterine Leiomyoma Pretreated with Gonadtropin Releasing Hormone Agonist

Kim KC, Kim JG, Lee JY

  • KMID: 1999282
  • J Korean Soc Endocrinol.
  • 1997 Sep;12(3):364-375.
BACKGROUND: Uterine leiomyoma is the most common pelvic tumor, occurring in 20-25% of women in reproductive age. Gonadotropin releasing hormone agonist (GnRHa) has been reognized as a temporary medical management...
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The Expression of Insulin-like Growth Factor (IGF), IGF- Binding Protein (IGFBP) and the Role of IGFBP-3 in the Korean Gastric Cancer Cell Lines

Lee DY, Yi HK, Yang DH, Hwang PH

  • KMID: 2174986
  • J Korean Cancer Assoc.
  • 2001 Apr;33(2):121-129.
PURPOSE: Insulin-like growth factor (IGF)-I and II are potent mitogens, postulated to exert autocrine and paracrine effects on growth regulation in human gastric cancer. In this study, we evaluated the...
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The Effects of a Gonadotropin Releasing Hormone agonist on Insulin-like Growth Factor Binding Proteins(IGFBPs) Production in Explant Cultures of Human Uterine Myoma and Normal Myometrium

Kim JG, Suh CS, Kim SH, Choi YM, Moon SY, Lee JY

  • KMID: 2260784
  • Korean J Obstet Gynecol.
  • 1997 Apr;40(4):758-766.
Gonadotropin releasing hormone agonist(GnRHa) has been used as a temporaruy medical management for uterine myoma. Insulin-like growth factors(IGFs) has been supposed to play an etiological role in myoma growth and...
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The Effect of Sex Steroid Hormone on the Expression of Insulin-Like Growth Factor Binding Preteins mRNA in the Explant Cultured from Human Uterine Myoma and Adjacent Normal Myometrium

Lee JY, Kim JK, Seo CS, Kim SH, Choi YM, Moon SY

  • KMID: 1853224
  • J Korean Soc Endocrinol.
  • 1998 Mar;13(1):34-44.
BACKGROUND: Sex steroid hormones are believed to play an important role in the genesis and growth of uterine myoma. Several studies suggest a possible role of insulin-like growth factor(IGF) as...
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The levels of insulin-like growth factor-binding proteins and their protease activity in serum and follicular fluid during the controlled ovarian hyperstimulation cycle

Kim JG, Suh CS, Kim SH, Choi YM, Moon SY, Lee YH, Lee JY

  • KMID: 2269998
  • Korean J Obstet Gynecol.
  • 2000 Mar;43(3):488-496.
OBJECTIVES: To evaluate changes in serum insulin-like growth factor binding protein(IGFBP)s profiles during the controlled hyperstimulation cycle and to compare IGFBPs profiles and their protease activity in follicular fluid(FF) from polycystic ovary...
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Insulin-like Growth Factor Binding Proteins(IGFBPs) Profiles in CordSera of Appropriate-for gestational Age, Small-for-gestational Age,Large-for-gestational Age Infant and Preterm Infant

Kim JG, Ku SY, Kim SH, Choi YM, Shin CJ, Moon SY, Lee JY

  • KMID: 2271653
  • Korean J Obstet Gynecol.
  • 1997 Mar;40(3):581-590.
The insulin-like growth factor(IGF) system consists of IGFs, their receptor and binding proteins(IGFBPs). The IGFs are important growth factors in the regulation of fetal growth. Since IGFBPs control IGF actions,...
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