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Insulin-like growth factor (IGF)-I and IGF binding proteins axis in diabetes mellitus

Kim MS, Lee DY

Increasing evidence suggests an important role of the insulin-like growth factor (IGF)-IGF binding protein (IGFBP) axis in the maintenance of normal glucose and lipid metabolism. Significant changes occur in the...
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Serum Insulin-like Growth Factor-1(IGF-1) and Insulin-like Growth Factor Binding Proteins in Hyperthyroidism and Hypothyroidism

Song HM, Park SS, Park TS, Baek HS, Lee DY

  • KMID: 2461604
  • J Korean Soc Endocrinol.
  • 1996 Mar;11(1):52-60.
Backgrounds: Thyroid hormones play a fundamental role in the initiation and maintenance of somatic growth in mammalian species, and the insulin-like growth factors(IGFs) occupy a position of central importance in...
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The Effect of 17beta- Estradiol on the Messenser Ribonucleic Acid ( mRNA ) Expression of Insulin-like Growth Factor Binding Proteins in Normal Myometrium and Uterine Leiomyoma

Kim SS, Kim JK, Lee JY

  • KMID: 1855595
  • Korean J Obstet Gynecol.
  • 1998 Jan;41(1):17-27.
Uterine leiomyoma is the most common female reproductive tract tumor during reproductive years. Estrogen has been implicated the most important factor in leimyoma growth. Recently studies have also implicated insulin-like...
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Insulin-Like Growth Factor Binding Proteins Profiles in Sera of Patients with Uterine Myoma Before and After Hystrectomy

Noh KR, Kim JK

  • KMID: 2260954
  • Korean J Obstet Gynecol.
  • 1998 May;41(5):1273-1283.
It has been suggested that insulin-like growth factor (IGF) system plays an pivotal role in the growth of uterine myoma. Recent reports have shown that serum IGF-I levels are normal...
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Influence of Activin and Follistatin on Expression of Insulin-like Growth Factor (IGF)-I, II, Insulin-like Growth Factor Binding Protein (IGFBP)-1, 2, and 3 mRNA in Cultured Mouse Granulosa Cells

Chae HD, Hong SH, Cho YH, Oh YM, Lee BH, Kim SH, Kim CH, Kang BM

  • KMID: 2076847
  • Korean J Obstet Gynecol.
  • 2003 Mar;46(3):592-599.
OBJECTIVE: To investigate the influence of activin and follistatin on the expression of IGF (insulin-like growth factor)-I, II, IGFBP (insulin-like growth factor binding protein)-1, 2, and 3 mRNA in cultured...
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The levels of insulin-like growth factor-binding proteins and their protease activity in serum and follicular fluid during the controlled ovarian hyperstimulation cycle

Kim JG, Suh CS, Kim SH, Choi YM, Moon SY, Lee YH, Lee JY

  • KMID: 2269998
  • Korean J Obstet Gynecol.
  • 2000 Mar;43(3):488-496.
OBJECTIVES: To evaluate changes in serum insulin-like growth factor binding protein(IGFBP)s profiles during the controlled hyperstimulation cycle and to compare IGFBPs profiles and their protease activity in follicular fluid(FF) from polycystic ovary...
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Profile of Insulin, Growth Hormone and Insulin-like Growth Factors in Human Cord Blood According to Birth Weight

Kim HY, Lee DY, Cho SC

  • KMID: 2335376
  • J Korean Pediatr Soc.
  • 1998 Nov;41(11):1484-1490.
PURPOSE: Insulin-like growth factors (IGFs) are mitogenic peptides that are essential for fetal and maternal tissue growth during pregnancy. They circulate primarily with serum IGF-binding protein (IGFBP) which regulates the...
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Growth Status and Levels of Growth Factors in Children with Insulin-dependent Diabetes Mellitus

Chung SC, Kim DH

  • KMID: 2335360
  • J Korean Pediatr Soc.
  • 1998 Aug;41(8):1102-1110.
PURPOSE: It is well known that the linear growth velocity in children with insulin-dependent diabetes mellitus (type 1 DM) is closely related to metabolic control and onset age of the...
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Insulin-like Growth Factor(IGF)-I and IGF-Binding Protein-3 in Relation to Hemoglobin Concentration in Healthy Infants

Kang YK, Lee DY

  • KMID: 2335499
  • J Korean Pediatr Soc.
  • 2000 Jul;43(7):967-973.
PURPOSE: Insulin-like growth factor(IGF-I) and IGF binding protein(IGFBP)-3 is thought to play an important role in fetal erythropoiesis. The objective of this study was to establish a relation between IGF-I, free IGF-I,...
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Insulin-like Growth Factor Binding Proteins(IGFBPs) Profiles in CordSera of Appropriate-for gestational Age, Small-for-gestational Age,Large-for-gestational Age Infant and Preterm Infant

Kim JG, Ku SY, Kim SH, Choi YM, Shin CJ, Moon SY, Lee JY

  • KMID: 2271653
  • Korean J Obstet Gynecol.
  • 1997 Mar;40(3):581-590.
The insulin-like growth factor(IGF) system consists of IGFs, their receptor and binding proteins(IGFBPs). The IGFs are important growth factors in the regulation of fetal growth. Since IGFBPs control IGF actions,...
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Serum Insulin-like Growth Factors and their Binding Proteins in the Women With Polycystic Ovary

Roh JS, Yoo JB, Jo SH, Kim HS, Hwang YY

  • KMID: 2261935
  • Korean J Obstet Gynecol.
  • 2000 May;43(5):795-805.
OBJECTIVE: The involvement of IGF system in hyperandrogenism and abnormal follicular development is controversial. This study is to assess whether IGF system contribute to it in the women with polycystic ovary(PCO). METHODS:...
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The relationship between serum insulin - like growth factor binding proteins profiles and bone mineral density in women without ovarian function

Moon SY, Choi YM, Kim SH, Lee JY, Kim JG, Shin CS, Suh CS, Kim SY

  • KMID: 2261271
  • Korean J Obstet Gynecol.
  • 1999 Jan;42(1):125-131.
The insulin-like growth factor(IGF)s are believed to play an important role in the maintenance of bone mass. The IGFs are found complexed with high affinity to a family of IGF-binding...
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Influence of Tumor Necrosis Factor-alpha on Expression of Insulin-like Growth Factor-II, Insulin-like Growth Factor Binding Protein-1, 2, 3, 5 in Cultured Human Luteinized Granulosa Cells

Hong SH, Hong SH, Kim SH, Chae HD, Kim CH, Kang BM

  • KMID: 2013163
  • Korean J Obstet Gynecol.
  • 2006 Mar;49(3):633-643.
OBJECTIVE: To investigate the influence of tumor necrosis factor (TNF)-alpha on the expression of insulin-like growth factor (IGF)-II, insulin-like growth factor binding protein (IGFBP)-1, 2, 3, and 5 mRNA in...
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The Correlation of Ovarian Follicular Concentrations of IGF-II, IGFBP-1, and 3 between Cumulative Embryo Score in Patients Undergoing IVF-ET

Kwon HE, Hong SH, Park CY, Kim SH, Chae HD, Kim CH, Kang BM, Nam JH

  • KMID: 2272039
  • Korean J Obstet Gynecol.
  • 2003 May;46(5):970-977.
OBJECTIVE: To investigate the correlation between the concentrations of insulin-like growth factor-II (IGF-II), insulin-like growth factor binding protein-1, 3 (IGFBP-1, 3) in the follicular fluid and the cumulative embryo score...
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The Effect of Interleukin-1 on The Production of Insulin-Like Growth Factors and Their Binding Proteins in Human Granulosa-Luteal Cells

Lee JY, Min EG, Kim JK, Suh CS, Kim SH, Choi YM, Moon SY

  • KMID: 2261050
  • Korean J Obstet Gynecol.
  • 1998 Jul;41(7):1795-1804.
The relationship between the immune system and the endocrine system in the ovary has become of an challenging and exciting subject to reproductive scientists. The intraovarian regulators such as insulin-like...
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Effects of Glycemic Control on Growth and IGF-I, IGF-II, IGFBPs in Insulin dependent Diabetic Children

Kim DH, Rho KS, Chung SC

  • KMID: 2331682
  • J Korean Diabetes Assoc.
  • 1998 Sep;22(3):392-402.
BACKGROUND: It is well known that linear growth velocity in diabetic children is closely related to metabolic control and age of onset. Many studies demonstrated growth impairment in diabetic children...
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Transforming Growth Factor-alpha Regulation of Insulin-like Growth Factor-II, Insulin-like Growth Factor Binding Protein-1 and 3 secretion and Epidermal Growth Factor receptor expression in human luteinized granulosa cells

Kang EH, Hong SH, Cho JS, Kim SH, Chae HD, Kim CH, Kang BM, Nam JH

  • KMID: 2270618
  • Korean J Obstet Gynecol.
  • 2002 Dec;45(12):2130-2139.
OBJECTIVE: To investigate the effects of transforming growth factor (TGF)-alpha on insulin-like growth factor (IGF)-II, insulin-like growth factor binding protein (IGFBP)-1, and 3 secretion and epidermal growth factor (EGF) receptor...
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Serum IGF-I, Free IGF-I, IGFBP-1, IGFBP-3 Levels in Children with Intrauterine Growth Retardation

Hwang IT, Park EA, Kim GH, Kim HS

  • KMID: 2193796
  • J Korean Soc Pediatr Endocrinol.
  • 1999 Dec;4(2):186-194.
PURPOSE:Most but not all intrauterine growth retardation(IUGR) children has catch-up growth postnatally. However, nothing is known about the predictive parameters on the catch-up growth. The aim of this study was...
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The Effect of Obesity on Serum Growth Factors, and Insulin-like Growth Factor Binding Protein-3 Proteolysis in Children with Simple Obesity

Lee SW, Rhie YJ, Hwang IT, Han DK, Kim DH, Kim HS

  • KMID: 1838796
  • J Korean Soc Pediatr Endocrinol.
  • 2005 Dec;10(2):195-203.
PURPOSE: In children with simple obesity, spontaneous and stimulated growth hormone (GH) secretion are diminished, but their heights usually are normal or even taller for their age and sex. The...
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A Significance of Insulin-like Growth Factors (IGFs) and Insulin-like Growth Factor Binding Proteins (IGFBPs) in Ascites of Ovarian Cancer Patients

Lee KH, Kim KT, Hwang YY

  • KMID: 2245032
  • Korean J Gynecol Oncol Colposc.
  • 1998 Mar;9(1):44-54.
Based on the facts that expression of insulin-like growth factors(IGFs), their receptors, and insulin-like growth factor binding proteins(IGFBPs) have been found in many different types of malignancies including human ovarian...
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