- Cysteine-179 of I kappa B kinase beta plays a critical role in enzyme activation by promoting phosphorylation of activation loop serines
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Byun MS, Choi J, Jue DM
- KMID: 1098089
- Exp Mol Med.
- 2006 Oct;38(5):546-552.
I kappa B kinase beta (IKK beta) subunit of IKK complex is essential for the activation of NF-kappa B in response to various proinflammatory signals. Cys-179 in the activation loop... -
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- Emodin Isolated from Polygoni cuspidati Radix Inhibits TNF-alpha and IL-6 Release by Blockading NF-kappaB and MAP Kinase Pathways in Mast Cells Stimulated with PMA Plus A23187
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Lu Y, Jeong YT, Li X, Kim MJ, Park PH, Hwang SL, Son JK, Chang HW
- KMID: 2170660
- Biomol Ther.
- 2013 Nov;21(6):435-441.
Emodin, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, has several beneficial pharmacologic effects, which include anti-cancer, anti-diabetic, and anti-inflammatory activities. In this study, the authors examined the... -
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- Role of Insulin in the Activation of NF-kappaB/IkappaB Pathway in Macrophage Cells
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Lee SM, Jang YS, Lee CT, Kim YW, Han SK, Shim YS, Yoo CG
- KMID: 1728962
- Tuberc Respir Dis.
- 2010 Mar;68(3):168-174.
- doi: 10.4046/trd.2010.68.3.168
BACKGROUND: Sepsis still has a high mortality rate despite adequate supportive care. Newer therapeutic modalities have been developed but they have generally ended in failure. Recently, insulin was reported to... -
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- The Anti-Inflammatory Effect of Arginine-Vasopressin on Lipopolysaccharide-Induced IkappaBalpha/Nuclear Factor-kappaB Cascade
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Park J, Eo EY, Lee KH, Park JS, Lee JH, Yoo CG, Lee CT, Cho YJ
- KMID: 2227639
- Korean J Crit Care Med.
- 2015 Aug;30(3):151-157.
- doi: 10.4266/kjccm.2015.30.3.151
BACKGROUND: Arginine vasopressin (AVP) is widely used as a vasopressor agent. Some recent studies have suggested that AVP may exert an immunomodulatory effect. However, the mechanism about the anti-inflammatory effect... -
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- C-Terminal Serine Rich Region of IKK-beta Interacts with Bfl-1, a Homologue of Bcl-2
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Yoon HK, Kim JK, Cho HJ, Cho MY, Park YP, You KH, Kim JW, Yoon DY, Choe YK, Lee HG
- KMID: 2082800
- Korean J Lab Med.
- 2005 Jun;25(3):192-198.
BACKGROUND: Bcl-2 family proteins play a central role in regulating apoptosis. In human, over 20 members of this family have been identified to date. Bfl-1, a member of the Bcl-2... -
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- Interleukin-17 and Interleukin-22 Induced Proinflammatory Cytokine Production in Keratinocytes via Inhibitor of Nuclear Factor kappaB Kinase-alpha Expression
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Cho KA, Kim JY, Woo SY, Park HJ, Lee KH, Pae CU
- KMID: 2266033
- Ann Dermatol.
- 2012 Nov;24(4):398-405.
- doi: 10.5021/ad.2012.24.4.398
BACKGROUND: The pathogenesis of psoriasis may involve the interleukin (IL)-23 and Th17-mediated immune responses. Th17 cells secret IL-17 and IL-22, which mediates dermal inflammation and acanthosis. OBJECTIVE: As inhibitor of nuclear... -
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- The Role of NF-kappaB in Colon Cancer
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Seo GS
- KMID: 991461
- Korean J Gastroenterol.
- 2011 Jan;57(1):3-7.
- doi: 10.4166/kjg.2011.57.1.3
Colon cancer is the 3rd common malignancy and 4th common cause of cancer death in Korea. Recent studies have shown that abnormal inflammatory response plays a critical role in colon... -
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- The Common NF-kappaB Essential Modulator (NEMO) Gene Rearrangement in Korean Patients with Incontinentia Pigmenti
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Song MJ, Chae JH, Park EA, Ki CS
- KMID: 2157858
- J Korean Med Sci.
- 2010 Oct;25(10):1513-1517.
- doi: 10.3346/jkms.2010.25.10.1513
Incontinentia pigmenti (IP) is a rare X-linked dominant disorder characterized by highly variable abnormalities of the skin, eyes and central nervous system. A mutation of the nuclear factor-kappa B essential... -
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- Honokiol ameliorates endothelial dysfunction through suppression of PTX3 expression, a key mediator of IKK/IkappaB/NF-kappaB, in atherosclerotic cell model
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Qiu L, Xu R, Wang S, Li S, Sheng H, Wu J, Qu Y
- KMID: 2155425
- Exp Mol Med.
- 2015 Jul;47(7):e171.
- doi: 10.1038/emm.2015.37
Pentraxin 3 (PTX3) was identified as a marker of the inflammatory response and overexpressed in various tissues and cells related to cardiovascular disease. Honokiol, an active component isolated from the... -
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- A new synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), suppresses the Toll-like receptor 4-mediated inflammatory response through inhibition of the Akt/NF-kappaB pathway in BV2 microglial cells
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Lee YH, Jeon SH, Kim SH, Kim C, Lee SJ, Koh D, Lim Y, Ha K, Shin SY
- KMID: 1383799
- Exp Mol Med.
- 2012 Jun;44(6):369-377.
Microglial cells are the resident innate immune cells that sense pathogens and tissue injury in the central nervous system (CNS). Microglial activation is critical for neuroinflammatory responses. The synthetic compound... -
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- Incontinentia Pigmenti in a Newborn with NEMO Mutation
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Lee Y, Kim S, Kim K, Chang M
- KMID: 1782125
- J Korean Med Sci.
- 2011 Feb;26(2):308-311.
- doi: 10.3346/jkms.2011.26.2.308
Incontinentia pigmenti (IP) (OMIM #308300) is a rare X-linked dominant neuroectodermal multisystemic syndrome due to mutations in the gene for NF-kappaB essential modulator (NEMO). A term newborn girl who was... -
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- Transient exposure to hydrogen peroxide inhibits the ubiquitination of phosphorylated IkappaBalpha in TNFalpha-stimulated HEK293 cells
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Lee Y, Choi J, Ha KH, Jue DM
- KMID: 1387362
- Exp Mol Med.
- 2012 Aug;44(8):513-520.
During ischemia-reperfusion injury, brief pre-exposure to oxidative stress renders organs resistant to subsequent severe damage. NF-kappaB is a transcription factor that is involved in reperfusion-induced inflammatory and immune responses. The... -
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- Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract
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Kim SE, Thuy TT, Lee JH, Ro JY, Bae YA, Kong Y, Ahn JY, Lee DS, Oh YM, Lee SD, Lee YS
- KMID: 1088603
- Exp Mol Med.
- 2009 Apr;41(4):277-287.
- doi: 10.3858/emm.2009.41.4.031
Matrix metalloproteinase-9 (MMP-9) may play an important role in emphysematous change in chronic obstructive pulmonary disease (COPD), one of the leading causes of mortality and morbidity worldwide. We previously reported... -
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