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A Thermolabile Methylenetetrahydrofolate Reductaes (MTHFR) Gene Polymorphism is a Determinant of Hyperhomocysteinemia in the Elderly

Yoo JH

  • KMID: 2015020
  • J Korean Geriatr Soc.
  • 1999 Jun;3(1):34-40.
No abstract available.
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The Analysis of Methylenetetrahydrofolate Reductase Mutation in Recurrent Spontaneous Abortion Associated with Hyperhomocysteinemia

Nam YS, Choi JS, Ha KS, Lee ZW, Oh DY

  • KMID: 1891292
  • Korean J Fertil Steril.
  • 1999 Dec;26(3):441-446.
OBJECTIVE : To analyze the methylenetetrahydrofolate reductase (MTHFR) mutation in recurrent spontaneous abortion associated with hyperhomocysteinemia. MATERIAL AND METHOD: The blood Sample of habitual aborter with high fasting homocysteine level was...
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Vitamin B12 Deficiency with Extreme Hyperhomocysteinemia Presenting with a Brain Ischemic Lesion

Lee SM, Suh HI, Gil YE, Kwon HM, Lim TS

No abstract available.
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A Case of Pulmonary Thromboembolism in a Patient with Hyperhomocysteinemia

Oh SE, Jung JH, Yoon SB, Yoon HY, Park JK, Lee DH, Hong SH, Woo KH, Choi S, Lee SH, Lee N

Hyperhomocysteinemia is an independent risk factor for cardiovascular, cerebrovascular and peripheral vascular diseases that are complicated by atherosclerosis and a thromboembolism. An increased level of plasma homocysteine develops from a...
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Clinical Implication of Hyperhomocysteinemia in Chronic Renal Failure

Yoon KI

  • KMID: 2254448
  • Korean J Nephrol.
  • 2002 Jan;21(1):1-5.
No abstract available.
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Hyperhomocysteinemia in Patients Receiving Continuous Ambulatory Peritoneal Dialysis (CAPD)

Nah MY

  • KMID: 2275010
  • Chonnam Med J.
  • 2001 Jun;37(2):165-176.
We evaluated the prevalence and association of vascular complications and the determinents of hyperhomocysteinemia in predialysis patients receiving conservative treatment as well as CAPD. The prevalence of hyperhomocysteinemia was 83.8%,...
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A Case of Hyperhomocysteinemia Manifested by Deep Vein Thrombosis and Pulmonary Embolism

Lee SH, Choi SH, Lee JH, Seon KY, Joo SB

Homocysteine has been reported as an independent risk factor of intravascular thrombosis and atherosclerosis by its participation in vascular endothelial cell dysfunction, platelet activation and thrombus formation. The serum homocysteine...
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An Adolescent Ischemic Stroke Patient with Hyperhomocysteinemia, MTHFR 677TT and CBS 1080TT genotypes

Lee DH, Park CI, Lee IH, Lee JM, Kim SH, Lee JY, Lee SS, Choi BO

  • KMID: 1626913
  • J Korean Neurol Assoc.
  • 2005 Jun;23(3):382-385.
Hyperhomocysteinemia is an independent risk factor for cerebrovascular disease. Hyperhomocysteinemia can be caused by the defect of the remethylation pathway including the 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene or the transsulfuration...
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Perioperative stroke and hyperhomocysteinemia: a possible pathogenic link

Acampa M, Lazzerini , Martini G

No abstract available.
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A Case of Multiple Thromboembolisms in Hyperhomocysteinemia

Park JS, Bae WK, Lee SJ, Chung RI, Jin SL, Lee HP, Kim JI, Choi SJ, Yum HK

Hyperhomocysteinemia is an independent risk factor for cardiovascular, cerebrovascular and peripheral vascular diseases complicated with atherosclerosis and thromboembolism. Increased plasma homocystein level develops from genetic defect of enzyme for homocystein...
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Homozygous VN (677C to T) and d/D (2756G to A) variants in the methylenetetrahydrofolate and methionine synthase genes in a case of hyperhomocysteinemia with stroke at young age

Song KS, Song JW, Choi JR, Kim HK, Shin JS, Kim JH

  • KMID: 1085748
  • Exp Mol Med.
  • 2001 Jun;33(2):106-109.
Hyperhomocysteinemia is known to be associated with an increased risk of myocardial infarction, stroke, peripheral arterial disease, and venous thrombosis. Gene polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS)...
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The Effects of Hyperhomocysteinemia on the Ultrastructures of Cerebral Microvessels

Kim HJ, Kim YH, Chang NS, Lee HL, Lee HY

  • KMID: 2092784
  • Korean J Anat.
  • 2002 Jun;35(3):179-186.
Elevated plasma level of the sulfur amino acid homocysteine, termed hyperhomocysteinemia, is now recognized as a contributing factor to various pathological states of the brain including vascular, degenerative and other...
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Changes in Body Composition Predict Homocysteine Changes and Hyperhomocysteinemia in Korea

Park SB, Georgiades A

Cardiovascular disease (CVD) is the primary cause of death in Korea. Hyperhomocysteinemia confers an independent risk for CVD comparable to the risk of smoking and hyperlipidemia. The purpose of this...
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Association of Hyperhomocysteinemia and MTHFR Genotype in Parkinson's Disease

Yoo JH, Lee WY

  • KMID: 2338499
  • J Korean Geriatr Soc.
  • 2006 Sep;10(3):172-176.
BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) deficiency is rare in severe cases but common in mild cases. TT genotype of C677T of MTHFR shows reduced enzyme activity and hyperhomocysteinemia. It has been...
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Recurrent Stent Thrombosis and Pulmonary Thromboembolism Associated with Hyperhomocysteinemia

Kim MC, Jeong MH, Jang SY, Choi HS, Cho KH, Hwang SH, Lee MG, Park KH, Sim DS, Hong YJ, Kim JH, Ahn Y, Kang JC

Stent thrombosis is a fatal complication that can cause sudden cardiac death in patients implanted coronary stent. Also, pulmonary thromboembolism is associated with increased mortality. Usually, these vascular thromboembolic diseases...
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Pulmonary thromboembolism due to severe hyperhomocysteinemia associated with a methyltetrahydrofolate reductase mutation

Cho KH, Jeong MH, Sim DS, Hong YJ, Kim JH, Ahn Y, Kang JC

No abstract available.
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Prevalence and Determinants of Hyperhomocysteinemia in Patients with Chronic Renal Failure

Choi W, Kim JK, Park MJ, Park BS, Nah MY, Yeum CH, Kim SW, Choi KC, Kang YJ

  • KMID: 1989905
  • Korean J Nephrol.
  • 2000 Nov;19(6):1106-1114.
BACKGROUND: Hyperhomocysteinemia plays an important role in atherosclerosis resulting from endothelial dysfunction and injury followed by platelet activation and thrombus formation. We evaluated the prevalence and determinants of hyperhomocysteinemia in...
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Effects of Dietary Folate Supplementation on the Homocystine Diet-Induced Hyperhomocysteinemia and Hepatic S-Adenosylmethionine Metabolism in Rats

Kim JM, Lee HY, Chang N

  • KMID: 1618393
  • Korean J Nutr.
  • 2003 Oct;36(8):811-818.
We investigated the effects of dietary folate supplementation on plasma homocysteine, vitamin B12 and hepatic levels of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in diet-induced hyperhomocysteinemic rats. All animals were fed...
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Clinical Significance of Hyperhomocysteinemia Between Alzheimer's Disease and Vascular Dementia

Park HE, Cho HJ, Song IU, Chung SW

  • KMID: 2340256
  • J Korean Geriatr Soc.
  • 2013 Mar;17(1):41-46.
BACKGROUND: Recent research has shown that risk factors for cerebrovascular disorders are also causes of dementia. Of these risk factors, hyperhomocysteinemia is well known to be positively correlated with all...
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Brain Stem Infarction Due to Basilar Artery Dissection in a Patient with a Parotitis and Hyperhomocysteinemia

Ahn BJ

A 29-year-old man developed sudden dysarthria and right-sided weakness 3 days before admission to hospital. He was diagnosed with parotitis in the emergency room of Soonchunhyang University Gumi Hospital. The...
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