- The Effect of ABO Blood Groups, Hemoglobinopathy, and Heme Oxygenase-1 Polymorphisms on Malaria Susceptibility and Severity
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Kuesap J, Na-Bangchang K
- KMID: 2412735
- Korean J Parasitol.
- 2018 Apr;56(2):167-173.
- doi: 10.3347/kjp.2018.56.2.167
Malaria is one of the most important public health problems in tropical areas on the globe. Several factors are associated with susceptibility to malaria and disease severity, including innate immunity... -
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- Low Dose Carbon Monoxide Inhalation Prevents Chronic Allograft Nephropathy following Kidney Transplantation in Rats. Heme Oxygenase-1 Derivatives Study I
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Yoon M
- KMID: 2211161
- J Korean Surg Soc.
- 2008 May;74(5):323-329.
PURPOSE: Carbon monoxide (CO), a product of heme catalysis by heme oxygenase (HO-1, HO-2, HO-3), induces cytoprotection against ischemia/reperfusion (I/R) injury in a variety of organs such as the heart,... -
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- Change of Expression and Activity of Heme Oxygenase-1 in Rat Corpus Cavernosum during Low-flow Priapism
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Kim WJ, Jung HK, Jung JH, Kam SC, Hwa JS, Hyun JS
- KMID: 2298704
- Korean J Androl.
- 2004 Aug;22(2):81-86.
PURPOSE: The inducible isoform of heme oxygenase(HO), HO-1, responds to hypoxia. HO-1 regulates vascular smooth muscle tone through carbon monoxide production. To investigate the possible role of HO-1 in low-flow... -
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- Iron Contents in Rice Food Derived from the Iron Pot, and In Vitro Study Regarding Heme Oxygenase-1 Activity
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Kim KY, An YM, Kim TW, Jun YH, Lee JE, Jang JH, Kim SK
- KMID: 2358362
- Clin Pediatr Hematol Oncol.
- 2016 Oct;23(2):77-82.
- doi: 10.15264/cpho.2016.23.2.77
BACKGROUND: Iron pots have long been used for cooking in several countries. Early studies have shown that the use of such iron pots can increase the iron content of food... -
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- Modulation of Melanogenesis by Heme Oxygenase-1 via p53 in Normal Human Melanocytes
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Lim HS, Jin S, Yun SJ
- KMID: 2152655
- Chonnam Med J.
- 2016 Jan;52(1):45-52.
- doi: 10.4068/cmj.2016.52.1.45
As a key regulator of melanogenesis, p53 controls microphthalmia-associated transcription factor (MITF) and tyrosinase expression. The anti-oxidant enzyme heme oxygenase-1 (HO-1) is induced by various forms of cellular stress and... -
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- Vitamin D Improves Intestinal Barrier Function in Cirrhosis Rats by Upregulating Heme Oxygenase-1 Expression
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Wang PF, Yao DH, Hu YY, Li Y
- KMID: 2442015
- Biomol Ther.
- 2019 Feb;27(2):222-230.
- doi: 10.4062/biomolther.2018.052
Intestinal barrier dysfunction always accompanies cirrhosis in patients with advanced liver disease and is an important contributor facilitating bacterial translocation (BT), which has been involved in the pathogenesis of cirrhosis... -
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- Lithium ameliorates rat spinal cord injury by suppressing glycogen synthase kinase-3β and activating heme oxygenase-1
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Kim Y, Kim J, Ahn M, Shin T
- KMID: 2390482
- Anat Cell Biol.
- 2017 Sep;50(3):207-213.
- doi: 10.5115/acb.2017.50.3.207
Glycogen synthase kinase (GSK)-3β and related enzymes are associated with various forms of neuroinflammation, including spinal cord injury (SCI). Our aim was to evaluate whether lithium, a non-selective inhibitor of... -
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- Neuroprotective Effects of Betaxolol Mediated by Heme Oxygenase-1 Induction in RGC-5
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Cha JB, Kwon MY, Chung SW, Woo JM
- KMID: 2213854
- J Korean Ophthalmol Soc.
- 2016 Jan;57(1):113-119.
- doi: 10.3341/jkos.2016.57.1.113
PURPOSE: To evaluate the neuroprotective effects of betaxolol (betaxolol hydrochloride) under hypoxic conditions using retinal ganglion cells (RGC-5) and determine whether heme oxygenase-1 (HO-1) expression exerts cytoprotective effects. METHODS: In this... -
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- Isoegomaketone Upregulates Heme Oxygenase-1 in RAW264.7 Cells via ROS/p38 MAPK/Nrf2 Pathway
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Jin CH, So YK, Han SN, Kim JB
- KMID: 2351675
- Biomol Ther.
- 2016 Sep;24(5):510-516.
- doi: 10.4062/biomolther.2015.194
Isoegomaketone (IK) was isolated from Perilla frutescens, which has been widely used as a food in Asian cuisine, and evaluated for its biological activity. We have already confirmed that IK... -
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- The Anti-inflammatory Effect of Cobalt-Protoporphyrin for Rats with Epididymitis Induced by Escherichia coli Infection
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Seo IY, Jeong CS, Rim JS
- KMID: 2294243
- Korean J Urol.
- 2006 Jun;47(6):656-660.
- doi: 10.4111/kju.2006.47.6.656
PURPOSE: Heme oxygenase-1 (HO-1), an inducible heat shock protein, catalyzes the heme to iron, biliverdin and carbon monoxide. It also has an inhibitory effect on necrosis and inflammation. Cobalt (III)-protoporphyrin... -
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- Induction of Heme Oxygenase-1 by Traditional Herb Mix Extract Improves MKN-74 Cell Survival and Reduces Stomach Bleeding in Rats by Ethanol and Aspirin in vivo
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Kang YJ, Moon HS, Kim HJ, Seo HG, Lee JH, Chang KC
- KMID: 1512909
- Korean J Physiol Pharmacol.
- 2007 Apr;11(2):65-70.
Chinese herb medicines have traditionally been used to treat or alleviate the symptom of various diseases. The rationale for use of certain herbs to certain disorder is now getting unveiled... -
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- Gene expression of heme oxygenase-1 and nitric oxide synthase on trophoblast of preeclampsia
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Choi SK, Hwang JY, Lee J, Na SH, Ha JG, Lee HA, Lee DH
- KMID: 2274047
- Korean J Obstet Gynecol.
- 2011 Jul;54(7):341-348.
- doi: 10.5468/KJOG.2011.54.7.341
OBJECTIVE: The aim of this study was to evaluate the gene expression of heme oxygenase-1 (HO-1), inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) in placenta of... -
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- Combined Effect of High Intensity Exercise and (-) Epigallocatechin-3-gallate of Green Tea Supplementation on Heme Oxygenase-1 in the Large Intestine of SD Rats
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Choi SJ, Lee GW
- KMID: 2288626
- Korean J Sports Med.
- 2010 Jun;28(1):57-63.
The purpose of this study was to investigate effects of combined treatment with high intensity exercise and (-) epigallocatechin-3 gallate (EGCG), a potent free radical scavenger on a transcriptional level... -
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- Heme Oxygenase-1 is Involved in the Down-regulation of Nuclear Transcription Factor kappa B Activation in the Colonic Epithelium During Inflammation
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Yun KJ, Kim YR, Lee HJ, Kim KS, Kwon YM, Choi MK, Oh JM, Chung YT
- KMID: 2092854
- Korean J Anat.
- 2004 Dec;37(6):571-577.
Heme oxygenase-1 (HO-1) is a stress-inducible enzyme with anti-inflammatory activity, but the mechanisms underlying this activity are incompletely understood. Nuclear transcription factor kappa B (NF-kappa B) activation is an important... -
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- Effect of canine mesenchymal stromal cells overexpressing heme oxygenase-1 in spinal cord injury
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Lee SH, Kim Y, Rhew D, Kim A, Jo KR, Yoon Y, Choi KU, Jung T, Kim WH, Kweon OK
- KMID: 2412456
- J Vet Sci.
- 2017 Sep;18(3):377-386.
- doi: 10.4142/jvs.2017.18.3.377
Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that modulates the immune response and oxidative stress associated with spinal cord injury (SCI). This study aimed to investigate neuronal regeneration via transplantation... -
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- Protective Effects of Geniposide and Genipin against Hepatic Ischemia/Reperfusion Injury in Mice
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Kim J, Kim HY, Lee SM
- KMID: 1502515
- Biomol Ther.
- 2013 Mar;21(2):132-137.
Geniposide is an active product extracted from the gardenia fruit, and is one of the most widely used herbal preparations for liver disorders. This study examined the cytoprotective properties of... -
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- HO-1 Reduces the Severity of Trinitrobenzene Sulfonic Acid-induced Colitis through Suppression of NF-kappaB Activation
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Lee SP, Song JH, Jang SJ
- KMID: 1510216
- Korean J Anat.
- 2006 Dec;39(6):425-432.
Heme oxygenage-1 (HO-1), rate-limiting enzyme in heme catabolism, has been known to show strong immune-suppressive properties although its mechanisms are not completely understood. In this study, the authors investigated the... -
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- Effects of heme oxygenase-1 upregulation on isoproterenol-induced myocardial infarction
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Eltobshy S, Hussein AM, Elmileegy , Askar MH, Khater Y, Metias EF, Helal GM
- KMID: 2443608
- Korean J Physiol Pharmacol.
- 2019 May;23(3):203-217.
- doi: 10.4196/kjpp.2019.23.3.203
The present study was designed to examine the effect of heme oxygenase-1 (HO-1) induction by cobalt protoporphyrin (CoPP) on the cardiac functions and morphology, electrocardiogram (ECG) changes, myocardial antioxidants (superoxide... -
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- Mechanism of Amelioration of Cisplatin Nephrotoxicity by Procaine Treatment in Mice
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Ahn DW, Kim SR, Ha DH, Kim SH
- KMID: 1937597
- Korean J Anesthesiol.
- 2007 Mar;52(3):318-327.
- doi: 10.4097/kjae.2007.52.3.318
BACKGROUND: Procaine binds to DNA and reduces cisplatin nephrotoxicity, but the mechanism is poorly understood. We explored whether procaine amelioration of cisplatin nephrotoxicity was related to down-and/or up-regulation of inflammatory... -
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- Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice
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Shin TK, Kang MS, Lee HY, Seo MS, Kim SG, Kim CD, Lee WS
- KMID: 2071679
- Korean J Physiol Pharmacol.
- 2009 Jun;13(3):257-263.
- doi: 10.4196/kjpp.2009.13.3.257
This study aimed to investigate whether selective serotonin reuptake inhibitors (SSRIs) attenuate brain injury and facilitate recovery following photothrombotic cortical ischemia in mice. Male ICR mice were anesthetized and systemically... -
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