- Suppression of Autophagy and Activation of Glycogen Synthase Kinase 3beta Facilitate the Aggregate Formation of Tau
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Kim SI, Lee WK, Kang SS, Lee SY, Jeong MJ, Lee HJ, Kim SS, Johnson GV, Chun W
- KMID: 2285415
- Korean J Physiol Pharmacol.
- 2011 Apr;15(2):107-114.
- doi: 10.4196/kjpp.2011.15.2.107
Neurofibrillary tangle (NFT) is a characteristic hallmark of Alzheimer's disease. GSK3beta has been reported to play a major role in the NFT formation of tau. Dysfunction of autophagy might facilitate... -
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- Wnt and GSK3 Signaling Pathways in Bipolar Disorder: Clinical and Therapeutic Implications
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Muneer A
- KMID: 2378478
- Clin Psychopharmacol Neurosci.
- 2017 May;15(2):100-114.
- doi: 10.9758/cpn.2017.15.2.100
The neurobiology of bipolar disorder, a chronic and systemic ailment is not completely understood. The bipolar phenotype manifests in myriad ways, and psychopharmacological agents like lithium have long term beneficial... -
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- Effects of chronic alcohol exposure on ischemia–reperfusion-induced acute kidney injury in mice: the role of β-arrestin 2 and glycogen synthase kinase 3
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Wang L, Zhu Y, Wang L, Hou J, Gao Y, Shen L, Zhang J
- KMID: 2386967
- Exp Mol Med.
- 2017 Jun;49(6):e347.
- doi: 10.1038/emm.2017.76
Little is known about the effects of chronic alcohol intake on the outcome of acute kidney injury (AKI). Hence, we examined the effects of chronic alcohol intake on the development... -
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- Increased Glycogen Synthase Kinase-3beta mRNA Level in the Hippocampus of Patients with Major Depression: A Study Using the Stanley Neuropathology Consortium Integrative Database
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Oh DH, Park YC, Kim SH
- KMID: 2315889
- Psychiatry Investig.
- 2010 Sep;7(3):202-207.
OBJECTIVE: Glycogen synthase kinase-3beta (GSK-3beta) has become recognized as a broadly influential enzyme affecting diverse range of biological functions, including gene expression, cellular architecture, and apoptosis. The results of previous... -
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- Role of Glycogen Synthase Kinase-3 in Motor Neuronal Cell Death Mechanism of in Vitro Familial ALS Model (G94A, A4V mutant motoneuron)
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Koh SH, Kim J, Kim MH, Yu HJ, Kim M, Kim HJ, Lee KW, Kim SH
- KMID: 2343148
- J Korean Neurol Assoc.
- 2005 Apr;23(2):249-256.
BACKGROUND: G93A or A4V mutations in the human Cu/Zn- superoxide dismutase gene (hSOD1) cause familial amyotrophic lateral sclerosis (fALS). However, it has not yet clearly understood how these bring about... -
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- Glycogen Synthase Kinase 3 Inactivation Induces Cell Senescence through Sterol Regulatory Element Binding Protein 1-Mediated Lipogenesis in Chang Cells
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Kim YM, Song I, Seo YH, Yoon G
- KMID: 2169308
- Endocrinol Metab.
- 2013 Dec;28(4):297-308.
- doi: 10.3803/EnM.2013.28.4.297
BACKGROUND: Enhanced lipogenesis plays a critical role in cell senescence via induction of expression of the mature form of sterol regulatory element binding protein 1 (SREBP1), which contributes to an... -
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- The Role of Akt-1/PKBalpha on Insulin Action in 3T3-L1 Adipocyte
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Lee JM, Son HS, Kwon HS, Kwack SK, Ko SH, Chang SA, Yoon KH, Cha BY, Lee KW, Son HY, Kang SK, Sharma P
- KMID: 2177818
- J Korean Diabetes Assoc.
- 2002 Aug;26(4):274-285.
BACKGROUNDS: Akt/PKB as a serine/threonine kinase is stimulated by insulin and other growth factors. And insulin stimulates glucose uptake by promoting the translocation of glucose transporter 4 (GLUT4) to the... -
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- Potential involvement of glycogen synthase kinase (GSK)-3β in a rat model of multiple sclerosis: evidenced by lithium treatment
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Ahn M, Kim J, Park C, Cho J, Jee Y, Jung K, Moon C, Shin T
- KMID: 2390426
- Anat Cell Biol.
- 2017 Mar;50(1):48-59.
- doi: 10.5115/acb.2017.50.1.48
Glycogen synthase kinase (GSK)-3β has been known as a pro-inflammatory molecule in neuroinflammation. The involvement of GSK-3β remains unsolved in acute monophasic rat experimental autoimmune encephalomyelitis (EAE). The aim of... -
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- The Regulation of ERK, GSK3beta and AKT after Acute Ethanol Exposure and Withdrawal in SH-SY5Y Human Neuroblastoma Cell-line
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Roh J, Cui FJ, Kang UG
- KMID: 2341725
- J Korean Neuropsychiatr Assoc.
- 2010 Mar;49(2):241-247.
OBJECTIVES: This study aimed to demonstrate the activities and phosphorylation changes induced by acute ethanol treatment and withdrawal conditions in the intracellular signal transduction molecules [such as extracellular signal-regulated kinase... -
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- Phosphorylation of glycogen synthase kinase-3beta at serine-9 by phospholipase Cgamma1 through protein kinase C in rat 3Y1 fibroblasts
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Shin SY, Yoon SC, Kim YH, Kim YS, Lee YH
- KMID: 1121098
- Exp Mol Med.
- 2002 Dec;34(6):444-450.
Phospholipase Cgamma1 (PLCgamma1) plays an important role in controlling cellular proliferation and differentiation. PLCgamma1 is overexpressed in some tumors, and its overexpression induces solid tumors in nude mice. However,... -
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- Insulin-Like Growth Factor 1 Actions in Developing Brain and the Interaction with Wnt Pathway
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Lee SY
- KMID: 1434737
- Ann Pediatr Endocrinol Metab.
- 2012 Mar;17(1):10-15.
- doi: 10.6065/apem.2012.17.1.10
Insulin like growth factor (IGF)-1 signaling through type 1 IGF receptor (IGF1R) is essential to the normal growth and development of the central nervous system. IGF-1 stimulates proliferation of neural... -
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- Cytoprotective Effect of Epigallocatechin gallate (EGCG) in Oxidative-stressed PC12 Cells Following H2O2 Exposure-Effect of EGCG on Phosphoinositide 3-kinase/Akt and Glycogen Synthase Kinase-3 Pathway
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Koh SH, Kim SH, Kwon H, Song CW, Kim JH, Kim J, Chung B, Kim MH, Gong G, Yu HJ, Jung HK
- KMID: 1635930
- J Korean Neurol Assoc.
- 2003 Aug;21(4):392-400.
BACKGROUND: Neurodegenerative diseases (ND) are associated with oxidative stress, and antioxidants including epigallocatechin gallate (EGCG) have been tried as potential therapeutic regimens of an experimental model of ND. We performed... -
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- GSK3beta Inhibitor Peptide Protects Mice from LPS-induced Endotoxin Shock
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Ko R, Jang HD, Lee SY
- KMID: 2150666
- Immune Netw.
- 2010 Jun;10(3):99-103.
- doi: 10.4110/in.2010.10.3.99
BACKGROUND: Glycogen synthase kinase 3beta (GSK3beta) is a ubiquitous serine/threonine kinase that is regulated by serine phosphorylation at 9. Recent studies have reported the beneficial effects of a number of... -
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- Ferulic acid regulates the AKT/GSK-3beta/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
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Gim SA, Sung JH, Shah FA, Kim MO, Koh PO
- KMID: 1431333
- Lab Anim Res.
- 2013 Jun;29(2):63-69.
- doi: 10.5625/lar.2013.29.2.63
Ferulic acid, a component of the plants Angelica sinensis (Oliv.) Diels and Ligusticum chuanxiong Hort, exerts a neuroprotective effect by regulating various signaling pathways. This study showed that ferulic acid... -
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- Regulatory B Subunits of Protein Phosphatase 2A Are Involved in Site-specific Regulation of Tau Protein Phosphorylation
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Yu UY, Yoo BC, Ahn JH
- KMID: 2285505
- Korean J Physiol Pharmacol.
- 2014 Apr;18(2):155-161.
- doi: 10.4196/kjpp.2014.18.2.155
Overexpression of amyloid precursor protein with the Swedish mutation causes abnormal hyperphosphorylation of the microtubule-associated protein tau. Hyperphosphorylated isoforms of tau are major components of neurofibrillary tangles, which are histopathological... -
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- Melatonin Potentiates the Neuroprotective Properties of Resveratrol Against Beta-Amyloid-Induced Neurodegeneration by Modulating AMP-Activated Protein Kinase Pathways
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Kwon KJ, Kim HJ, Shin CY, Han SH
- KMID: 1462848
- J Clin Neurol.
- 2010 Sep;6(3):127-137.
- doi: 10.3988/jcn.2010.6.3.127
BACKGROUND AND PURPOSE: Recent studies have demonstrated that resveratrol (RSV) reduces the incidence of age-related macular degeneration, Alzheimer's disease (AD), and stroke, while melatonin (MEL) supplementation reduces the progression of... -
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- Cardioprotective signaling cascade of A2 adenosine receptor agonist 5'-N-ethylcarboxaminidoadenosine against myocardial reperfusion injury
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Lee YC, Jang YH, Kim CJ, Kim JM
- KMID: 1782548
- Korean J Anesthesiol.
- 2008 Dec;55(6):716-722.
- doi: 10.4097/kjae.2008.55.6.716
BACKGROUND: This experiments investigated the signaling cascade responsible for anti-infarct effect by an A2 adenosine receptor (AR) agonist 5'-N-Ethylcarboxaminidoadenosine (NECA). METHODS: Langendorff perfused isolated rat hearts were subjected to 30 minutes... -
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- Ischemic Postconditioning Inhibits Mitochondrial Permeability Transition Pore via Opioid Receptor Activation in Intact Rat Heart
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Lee YC, Jang YH, Kim JM, Kim AR, Lee SR, Kim YN, Hong JH
- KMID: 2239820
- Korean J Anesthesiol.
- 2008 Mar;54(3):320-327.
- doi: 10.4097/kjae.2008.54.3.320
BACKGROUND: Ischemic postconditioning (Post-C), brief cycles of myocardial ischemia and reperfusion during the early phase of reperfusion, is considered as a novel adjunct strategy to protect myocardium.However, the exact mechanism... -
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- Amyloid-beta oligomers regulate the properties of human neural stem cells through GSK-3beta signaling
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Lee IS, Jung K, Kim IS, Park KI
- KMID: 2154279
- Exp Mol Med.
- 2013 Nov;45(11):e60.
Alzheimer's disease (AD) is the most common cause of age-related dementia. The neuropathological hallmarks of AD include extracellular deposition of amyloid-beta peptides and neurofibrillary tangles that lead to intracellular hyperphosphorylated... -
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- Increased glucose metabolism and alpha-glucosidase inhibition in Cordyceps militaris water extract-treated HepG2 cells
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Kim DJ, Kang YH, Kim KK, Kim TW, Park JB, Choe M
- KMID: 2407765
- Nutr Res Pract.
- 2017 Jun;11(3):180-189.
- doi: 10.4162/nrp.2017.11.3.180
BACKGROUND/OBJECTIVES: Recent living condition improvements, changes in dietary habits, and reductions in physical activity are contributing to an increase in metabolic syndrome symptoms including diabetes and obesity. Through such societal... -
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