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Diversification of Immunoglobulin Heavy Chain Genes in Bovine IPP Follicles

Jeong YK

  • KMID: 1572997
  • Korean J Immunol.
  • 2000 Jun;22(2):51-55.
No abstract available.
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Immunoglobulin and T-cell receptor gene rearrangement analysis in malignant lymphoid neoplasms

Park CK, Kim CW, Kim IS, Lee JD

Gene rearrangement analysis using Southern-blot hybridization technique is a standard method for evaluating clonal receptor gene rearrangement. Both clonality and lineage can be identified in lymphoid neoplasms by the demonstration...
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Effect of Anti - idiotype Antibody on Anti - DNA Antibody Production by Hybridoma Cells

Youn JK, Kim HI, Kim JD, Park S, Kim YT, Lee MN

  • KMID: 1548376
  • Korean J Immunol.
  • 1997 Dec;19(4):513-524.
Anti-idiotype antibody (anti-id Ab) which recognizes idiotope in the variable region of immunoglobulin (Ig) can regulate Ab production by B cells in vivo and in vitro. Although it has been...
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A Case of Idiopathic Lymphocytoma Cutis

Kim JE, Kim MY, Park YM, Kim HO

The pseudolymphoma of the skin has the architectural and cytological features of a neoplastic proliferation of lymphoid tissue but pursue a benign course. Cutaneous B cell pseudolymphoma (CBPL) shares many...
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Immunoglobulin Gene Repertoire In Rheumatoid Synovium As A Model For Autoimmune Disease

Lee SK, Song JH

  • KMID: 2334737
  • J Korean Rheum Assoc.
  • 1994 Jul;1(2):200-212.
OBJECTIVE: To gain insights into structural characteristics of immunoglobulin kappa chain repertoire expressed in the inflammed synovium of rheumatoid arthritis (RA), we analyzed V kappa transcirpts expressed in the synovium...
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Analysis of Immunoglobulin Gene Rearrangement: Comparison between BIOMED-2 Multiplex PCR and Conventional Nested PCR

Sung JY, Kang SY, Kim SH, Kwon JE, Ko YH

BACKGROUND: Immunoglobulin (Ig) gene rearrangement analysis is a useful additional tool to detect clonality of B-lymphoproliferative disease and the method to detect immunoglobulin gene rearrangement is required the high sensitivity...
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Primary Cutaneous B Cell Lymphoma

Kim KH, Nam JT, Joh GY, Lee YH, Hong SH, Kim CW, Kim KW

We report a case of B-cell lymphoma primarily involving the skin in a 12-year-old boy. The histopathologic findings were compatible with those of small lymphocytic type of non-Hodgkin's lymphoma. A...
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Utility of an immunoglobulin gene rearrangement assay based on multiplex PCR in detecting bone marrow involvement in B-cell non-Hodgkin lymphoma

Park DJ, Cho HC, Kwon JH, Park JY

No abstract available.
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A Case of Cutaneous B-Cell Pseudolymphoma

Chang SE, Kim SH, Choi JH, Sung KJ, Moon KC, Koh JK

  • KMID: 2086347
  • Korean J Dermatol.
  • 2000 Feb;38(2):286-288.
The differentiation between cutaneous pseudolymphomas and primary cutaneous lymphomas is often very difficult, but it is important because each of them has different therapeutic consequences. We report herein a case of cutaneous...
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Clinical Significance of Clonal Rearrangement of the Immunoglobulin Gene in the Bone Marrow of Patients with B-cell Non-Hodgkin Lymphoma

Kim JH, Lee JY, Son JA, Song SA, Oh SH, Shin JH, Kim HR, Jun KR, Lee JN

BACKGROUND: In the early stages of non-Hodgkin lymphoma (NHL), it can be difficult to recognize minimal morphological changes in the bone marrow (BM). In particular, when the quality of the...
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Resurrection of antibody as a therapeutic drug

Chung HK, Chung JH

Currently 18 monoclonal antibodies were approved by FDA for inj ection into humans for therapeutic or diagnostic purpose. And 146 clinical trials are under way to evaluate the efficacy of...
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Production of Human Fab Monoclonal Antibody to Surface Protein, preS1, of Hepatitis B Virus using Antibody Phage Display Library

Kim HS, Choi IH, Kim IJ, Chung JH, Park SK

  • KMID: 1548380
  • Korean J Immunol.
  • 1997 Dec;19(4):549-558.
Human monoclonal antibodies have considerable potential in the prophylaxis and treatment of viral disease. By cloning human Ig gene segments from the B cells of volunteer into pComb3 phagemid vector,...
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Evidence for V(H) Gene Replacement in Human Fetal B Cells

Lee JS, Cho YJ, Lipsky PE

BACKGROUND: In contrast to evidences of Ig H chain receptor editing in transformed cell lines and transgenic mouse models, there has been no direct evidence that this phenomenon occurs in...
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Isolation of Mouse Ig Heavy and Light Chain Genomic DNA Clones, and Construction of Gene Knockout Vector for the Generation of Humanized Xenomouse

Lee HK, Cha SH

BACKGROUND: Monoclonal antibodies (mAb) of rodent origin are produced with ease by hybridoma fusion technique, and have been successfully used as therapeutic reagents for humans after humanization by genetic engineering....
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Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation Manifested as a Soft Tissue Mass: Incidental Discovery on Histological Examination

Ha SY, Choi YL, Kim SJ, Ko YH

  • KMID: 2277507
  • Korean J Pathol.
  • 2011 Aug;45(4):417-422.
We report an extraordinary case of diffuse large B-cell lymphoma arising in a cystic necrotic mass in a 35-year-old man who presented with a soft tissue mass at the site...
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Isolation of Human scFv Antibodies Specific for House Dust Mite Antigens from an Asthma Patient by Using a Phage Display Library

Jung WL, Lee HK, Yong TS, Cha SH

BACKGROUND: In order to characterize human antibodies with specificity for mite allergens at the molecular level, a scFv phage display library was constructed using peripheral blood mononuclear lymphocytes from an...
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