- Gene and Cell Replacement via Neural Stem Cells
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Kim HT, Kim IS, Lim SE, Lee IS, Park KI
- KMID: 1726143
- Yonsei Med J.
- 2004 Jun;45(Suppl):S32-S40.
- doi: 10.3349/ymj.2004.45.Suppl.32
Neural stem cells (NSCs) are operationally defined by their ability to self-renew, to differentiate into cells of all glial and neuronal lineages throughout the neuraxis, and to populate developing or... -
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- Bystander-Mediated Regression of Murine Neuroblastoma via Retroviral Transfer of the HSV-TK Gene
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Cho HS, Lee HR, Kim MK
- KMID: 1785703
- J Korean Med Sci.
- 2004 Feb;19(1):107-112.
- doi: 10.3346/jkms.2004.19.1.107
Selective introduction of genes conferring chemosensitivity into proliferating tumor cells may be used to treat cancer. We investigated the bystander effect of retrovirusmediated gene transfer of herpes simplex virus thymidine... -
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- Improvement of DNA vaccination by adjuvants and sophisticated delivery devices: vaccine-platforms for the battle against infectious diseases
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Grunwald T, Ulbert S
- KMID: 2049102
- Clin Exp Vaccine Res.
- 2015 Jan;4(1):1-10.
- doi: 10.7774/cevr.2015.4.1.1
Advantages of DNA vaccination against infectious diseases over more classical immunization methods include the possibilities for rapid manufacture, fast adaptation to newly emerging pathogens and high stability at ambient temperatures.... -
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- Optimizing in vivo gene transfer into mouse corpus cavernosum by use of surface electroporation
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Song KM, Choi MJ, Kwon MH, Ghatak K, Park SH, Ryu DS, Ryu JK, Suh JK
- KMID: 2133287
- Korean J Urol.
- 2015 Mar;56(3):197-204.
- doi: 10.4111/kju.2015.56.3.197
PURPOSE: Electroporation is known to enhance the efficiency of gene transfer through a transient increase in cell membrane permeability. The aim of this study was to determine the optimal conditions... -
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- Enhanced induction of Bax gene expression in H460 and H1299 cells with the combined treatment of cisplatin and adenovirus mediated wt-p53 gene transfer
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Choi JH, Ahn KS, Kim JG, Hong YS
- KMID: 927130
- Exp Mol Med.
- 2000 Mar;32(1):23-28.
Cytotoxic effect of either cisplatin or p53 gene transfection of lung cancer cells may be different depending on the p53 status of cells. We investigated cytotoxic effects on the combined... -
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- Transgenesis for pig models
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Yum SY, Yoon KY, Lee CI, Lee BC, Jang G
- KMID: 2413124
- J Vet Sci.
- 2016 Sep;17(3):261-268.
- doi: 10.4142/jvs.2016.17.3.261
Animal models, particularly pigs, have come to play an important role in translational biomedical research. There have been many pig models with genetically modifications via somatic cell nuclear transfer (SCNT).... -
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- Retroviral-mediated IL-2 gene transfer into murine neuroblastoma
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Cho HS, Song JY, Park CY, Lyu CJ, Kim BS, Kim KY
- KMID: 1060275
- Yonsei Med J.
- 2000 Feb;41(1):76-81.
- doi: 10.3349/ymj.2000.41.1.76
We used retroviral-mediated gene transfer of the human interleukin (IL)-2 gene into murine neuroblastoma cells to investigate whether locally-secreted IL-2 is able to influence the generation of anti-tumor immune responses.... -
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- Inhibition of rac1 Reduces PDGF-induced Reactive Oxygen Species and Proliferation in Vascular Smooth Muscle Cells
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Kong G, Lee S, Kim KS
- KMID: 648350
- J Korean Med Sci.
- 2001 Dec;16(6):712-718.
- doi: 10.3346/jkms.2001.16.6.712
In vascular smooth muscle cells, reactive oxygen species (ROS) were known to mediate platelet-derived growth factor (PDGF)-induced cell proliferation and NADH/NADPH oxidase is the major source of ROS. NADH/NADPH oxidase... -
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- Hepatocyte Growth Factor and Kidney Disease
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Park JS, Kim GH
- KMID: 2252674
- Korean J Nephrol.
- 2011 Jul;30(4):359-367.
Hepatocyte growth factor (HGF), also known as scatter factor, was identified during the experimental attempts to explore a phantom factor acting as a trigger for liver regeneration after partial hepatecotmy.... -
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- Recombinant adeno-associated virus mediated gene transfer in a mouse model for homocystinuria
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Park ES, Oh HJ, Kruger WD, Jung SC, Lee JS
- KMID: 1115943
- Exp Mol Med.
- 2006 Dec;38(6):652-661.
Homocystinuria is a metabolic disorder caused by a deficiency of cystathionine b-synthase (CBS). The major clinical symptoms of this disease are mental retardation, lens dislocation, vascular disease with life-threatening thromboembolisms,... -
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- Gene Delivery to the Rat Liver Using Cationic Lipid Emulsion/DNA Complex: Comparison between Intra-arterial, Intraportal and Intravenous Administration
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Choi BY, Chung JW, Park JH, Kim KH, Kim YI, Koh YH, Kwon JW, Lee KH, Choi HJ, Kim TW, Kim YJ, Chung H, Kwon IC, Jeong SY
- KMID: 754062
- Korean J Radiol.
- 2002 Sep;3(3):194-198.
- doi: 10.3348/kjr.2002.3.3.194
OBJECTIVE: To compare the efficiency of intra-arterial, intraportal, and intravenous administration of cationic lipid emulsion/DNA complex, as used for gene transfer to rat liver. MATERIALS AND METHODS: DNA-carrier complex for the... -
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- Local Immunotherapy to Treat Metastatic Liver Cancer by Biodegradable Microspheres Containing Interleukin - 2
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Suh KW, Hanes JS
- KMID: 2175136
- J Korean Cancer Assoc.
- 1999 Dec;31(6):1246-1252.
PURPOSE: We tried to elucidate antitumor effect of interleukin-2 containing miscrospheres (IL-2 MS) against intrahepatic challenge of parental cancer cells, which is clinically relevant tumor model. MATERIALS AND METHODS: Using a... -
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- Improved expression by cytomegalovirus promoter/enhancer and behavior of vascular endothelial growth factor gene after myocardial injection of naked DNA
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Jeong JO, Byun JH, Jeon ES, Gwon HC, Lim YS, Park JW, Yeo SJ, Lee YJ, Kim SY, Kim DK
- KMID: 931878
- Exp Mol Med.
- 2002 Sep;34(4):278-284.
Direct injection of the vascular endothelial growth factor (VEGF) gene plasmid DNA into the myocardium was shown to induce development of new blood vessels to increase the circulation in... -
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- Blood Pressure Regulation by Vasoactive Peptide Genes: Transgenic And Knockout Animal Models
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Ahn D
- KMID: 2134792
- Electrolyte Blood Press.
- 2005 Mar;3(1):14-23.
Hypertension is a polygenic and multifactorial disease and is intimately related to salt homeostasis. Four important vasoactive peptide systems participate in regulating blood pressure and salt homeostasis. Their interplay is... -
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- Gene transfer using liposome-complexed adenovirus seems to overcome limitations due to coxsackievirus and adenovirus receptor-deficiency of cancer cells, both in vitro and in vivo
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Han SY, Lee YJ, Jung HI, Lee SW, Lim SJ, Hong SH, Jeong JS
- KMID: 1094122
- Exp Mol Med.
- 2008 Aug;40(4):427-434.
- doi: 10.3858/emm.2008.40.4.427
Use of adenoviruses as vehicle for gene therapy requires that target cells express appropriate receptors such as coxsakievirus and adenovirus receptor (CAR). We show here that CAR-deficiency in cancer cells,... -
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- p53 gene transfer does not enhance E2F-1-mediated apoptosis in human colon cancer cells
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Draus JM, Elliott MJ, Atienza C, Stilwell A, Wong SL, Dong Y, Yang H, McMasters
- KMID: 1457532
- Exp Mol Med.
- 2001 Dec;33(4):209-219.
E2F-1 and p53 are sequence specific transcription factors that are intimately involved in the regulation of the cell cycle. In addition to their role in cell cycle control, both E2F-1... -
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- Isolation of Mouse Ig Heavy and Light Chain Genomic DNA Clones, and Construction of Gene Knockout Vector for the Generation of Humanized Xenomouse
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Lee HK, Cha SH
- KMID: 1974523
- Immune Netw.
- 2002 Dec;2(4):233-241.
- doi: 10.4110/in.2002.2.4.233
BACKGROUND: Monoclonal antibodies (mAb) of rodent origin are produced with ease by hybridoma fusion technique, and have been successfully used as therapeutic reagents for humans after humanization by genetic engineering.... -
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- Development of an efficient endothelial cell specific vector using promoter and 5' untranslated sequences from the human preproendothelin-1 gene
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Cho JY, Lim WC, Jang S, Lee YJ
- KMID: 1109315
- Exp Mol Med.
- 2003 Aug;35(4):269-274.
We report here, that a vector constructed based on ppET-1 gene promoter and 5' untranslated region induced a high level of gene expression in endothelial cells and the specificity is... -
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- Prolonged hypotensive effect of human tissue kallikrein gene delivery and recombinant enzyme administration in spontaneous hypertension rats
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Sun H, Zhang L, Wang A, Xue Z
- KMID: 755661
- Exp Mol Med.
- 2004 Feb;36(1):23-27.
To evaluate the feasibility of treating hypertension by human tissue kallikrein gene (KLK1) delivery and by enzyme (rK1) administration, two recombinant vectors expressing KLK1 cDNA were constructed for gene delivery... -
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- The Validation of RT-PCR Assay for Detection of Replication-competent Lentivirus (RCL) in Vector Preparations Using HIV Vector Based Gene Delivery System
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Yoo ES
- KMID: 2140620
- Korean J Pediatr Hematol Oncol.
- 2002 Apr;9(1):108-116.
PURPOSE: Unlike murine oncoretroviruses which can infect only dividing cells, lentiviral vector based on HIV have been shown to efficiently transfer genetic materials into a various cells which makes... -
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