- Exosomes and Microvesicles as Biomarkers in Metabolic Diseases
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Lee SK
- KMID: 2271123
- Korean J Obes.
- 2014 Sep;23(3):150-155.
- doi: 10.7570/kjo.2014.23.3.150
Currently used biomarkers in metabolic diseases are neither sufficient for monitoring the stage of disease development nor for monitoring differences among patients with different underlying pathogenetic pathways and pathogenesis. Exosomes... -
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- Quantitative Analysis of Exosomes From Murine Lung Cancer Cells by Flow Cytometry
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Rim KT, Kim SJ
- KMID: 2367578
- J Cancer Prev.
- 2016 Sep;21(3):194-200.
- doi: 10.15430/JCP.2016.21.3.194
In vivo studies regarding biochemical, molecular biological, and histopathological changes in cancer tissues have been widely performed by the administration of carcinogens in rodents. In these established methods, dissection of... -
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- Exosomes as the source of biomarkers of metabolic diseases
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Lee MJ, Park DH, Kang JH
- KMID: 2366786
- Ann Pediatr Endocrinol Metab.
- 2016 Sep;21(3):119-125.
- doi: 10.6065/apem.2016.21.3.119
Exosomes are extracellular vesicles that contain molecules that regulate the metabolic functions of adjacent or remote cells. Recent in vitro, in vivo and clinical studies support the hypothesis that exosomes... -
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- The potential theragnostic (diagnostic+therapeutic) application of exosomes in diverse biomedical fields
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Kim YS, Ahn JS, Kim S, Kim HJ, Kim SH, Kang JS
- KMID: 2410101
- Korean J Physiol Pharmacol.
- 2018 Mar;22(2):113-125.
- doi: 10.4196/kjpp.2018.22.2.113
Exosomes are membranous vesicles of 30-150 nm in diameter that are derived from the exocytosis of the intraluminal vesicles of many cell types including immune cells, stem cells, cardiovascular cells... -
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- Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases
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Lou G, Chen Z, Zheng M, Liu Y
- KMID: 2386966
- Exp Mol Med.
- 2017 Jun;49(6):e346.
- doi: 10.1038/emm.2017.63
The administration of mesenchymal stem cells (MSCs) as a therapy for liver disease holds great promise. MSCs can differentiate into hepatocytes, reduce liver inflammation, promote hepatic regeneration and secrete protective... -
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- Extracellular Vesicles as a Source of Urological Biomarkers: Lessons Learned From Advances and Challenges in Clinical Applications to Major Diseases
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Choi JY, Kim S, Kwak HB, Park DH, Park JH, Ryu JS, Park CS, Kang JH
- KMID: 2387168
- Int Neurourol J.
- 2017 Jun;21(2):83-96.
- doi: 10.5213/inj.1734961.458
Extracellular vesicles (EVs) not only eliminate unwanted molecular components, but also carry molecular cargo essential for specific intercellular communication mechanisms. As the molecular characteristics and biogenetical mechanisms of heterogeneous EVs... -
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- Exosomes as Therapeutic Vehicles for Cancer
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Lim W, Kim HS
- KMID: 2449233
- Tissue Eng Regen Med.
- 2019 Jun;16(3):213-223.
- doi: 10.1007/s13770-019-00190-2
BACKGROUND: Exosomes are membrane-enclosed extracellular vesicles implicated in cell-cell communication. Exosomes contain proteins, mRNAs, non-coding RNAs (miRNAs and lncRNAs) and lipids that are derived from producing cells. These nano-sized vesicles... -
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- Exosomes as a Communication Tool Between the Lymphatic System and Bladder Cancer
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Park RJ, Hong YJ, Wu Y, Kim PM, Hong YK
- KMID: 2422511
- Int Neurourol J.
- 2018 Sep;22(3):220-224.
- doi: 10.5213/inj.1836186.093
No abstract available. -
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- Circulating Plasma and Exosomal microRNAs as Indicators of Drug-Induced Organ Injury in Rodent Models
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Cho YE, Kim SH, Lee BH, Baek MC
- KMID: 2386902
- Biomol Ther.
- 2017 Jul;25(4):367-373.
- doi: 10.4062/biomolther.2016.174
This study was performed to evaluate whether microRNAs (miRNAs) in circulating exosomes may serve as biomarkers of drug-induced liver, kidney, or muscle-injury. Quantitative PCR analyses were performed to measure the... -
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- Proteomic Analysis on Exosomes Derived from Patients’ Sera Infected with Echinococcus granulosus
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Wang W, Zhou X, Cui F, Shi C, Wang Y, Men Y, Zhao W, Zhao J
- KMID: 2463736
- Korean J Parasitol.
- 2019 Oct;57(5):489-497.
- doi: 10.3347/kjp.2019.57.5.489
Cystic echinococcosis (CE), a zoonotic disease caused by Echinococcus granulosus at the larval stage, predominantly develops in the liver and lungs of intermediate hosts and eventually results in organ malfunction... -
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- Exosomes Secreted by Toxoplasma gondii-Infected L6 Cells: Their Effects on Host Cell Proliferation and Cell Cycle Changes
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Kim MJ, Jung BK, Cho J, Song H, Pyo KH, Lee JM, Kim MK, Chai JY
- KMID: 2164011
- Korean J Parasitol.
- 2016 Apr;54(2):147-154.
- doi: 10.3347/kjp.2016.54.2.147
Toxoplasma gondii infection induces alteration of the host cell cycle and cell proliferation. These changes are not only seen in directly invaded host cells but also in neighboring cells. We... -
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- Adipose stem cell-derived nanovesicles inhibit emphysema primarily via an FGF2-dependent pathway
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Kim YS, Kim JY, Cho R, Shin DM, Lee SW, Oh YM
- KMID: 2367530
- Exp Mol Med.
- 2017 Jan;49(1):e284.
- doi: 10.1038/emm.2016.127
Cell therapy using stem cells has produced therapeutic benefits in animal models of COPD. Secretory mediators are proposed as one mechanism for stem cell effects because very few stem cells... -
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- Exosome-derived microRNAs in cancer metabolism: possible implications in cancer diagnostics and therapy
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Tomasetti , Lee W, Santarelli L, Neuzil J
- KMID: 2367531
- Exp Mol Med.
- 2017 Jan;49(1):e285.
- doi: 10.1038/emm.2016.153
Malignant progression is greatly affected by dynamic cross-talk between stromal and cancer cells. Exosomes are secreted nanovesicles that have key roles in cell–cell communication by transferring nucleic acids and proteins... -
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- Brain Theranostics and Radiotheranostics: Exosomes and Graphenes In Vivo as Novel Brain Theranostics
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Suh M, Lee DS
- KMID: 2431978
- Nucl Med Mol Imaging.
- 2018 Dec;52(6):407-419.
- doi: 10.1007/s13139-018-0550-9
Brain disease is one of the greatest threats to public health. Brain theranostics is recently taking shape, indicating the treatments of stroke, inflammatory brain disorders, psychiatric diseases, neurodevelopmental disease, and... -
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- Three-Dimensional Spheroid Culture Increases Exosome Secretion from Mesenchymal Stem Cells
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Kim M, Yun HW, Park DY, Choi BH, Min BH
- KMID: 2418099
- Tissue Eng Regen Med.
- 2018 Aug;15(4):427-436.
- doi: 10.1007/s13770-018-0139-5
BACKGROUND: Mass production of exosomes is a prerequisite for their commercial utilization. This study investigated whether three-dimensional (3D) spheroid culture of mesenchymal stem cells (MSCs) could improve the production efficiency... -
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- Introduction of the CIITA gene into tumor cells produces exosomes with enhanced anti-tumor effects
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Lee YS, Kim SH, Cho JA, Kim CW
- KMID: 1009967
- Exp Mol Med.
- 2011 May;43(5):281-290.
- doi: 10.3858/emm.2011.43.5.029
Exosomes are small membrane vesicles secreted from various types of cells. Tumor-derived exosomes contain MHC class I molecules and tumor-specific antigens, receiving attention as a potential cancer vaccine. For induction... -
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- Immunosuppressive Effect of Exosomes from Mesenchymal Stromal Cells in Defined Medium on Experimental Colitis
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Ma ZJ, Wang YH, Li ZG, Wang Y, Li BY, Kang HY, Wu XY
- KMID: 2465884
- Int J Stem Cells.
- 2019 Nov;12(3):440-448.
- doi: 10.15283/ijsc18139
BACKGROUND AND OBJECTIVES: The exosomes released by mesenchymal stromal cells (MSCs) in classical FBS-containing media have been demonstrated as an alternative, cell-free therapy in various diseases including inflammatory bowel disease... -
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- Initiation of human parturition: signaling from senescent fetal tissues via extracellular vesicle mediated paracrine mechanism
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Menon R
- KMID: 2451649
- Obstet Gynecol Sci.
- 2019 Jul;62(4):199-211.
- doi: 10.5468/ogs.2019.62.4.199
A better understanding of the underlying mechanisms by which signals from the fetus initiate human parturition is required. Our recent findings support the core hypothesis that oxidative stress (OS) and... -
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- Recent Advances in Biosensors for Nucleic Acid and Exosome Detection
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Fu Z, Lu YC, Lai JJ
- KMID: 2447210
- Chonnam Med J.
- 2019 May;55(2):86-98.
- doi: 10.4068/cmj.2019.55.2.86
Biosensors are analytical devices for biomolecule detection that compromise three essential components: recognition moiety, transducer, and signal processor. The sensor converts biomolecule recognition to detectable signals, which has been applied... -
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- Extracellular Vesicles and the Promise of Continuous Liquid Biopsies
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Armstrong , Wildman DE
- KMID: 2403251
- J Pathol Transl Med.
- 2018 Jan;52(1):1-8.
- doi: 10.4132/jptm.2017.05.21
The rapid and accurate diagnosis of patients with minimally invasive procedures was once only found in science fiction. However, the discovery of extracellular vesicles (EVs) and their near ubiquity in... -
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