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Endoplasmic Reticulum Stress and Diabetes

Kim MK, Park KG

No abstract available.
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Endoplasmic Reticulum (ER) Stress and Vascular Complication

Kim HK, Lee IK

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New Insights into the Role of Endoplasmic Reticulum Stress in Breast Cancer Metastasis

Han CC, Wan FS

Cellular stress severely disrupts endoplasmic reticulum (ER) function, leading to the abnormal accumulation of unfolded or misfolded proteins in the ER and subsequent development of endoplasmic reticulum stress (ERS). To...
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Nuclear Receptors Resolve Endoplasmic Reticulum Stress to Improve Hepatic Insulin Resistance

Lee JM

Chronic endoplasmic reticulum (ER) stress culminating in proteotoxicity contributes to the development of insulin resistance and progression to type 2 diabetes mellitus. Pharmacologic interventions targeting several different nuclear receptors have...
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Endoplasmic Reticulum Stress Responses and Apoptosis

Song CH

The endoplasmic reticulum (ER) plays a crucial role in various cellular activities and cell survival. Almost all of the resident proteins usually enter the ER, and are modified with N-linked...
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Endoplasmic Reticulum Stress and the Related Signaling Networks in Severe Asthma

Kim SR, Lee YC

The endoplasmic reticulum (ER) is a specialized organelle that plays a central role in biosynthesis, correct protein folding, and posttranslational modifications of secretory and membrane proteins. Loss of homeostasis in...
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Role of Endoplasmic Reticulum Stress in Rheumatoid Arthritis Pathogenesis

Park YJ, Yoo SA, Kim WU

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by abnormal proliferation of synoviocytes, leukocyte infiltration, and angiogenesis. The endoplasmic reticulum (ER) is the site of biosynthesis for all secreted...
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Endoplasmic reticulum stress in periimplantation embryos

Michalak M, Gye MC

Stress coping mechanisms are critical to minimize or overcome damage caused by ever changing environmental conditions. They are designed to promote cell survival. The unfolded protein response (UPR) pathway is...
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High-concentration Epigallocatechin Gallate Treatment Causes Endoplasmic Reticulum Stress-mediated Cell Death in HepG2 Cells

Ahn JI, Jeong KJ, Ko MJ, Shin HJ, Chung HJ, Jeong HS

  • KMID: 2053228
  • Genomics Inform.
  • 2009 Jun;7(2):97-106.
Epigallocatechin gallate (EGCG), a well-known antioxidant molecule, has been reported to cause hepatotoxicity when used in excess. However, the mechanism underlying EGCG-induced hepatotoxicity is still unclear. To better understand the...
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A Study on the Cytotoxicity of Bupivacaine in cultured Rat Myocardial Cells

Chae JH, Kim TY

In an attempt to evaluate the cardiotoxicity of bupivacaine, beating rate, tetrazolium MTT and lactate dehydrogenase activity were investigated in the medium containing bupivacaine for 24 hours after neonatal rat...
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Histochemical and Electron Microscopic Studies on the Canal Epithelium of the body Segment of the Rabbit Epididymis

Oh HS

  • KMID: 2059979
  • Korean J Urol.
  • 1974 Dec;15(4):241-249.
Histochemical and electron microscopic studies were made on the canal epithelium of the body segment of the rabbit epididymis and following results were obtained. 1) Acid phosphatase activity was marked...
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Electron Microscopic Observation of Treponema pallidum in Syphilitic Chancres and Syphilids

Lee MG, Chung I, Leen ES, Lee JB

Electron mlactimpic studies were performed on three primary and two early secondary syphilitic lesions from three patients. AZ of these patients had both secondary syphilitic lesions and chancres. There was no...
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Vitamin C Induces Apoptosis in Human Colon Cancer Cell Line, HCT-8 Via the Modulation of Calcium Influx in Endoplasmic Reticulum and the Dissociation of Bad from 14-3-3beta

Kim JE, Kang JS, Lee WJ

It has been reported that vitamin C plays an effective role in the treatment and prevention of cancer, but its specific mechanisms are still largely unknown. The incidence of colon...
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Fine Structure of the Neurons and Synapses in the Caudate Nucleus of the Guinea Pig

Lee HL

The caudate nucleus of the guinea pig was examined at the ultrastructural level. At least four types of neurons and seven types of synapses are distinguished. The large polygonal neurons...
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Emodin exerts protective effect against palmitic acid-induced endoplasmic reticulum stress in HepG2 cells

Thomas SS, Park S, Cha YS, Kim KA

PURPOSE: Protein overloading in the endoplasmic reticulum (ER) leads to endoplasmic reticulum stress, which exacerbates various disease conditions. Emodin, an anthraquinone compound, is known to have several health benefits. The...
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Blockade of Autophagy Aggravates Endoplasmic Reticulum Stress and Improves Paclitaxel Cytotoxicity in Human Cervical Cancer Cells

Xu L, Liu JH, Zhang J, Zhang N, Wang ZH

PURPOSE: Autophagy is one of the ways to degrade unfolded proteins after endoplasmic reticulum (ER) stress. The purpose of this study is to determine whether a blockade of autophagy leads...
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Characterization of Endoplasmic Reticulum Stress and Apoptosis in Macrophages Infected with Mycobacterium tuberculosis Isolates from Korea Patients

Lee JH, Lim YJ, Choi JA, Han JY, Cho SH, Oh SM, Song CH

Apoptosis is an important host defense mechanism against mycobacterial infection. Recent reports suggest that links between apoptosis and endoplasmic reticulum (ER) stress are critical for the regulation of mycobacterial survival;...
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The signal sequence of type II porcine reproductive and respiratory syndrome virus glycoprotein 3 is sufficient for endoplasmic reticulum retention

Kim DG, Song CS, Choi IS, Park SY, Lee JB, Lee SS

The glycoprotein 3 (GP3) of type II porcine reproductive and respiratory syndrome virus has the characteristic domains of a membrane protein. However, this protein has been reported to be retained...
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Microscopic Findings of Cultured Human Melanocytes from a Vitiligo Subject

Cho YH, Lee MH

  • KMID: 2303476
  • Korean J Dermatol.
  • 1997 Jun;35(3):571-574.
Vitiligo is an acquired systemic disease of the skin characterized by circumscribed patches of complete pigment loss due to destruction of melanocytes. A 28-year old male patient presented with...
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Role of autophagy in diabetes and endoplasmic reticulum stress of pancreatic beta-cells

Quan W, Lim YM, Lee MS

Type 2 diabetes mellitus is characterized by insulin resistance and failure of pancreatic beta-cells producing insulin. Autophagy plays a crucial role in cellular homeostasis through degradation and recycling of organelles...
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