- Inhibitor of DNA-binding 4 contributes to the maintenance and expansion of cancer stem cells in 4T1 mouse mammary cancer cell line
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Park SJ, Kim RJ, Nam JS
- KMID: 1444966
- Lab Anim Res.
- 2011 Dec;27(4):333-338.
- doi: 10.5625/lar.2011.27.4.333
The cancer stem cell (CSC) hypothesis proposes that CSCs are the root of cancer. CSC-targeted therapies may prevent cancer relapse and provide more effective treatment. The expression of aldehyde dehydrogenase... -
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- Isolation of a Partial Human cDNA Encoding a Factor Binding to the Perfect Palindrome of Enhancer A of HLA Class I Promoter, Homologous to NF-kB2
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Park JH, Lee TJ, Kim SJ
- KMID: 1551643
- J Korean Soc Microbiol.
- 1998 Jun;33(3):295-306.
Genes encoding sequence-specific DNA binding proteins have been isolated by screening cDNA libraries constructed in rgt11 expression vector with recognition site DNAs. We isolated a rgt11 recombinant human cDNA clone,... -
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- DNAse I hypersensitive sites of lung specific transcription factor gene
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Lee YC
- KMID: 2160239
- Tuberc Respir Dis.
- 2000 Jun;48(6):879-886.
- doi: 10.4046/trd.2000.48.6.879
BACKGROUND: Thyroid Transcription Factor-1(TTF-1) acts as a tissue specific transcription factor in the regulation of lung specific gene expression and as morphogenic protein during lung organogenesis. Currently, there is very... -
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- A radioimmunoassay method for detection of DNA based on chemical immobilization of anti-DNA antibody
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Yoo SK, Yoon MO, Park UJ, Han HS, Kim JH, Hwang HJ
- KMID: 755039
- Exp Mol Med.
- 1999 Sep;31(3):122-125.
High selectivity provided by biomolecules such as antibodies and enzymes has been exploited during the last two decades for development of biosensors. Of particular importance are efficient immobilization methods for biomolecules in order... -
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- The Pathogenetic Role of TAR DNA Binding Protein (TDP-43) in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
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Kang SY
- KMID: 2065761
- J Korean Neurol Assoc.
- 2011 Feb;29(1):1-8.
The recent identification of the transactive response DNA binding protein with a molecular weight of 43 kDa (TDP-43) as the major pathological protein, in both amyotrophic lateral sclerosis (ALS) and... -
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- Dissecting the molecular mechanism of nuclear receptor action: transcription coactivators and corepressors
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Lee JW, Cheong JH, Lee YC, Na SY, lee SK
- KMID: 1109302
- Exp Mol Med.
- 2000 Jun;32(2):53-60.
No abstract available. -
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- Yin and Yang: the Gastric X/A-like Cell as Possible Dual Regulator of Food Intake
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Stengel A, Tache Y
- KMID: 2325878
- J Neurogastroenterol Motil.
- 2012 Apr;18(2):138-149.
Ingestion of food affects secretion of hormones from enteroendocrine cells located in the gastrointestinal mucosa. These hormones are involved in the regulation of various gastrointestinal functions including the control of... -
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- Toward understanding the role of the neuron-specific BAF chromatin remodeling complex in memory formation
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Choi KY, Yoo M, Han JH
- KMID: 2070274
- Exp Mol Med.
- 2015 Apr;47(4):e155.
- doi: 10.1038/emm.2014.129
The long-term storage of memory requires the finely tuned coordination of intracellular signaling with the transcriptional, translational and epigenetic regulations of gene expression. Among the epigenetic mechanisms, however, we know... -
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- Different protein-binding patterns in the P3 promoter region of the human insulin-like growth factor II gene in the human liver cirrhosis and hepatocellular carcinoma tissues
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Seo JH, Kim KW, Park BC
- KMID: 1064965
- J Korean Med Sci.
- 1998 Apr;13(2):171-178.
- doi: 10.3346/jkms.1998.13.2.171
The P3 promoter of the human insulin-like growth factor II (IGF-II) is the major IGF-II promoter in fetal liver (FL) and hepatocellular carcinoma (HCC). However, little information is available... -
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- Possible Role of Single Stranded DNA Binding Protein 3 on Skin Hydration by Regulating Epidermal Differentiation
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Choi MR, Shin JM, Shin YA, Chang YH, Chang MY, Lim CA, Sohn KC, Seo YJ, Kim CD, Lee JH, Lee Y
- KMID: 2457520
- Ann Dermatol.
- 2018 Aug;30(4):432-440.
- doi: 10.5021/ad.2018.30.4.432
BACKGROUND: Skin hydration is a common problem both in elderly and young people as dry skin may cause irritation, dermatological disorders, and wrinkles. While both genetic and environmental factors seem... -
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- Association of Polymorphic Regulatory Region of TIGR Gene with Glaucoma
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Koo HJ, Son S, Kee C
- KMID: 2205978
- J Korean Ophthalmol Soc.
- 2001 Mar;42(3):519-526.
PURPOSE: To identify the polymorphism in the regulatory region of trabecular meshwork inducible glucocorticoid response(TIGR) gene and evaluate the association of it with glaucoma. METHODS: 5'regulatory region of TIGR gene... -
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- Profiling of Differentially Expressed Genes in Human Polymorphonuclear Leukocyte on Human Amniotic Membrane
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Kim HK, Han GH, Choi TH
- KMID: 2337120
- J Korean Ophthalmol Soc.
- 2003 Nov;44(11):2615-2626.
PURPOSE: To identify genes that showed altered expression between human polymorphonuclear (PMN) cell cultured on plastic and on amniotic membrane by the technique of differential hybridization of two Altas(TM) Human... -
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- Non-Homologous End Joining Repair Mechanism-Mediated Deletion of CHD7 Gene in a Patient with Typical CHARGE Syndrome
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Lee SJ, Chae JH, Lee JA, Cho SI, Seo SH, Park H, Seong MW, Park SS
- KMID: 2363163
- Ann Lab Med.
- 2015 Jan;35(1):141-145.
- doi: 10.3343/alm.2015.35.1.141
CHARGE syndrome MIM #214800 is an autosomal dominant syndrome involving multiple congenital malformations. Clinical symptoms include coloboma, heart defects, choanal atresia, retardation of growth or development, genital hypoplasia, and ear... -
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- Decreased expression of DNA repair proteins Ku70 and Mre11 is associated with aging and may contribute to the cellular senescence
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Ju YJ, Lee KH, Park JE, Yi YS, Yun MY, Ham YH, Kim TJ, Choi HM, Han GJ, Lee JH, Lee J, Han JS, Lee KM, Park GH
- KMID: 1115947
- Exp Mol Med.
- 2006 Dec;38(6):686-693.
The gradual loss of telomeric DNA can contribute to replicative senescence and thus, having longer telomeric DNA is generally considered to provide a longer lifespan. Maintenance and stabilization of telomeric... -
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- DNA mismatch repair-related protein loss as a prognostic factor in endometrial cancers
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Kato M, Takano M, Miyamoto M, Sasaki N, Goto T, Tsuda H, Furuya K
- KMID: 2158801
- J Gynecol Oncol.
- 2015 Jan;26(1):40-45.
- doi: 10.3802/jgo.2015.26.1.40
OBJECTIVE: Recent investigations have revealed DNA mismatch repair (MMR) gene mutations are closely related with carcinogenesis of endometrial cancer; however the impact of MMR protein expression on prognosis is not... -
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- Suppression of NF-kappaB activation in normal T cells by supernatant fluid from human renal cell carcinomas
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Kim HJ, Park JK, Kim YG
- KMID: 646309
- J Korean Med Sci.
- 1999 Jun;14(3):299-303.
- doi: 10.3346/jkms.1999.14.3.299
T lymphocytes from patients with renal cell carcinoma (RCC) show reduced immune function and impaired activation of the transcription factor, NF-kappaB. We determined the mechanism of NF-kappaB suppression in T... -
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- Early cerebellar granule cell migration in the mouse embryonic development
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Chung SH, Kim CT, Jung YH, Lee NS, Jeong YG
- KMID: 2168901
- Anat Cell Biol.
- 2010 Mar;43(1):86-95.
- doi: 10.5115/acb.2010.43.1.86
Pax6, a paired homeobox DNA binding protein, has been found to be expressed in the cerebellum in both granule cells and their precursors in the external granular layer (EGL). In... -
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- Hypoxia activates signal transducers and activators of transcription 5 (STAT5) and increases its binding activity to the GAS element in mammary epithelial cells
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Joung YH, Park JH, Park T, Lee CS, Kim OH, Ye SK, Yang UM, Lee KJ, Yang YM
- KMID: 1093606
- Exp Mol Med.
- 2003 Oct;35(5):350-357.
STATs (signal transducers and activators of transcription) are proteins with dual functions: signal transducers in the cytoplasm and transcriptional activators in the nucleus. STAT proteins act as transcription factors activated... -
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- Langerhans cell protein 1 (LCP1) binds to PNUTS in the nucleus: implications for this complex in transcriptional regulation
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Lee SJ, Lee JK, Maeng YS, Kim YM, Kwon YG
- KMID: 1123466
- Exp Mol Med.
- 2009 Mar;41(3):189-200.
- doi: 10.3858/emm.2009.41.3.022
Protein phosphatase-1 (PP1) nuclear targeting subunit (PNUTS), also called PP1R10, p99, or CAT 53 was originally isolated as a mammalian nuclear PP1-binding protein. In this study, we performed yeast two-hybrid... -
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- Letter to the Editor: Presence of Evolutionary Pressures or Genotyping Error
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Saadat M
- KMID: 1793010
- J Korean Med Sci.
- 2012 Mar;27(3):335-335.
- doi: 10.3346/jkms.2012.27.3.335
No abstract available. -
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